Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 382
Gene name ARF GTPase 6
Gene symbol ARF6
Synonyms (NCBI Gene)
-
Chromosome 14
Chromosome location 14q21.3
Summary This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular
miRNA miRNA information provided by mirtarbase database.
1114 Show/Hide all (1114)
miRTarBase ID miRNA Experiments Reference
MIRT021729 hsa-miR-132-3p Microarray 17612493
MIRT021955 hsa-miR-128-3p Microarray 17612493
MIRT025065 hsa-miR-181a-5p Microarray 17612493
MIRT025265 hsa-miR-34a-5p Proteomics 21566225
MIRT026984 hsa-miR-103a-3p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Activation 19642173
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
115 Show/Hide all (115)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000281 Process Mitotic cytokinesis IC 18511905
GO:0001726 Component Ruffle IBA
GO:0001726 Component Ruffle IDA 9312003
GO:0001726 Component Ruffle IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600464 659 ENSG00000165527
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62330
Protein name ADP-ribosylation factor 6 (EC 3.6.5.2)
Protein function GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:16737952, PubMed:18400762, PubMed:21170023, PubMed:32103017, PubMed:7589240). GTP-bound form plays an imp
PDB 1E0S , 2A5D , 2A5F , 2A5G , 2BAO , 2BAU , 2J5X , 2W83 , 3LVQ , 3LVR , 3N5C , 3PCR , 4FME , 4KAX , 6BBP , 6BBQ , 6PAU , 7RK3 , 7XRD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00025 Arf 1 → 173 ADP-ribosylation factor family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}.
Sequence
Sequence length 175
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ras signaling pathway TBC/RABGAPs
Phospholipase D signaling pathway Clathrin-mediated endocytosis
Endocytosis MET receptor recycling
Fc gamma R-mediated phagocytosis  
Pathogenic Escherichia coli infection  
Shigellosis  
Salmonella infection  
Yersinia infection