Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9245
Gene name	Glucosaminyl (N-acetyl) transferase 3, mucin type
Gene symbol	GCNT3
Synonyms (NCBI Gene)	C2/4GnTC24GNTC2GNT2C2GNTMGNTM
Chromosome	15
Chromosome location	15q22.2
Summary	This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017911	hsa-miR-335-5p	Microarray	18185580
MIRT2234072	hsa-miR-302a	CLIP-seq
MIRT2234073	hsa-miR-302b	CLIP-seq
MIRT2234074	hsa-miR-302c	CLIP-seq
MIRT2234075	hsa-miR-302d	CLIP-seq
MIRT2234076	hsa-miR-372	CLIP-seq
MIRT2234077	hsa-miR-373	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0003829	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IEA
GO:0003829	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005975	Process	Carbohydrate metabolic process	NAS	9988682
GO:0006486	Process	Protein glycosylation	IEA
GO:0006493	Process	Protein O-linked glycosylation	TAS	9988682
GO:0008109	Function	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	IEA
GO:0008109	Function	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	TAS	9988682
GO:0008194	Function	UDP-glycosyltransferase activity	IEA
GO:0008375	Function	Acetylglucosaminyltransferase activity	IBA
GO:0009101	Process	Glycoprotein biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9988682
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0047225	Function	Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IEA
GO:0048729	Process	Tissue morphogenesis	IEA
GO:0050892	Process	Intestinal absorption	IEA
GO:0060993	Process	Kidney morphogenesis	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
606836	4205	ENSG00000140297

O95395

Protein name

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)

Protein function

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into br

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02485	Branch	133 → 402	Core-2/I-Branching enzyme	Family

Tissue specificity

TISSUE SPECIFICITY: Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269|PubMed:17303715, ECO:0000269|PubMed:9915862}.

Sequence

MVQWKRLCQLHYLWALGCYMLLATVALKLSFRLKCDSDHLGLESRESQSQYCRNILYNFL
KLPAKRSINCSGVTRGDQEAVLQAILNNLEVKKKREPFTDTHYLSLTRDCEHFKAERKFI
QFPLSKEEVEFPIAYSMVIHEKIENFERLLRAVYAPQNIYCVHVDEKSPETFKEAVKAII
SCFPNVFIASKLVRVVYASWSRVQADLNCMEDLLQSSVPWKYFLNTCGTDFPIKSNAEMV
QALKMLNGRNSMESEVPPKHKETRWKYHFEVVRDTLHLTNKKKDPPPYNLTMFTGNAYIV
ASRDFVQHVLKNPKSQQLIEWVKDTYSPDEHLWATLQRARWMPGSVPNHPKYDISDMTSI
ARLVKWQGHEGDIDKGAPYAPCSGIHQRAICVYGAGDLNWMLQNHHLLANKFDPKVDDNA
LQCLEEYLRYKAIYGTEL

Sequence length

438

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Mucin type O-glycan biosynthesis	O-linked glycosylation of mucins
Metabolic pathways

GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type)

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