Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51107
Gene name	Aph-1A gamma-secretase subunit
Gene symbol	APH1A
Synonyms (NCBI Gene)	6530402N02RikAPH-1APH-1ACGI-78
Chromosome	1
Chromosome location	1q21.2
Summary	This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx def

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021538	hsa-miR-145-5p	Reporter assay;Microarray	21351259
MIRT481767	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT383209	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT383208	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT383207	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT481766	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT481765	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT481764	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT481763	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT481762	hsa-miR-302e	PAR-CLIP	23592263
MIRT481761	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT481760	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT481759	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT481758	hsa-miR-520b	PAR-CLIP	23592263
MIRT481757	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT481756	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT481755	hsa-miR-520e	PAR-CLIP	23592263
MIRT481754	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT481753	hsa-miR-4450	PAR-CLIP	23592263
MIRT481752	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT481751	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT481750	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT481749	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT481748	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT481747	hsa-miR-2355-5p	PAR-CLIP	23592263
MIRT481746	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT481745	hsa-miR-1321	PAR-CLIP	23592263
MIRT481743	hsa-miR-4739	PAR-CLIP	23592263
MIRT481744	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT481742	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT481741	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT481740	hsa-miR-7515	PAR-CLIP	23592263
MIRT481739	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT481738	hsa-miR-924	PAR-CLIP	23592263
MIRT481737	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT481736	hsa-miR-3202	PAR-CLIP	23592263
MIRT481735	hsa-miR-3689d	PAR-CLIP	23592263
MIRT481734	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT481732	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT481733	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT481731	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT481730	hsa-miR-4271	PAR-CLIP	23592263
MIRT481729	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT481728	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT481727	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT481726	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT481725	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT481767	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT383209	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT383208	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT383207	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT481766	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT481765	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT481764	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT481763	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT481762	hsa-miR-302e	PAR-CLIP	23592263
MIRT481761	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT481760	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT481759	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT481758	hsa-miR-520b	PAR-CLIP	23592263
MIRT481757	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT481756	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT481755	hsa-miR-520e	PAR-CLIP	23592263
MIRT481754	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT481753	hsa-miR-4450	PAR-CLIP	23592263
MIRT481752	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT481751	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT481750	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT481749	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT481748	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT481747	hsa-miR-2355-5p	PAR-CLIP	23592263
MIRT481746	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT481745	hsa-miR-1321	PAR-CLIP	23592263
MIRT481743	hsa-miR-4739	PAR-CLIP	23592263
MIRT481744	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT481742	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT481741	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT481740	hsa-miR-7515	PAR-CLIP	23592263
MIRT481739	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT481738	hsa-miR-924	PAR-CLIP	23592263
MIRT481737	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT481736	hsa-miR-3202	PAR-CLIP	23592263
MIRT481735	hsa-miR-3689d	PAR-CLIP	23592263
MIRT481734	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT481732	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT481733	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT481731	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT481730	hsa-miR-4271	PAR-CLIP	23592263
MIRT481729	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT481728	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT481727	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT481726	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT481725	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT789129	hsa-let-7a	CLIP-seq
MIRT789130	hsa-let-7b	CLIP-seq
MIRT789131	hsa-let-7c	CLIP-seq
MIRT789132	hsa-let-7d	CLIP-seq
MIRT789133	hsa-let-7e	CLIP-seq
MIRT789134	hsa-let-7f	CLIP-seq
MIRT789135	hsa-let-7g	CLIP-seq
MIRT789136	hsa-let-7i	CLIP-seq
MIRT789137	hsa-miR-1207-5p	CLIP-seq
MIRT789138	hsa-miR-1289	CLIP-seq
MIRT789139	hsa-miR-1302	CLIP-seq
MIRT789140	hsa-miR-1303	CLIP-seq
MIRT789141	hsa-miR-1910	CLIP-seq
MIRT789142	hsa-miR-196a	CLIP-seq
MIRT789143	hsa-miR-196b	CLIP-seq
MIRT789144	hsa-miR-214	CLIP-seq
MIRT789145	hsa-miR-2278	CLIP-seq
MIRT789146	hsa-miR-2392	CLIP-seq
MIRT789147	hsa-miR-24	CLIP-seq
MIRT789148	hsa-miR-299-3p	CLIP-seq
MIRT789149	hsa-miR-302a	CLIP-seq
MIRT789150	hsa-miR-302b	CLIP-seq
MIRT789151	hsa-miR-302c	CLIP-seq
MIRT789152	hsa-miR-302d	CLIP-seq
MIRT789153	hsa-miR-3123	CLIP-seq
MIRT789154	hsa-miR-3132	CLIP-seq
MIRT789155	hsa-miR-3138	CLIP-seq
MIRT789156	hsa-miR-330-3p	CLIP-seq
MIRT789157	hsa-miR-34a	CLIP-seq
MIRT789158	hsa-miR-34c-5p	CLIP-seq
MIRT789159	hsa-miR-3529	CLIP-seq
MIRT789160	hsa-miR-3619-5p	CLIP-seq
MIRT789161	hsa-miR-365	CLIP-seq
MIRT789162	hsa-miR-3662	CLIP-seq
MIRT789163	hsa-miR-3665	CLIP-seq
MIRT789164	hsa-miR-3667-3p	CLIP-seq
MIRT789165	hsa-miR-3690	CLIP-seq
MIRT789166	hsa-miR-372	CLIP-seq
MIRT789167	hsa-miR-373	CLIP-seq
MIRT789168	hsa-miR-378g	CLIP-seq
MIRT789169	hsa-miR-379	CLIP-seq
MIRT789170	hsa-miR-3919	CLIP-seq
MIRT789171	hsa-miR-3937	CLIP-seq
MIRT789172	hsa-miR-4254	CLIP-seq
MIRT789173	hsa-miR-4264	CLIP-seq
MIRT789174	hsa-miR-4265	CLIP-seq
MIRT789175	hsa-miR-4283	CLIP-seq
MIRT789176	hsa-miR-4291	CLIP-seq
MIRT789177	hsa-miR-4296	CLIP-seq
MIRT789178	hsa-miR-4298	CLIP-seq
MIRT789179	hsa-miR-4308	CLIP-seq
MIRT789180	hsa-miR-4322	CLIP-seq
MIRT789181	hsa-miR-4325	CLIP-seq
MIRT789182	hsa-miR-4417	CLIP-seq
MIRT789183	hsa-miR-4428	CLIP-seq
MIRT789184	hsa-miR-4437	CLIP-seq
MIRT789185	hsa-miR-4458	CLIP-seq
MIRT789186	hsa-miR-4468	CLIP-seq
MIRT789187	hsa-miR-4489	CLIP-seq
MIRT789188	hsa-miR-4492	CLIP-seq
MIRT789189	hsa-miR-4498	CLIP-seq
MIRT789190	hsa-miR-449a	CLIP-seq
MIRT789191	hsa-miR-449b	CLIP-seq
MIRT789192	hsa-miR-4500	CLIP-seq
MIRT789193	hsa-miR-4505	CLIP-seq
MIRT789194	hsa-miR-450b-3p	CLIP-seq
MIRT789195	hsa-miR-4514	CLIP-seq
MIRT789196	hsa-miR-4520a-3p	CLIP-seq
MIRT789197	hsa-miR-455-3p	CLIP-seq
MIRT789198	hsa-miR-4638-3p	CLIP-seq
MIRT789199	hsa-miR-4654	CLIP-seq
MIRT789200	hsa-miR-4674	CLIP-seq
MIRT789201	hsa-miR-4692	CLIP-seq
MIRT789202	hsa-miR-4698	CLIP-seq
MIRT789203	hsa-miR-4704-3p	CLIP-seq
MIRT789204	hsa-miR-4705	CLIP-seq
MIRT789205	hsa-miR-4713-3p	CLIP-seq
MIRT789206	hsa-miR-4716-3p	CLIP-seq
MIRT789207	hsa-miR-4719	CLIP-seq
MIRT789208	hsa-miR-4723-5p	CLIP-seq
MIRT789209	hsa-miR-4727-3p	CLIP-seq
MIRT789210	hsa-miR-4731-5p	CLIP-seq
MIRT789211	hsa-miR-4736	CLIP-seq
MIRT789212	hsa-miR-4763-3p	CLIP-seq
MIRT789213	hsa-miR-4769-5p	CLIP-seq
MIRT789214	hsa-miR-519a	CLIP-seq
MIRT789215	hsa-miR-541	CLIP-seq
MIRT789216	hsa-miR-548p	CLIP-seq
MIRT789217	hsa-miR-582-5p	CLIP-seq
MIRT789218	hsa-miR-615-5p	CLIP-seq
MIRT789219	hsa-miR-627	CLIP-seq
MIRT789220	hsa-miR-635	CLIP-seq
MIRT789221	hsa-miR-638	CLIP-seq
MIRT789222	hsa-miR-642b	CLIP-seq
MIRT789223	hsa-miR-711	CLIP-seq
MIRT789224	hsa-miR-761	CLIP-seq
MIRT789225	hsa-miR-762	CLIP-seq
MIRT789226	hsa-miR-769-3p	CLIP-seq
MIRT789227	hsa-miR-922	CLIP-seq
MIRT789228	hsa-miR-940	CLIP-seq
MIRT789229	hsa-miR-98	CLIP-seq
MIRT1932792	hsa-miR-198	CLIP-seq
MIRT1932793	hsa-miR-4775	CLIP-seq
MIRT1932794	hsa-miR-4779	CLIP-seq
MIRT1932795	hsa-miR-539	CLIP-seq
MIRT789129	hsa-let-7a	CLIP-seq
MIRT789130	hsa-let-7b	CLIP-seq
MIRT789131	hsa-let-7c	CLIP-seq
MIRT789132	hsa-let-7d	CLIP-seq
MIRT789133	hsa-let-7e	CLIP-seq
MIRT789134	hsa-let-7f	CLIP-seq
MIRT789135	hsa-let-7g	CLIP-seq
MIRT789136	hsa-let-7i	CLIP-seq
MIRT1932796	hsa-miR-1270	CLIP-seq
MIRT1932797	hsa-miR-1273f	CLIP-seq
MIRT789138	hsa-miR-1289	CLIP-seq
MIRT789140	hsa-miR-1303	CLIP-seq
MIRT789142	hsa-miR-196a	CLIP-seq
MIRT789143	hsa-miR-196b	CLIP-seq
MIRT789147	hsa-miR-24	CLIP-seq
MIRT789149	hsa-miR-302a	CLIP-seq
MIRT789150	hsa-miR-302b	CLIP-seq
MIRT789151	hsa-miR-302c	CLIP-seq
MIRT789152	hsa-miR-302d	CLIP-seq
MIRT1932798	hsa-miR-3064-5p	CLIP-seq
MIRT1932799	hsa-miR-3131	CLIP-seq
MIRT789154	hsa-miR-3132	CLIP-seq
MIRT789155	hsa-miR-3138	CLIP-seq
MIRT1932800	hsa-miR-320a	CLIP-seq
MIRT1932801	hsa-miR-320b	CLIP-seq
MIRT1932802	hsa-miR-320c	CLIP-seq
MIRT1932803	hsa-miR-320d	CLIP-seq
MIRT789156	hsa-miR-330-3p	CLIP-seq
MIRT789157	hsa-miR-34a	CLIP-seq
MIRT789158	hsa-miR-34c-5p	CLIP-seq
MIRT789159	hsa-miR-3529	CLIP-seq
MIRT789163	hsa-miR-3665	CLIP-seq
MIRT789165	hsa-miR-3690	CLIP-seq
MIRT789166	hsa-miR-372	CLIP-seq
MIRT789167	hsa-miR-373	CLIP-seq
MIRT789168	hsa-miR-378g	CLIP-seq
MIRT789169	hsa-miR-379	CLIP-seq
MIRT789172	hsa-miR-4254	CLIP-seq
MIRT789173	hsa-miR-4264	CLIP-seq
MIRT1932804	hsa-miR-4268	CLIP-seq
MIRT789175	hsa-miR-4283	CLIP-seq
MIRT789179	hsa-miR-4308	CLIP-seq
MIRT1932805	hsa-miR-4420	CLIP-seq
MIRT1932806	hsa-miR-4429	CLIP-seq
MIRT1932807	hsa-miR-4434	CLIP-seq
MIRT789184	hsa-miR-4437	CLIP-seq
MIRT1932808	hsa-miR-4448	CLIP-seq
MIRT789185	hsa-miR-4458	CLIP-seq
MIRT789187	hsa-miR-4489	CLIP-seq
MIRT1932809	hsa-miR-4490	CLIP-seq
MIRT789188	hsa-miR-4492	CLIP-seq
MIRT789189	hsa-miR-4498	CLIP-seq
MIRT789190	hsa-miR-449a	CLIP-seq
MIRT789191	hsa-miR-449b	CLIP-seq
MIRT789192	hsa-miR-4500	CLIP-seq
MIRT789193	hsa-miR-4505	CLIP-seq
MIRT789194	hsa-miR-450b-3p	CLIP-seq
MIRT789195	hsa-miR-4514	CLIP-seq
MIRT1932810	hsa-miR-4516	CLIP-seq
MIRT789196	hsa-miR-4520a-3p	CLIP-seq
MIRT1932811	hsa-miR-4531	CLIP-seq
MIRT1932812	hsa-miR-4534	CLIP-seq
MIRT789198	hsa-miR-4638-3p	CLIP-seq
MIRT1932813	hsa-miR-4649-5p	CLIP-seq
MIRT789199	hsa-miR-4654	CLIP-seq
MIRT789200	hsa-miR-4674	CLIP-seq
MIRT1932814	hsa-miR-4683	CLIP-seq
MIRT789201	hsa-miR-4692	CLIP-seq
MIRT789203	hsa-miR-4704-3p	CLIP-seq
MIRT789204	hsa-miR-4705	CLIP-seq
MIRT789205	hsa-miR-4713-3p	CLIP-seq
MIRT789206	hsa-miR-4716-3p	CLIP-seq
MIRT789207	hsa-miR-4719	CLIP-seq
MIRT789208	hsa-miR-4723-5p	CLIP-seq
MIRT789209	hsa-miR-4727-3p	CLIP-seq
MIRT789211	hsa-miR-4736	CLIP-seq
MIRT789213	hsa-miR-4769-5p	CLIP-seq
MIRT1932794	hsa-miR-4779	CLIP-seq
MIRT789214	hsa-miR-519a	CLIP-seq
MIRT1932795	hsa-miR-539	CLIP-seq
MIRT789215	hsa-miR-541	CLIP-seq
MIRT789216	hsa-miR-548p	CLIP-seq
MIRT1932815	hsa-miR-611	CLIP-seq
MIRT789218	hsa-miR-615-5p	CLIP-seq
MIRT1932816	hsa-miR-620	CLIP-seq
MIRT789221	hsa-miR-638	CLIP-seq
MIRT789222	hsa-miR-642b	CLIP-seq
MIRT789225	hsa-miR-762	CLIP-seq
MIRT789226	hsa-miR-769-3p	CLIP-seq
MIRT1932817	hsa-miR-892b	CLIP-seq
MIRT789228	hsa-miR-940	CLIP-seq
MIRT789229	hsa-miR-98	CLIP-seq
MIRT2172974	hsa-miR-1228	CLIP-seq
MIRT789138	hsa-miR-1289	CLIP-seq
MIRT789139	hsa-miR-1302	CLIP-seq
MIRT2172975	hsa-miR-145	CLIP-seq
MIRT2172976	hsa-miR-188-3p	CLIP-seq
MIRT2172977	hsa-miR-204	CLIP-seq
MIRT2172978	hsa-miR-211	CLIP-seq
MIRT789144	hsa-miR-214	CLIP-seq
MIRT789146	hsa-miR-2392	CLIP-seq
MIRT789149	hsa-miR-302a	CLIP-seq
MIRT789150	hsa-miR-302b	CLIP-seq
MIRT789151	hsa-miR-302c	CLIP-seq
MIRT789152	hsa-miR-302d	CLIP-seq
MIRT1932798	hsa-miR-3064-5p	CLIP-seq
MIRT1932800	hsa-miR-320a	CLIP-seq
MIRT1932801	hsa-miR-320b	CLIP-seq
MIRT1932802	hsa-miR-320c	CLIP-seq
MIRT1932803	hsa-miR-320d	CLIP-seq
MIRT789156	hsa-miR-330-3p	CLIP-seq
MIRT789160	hsa-miR-3619-5p	CLIP-seq
MIRT2172979	hsa-miR-362-5p	CLIP-seq
MIRT789161	hsa-miR-365	CLIP-seq
MIRT789162	hsa-miR-3662	CLIP-seq
MIRT789164	hsa-miR-3667-3p	CLIP-seq
MIRT2172980	hsa-miR-3670	CLIP-seq
MIRT2172981	hsa-miR-3679-3p	CLIP-seq
MIRT789165	hsa-miR-3690	CLIP-seq
MIRT789166	hsa-miR-372	CLIP-seq
MIRT789167	hsa-miR-373	CLIP-seq
MIRT2172982	hsa-miR-4251	CLIP-seq
MIRT789172	hsa-miR-4254	CLIP-seq
MIRT1932804	hsa-miR-4268	CLIP-seq
MIRT789176	hsa-miR-4291	CLIP-seq
MIRT789178	hsa-miR-4298	CLIP-seq
MIRT789181	hsa-miR-4325	CLIP-seq
MIRT1932806	hsa-miR-4429	CLIP-seq
MIRT1932808	hsa-miR-4448	CLIP-seq
MIRT1932809	hsa-miR-4490	CLIP-seq
MIRT789198	hsa-miR-4638-3p	CLIP-seq
MIRT789203	hsa-miR-4704-3p	CLIP-seq
MIRT789204	hsa-miR-4705	CLIP-seq
MIRT2172983	hsa-miR-4712-5p	CLIP-seq
MIRT789206	hsa-miR-4716-3p	CLIP-seq
MIRT789207	hsa-miR-4719	CLIP-seq
MIRT789208	hsa-miR-4723-5p	CLIP-seq
MIRT2172984	hsa-miR-4749-3p	CLIP-seq
MIRT2172985	hsa-miR-500b	CLIP-seq
MIRT2172986	hsa-miR-501-5p	CLIP-seq
MIRT789214	hsa-miR-519a	CLIP-seq
MIRT2172987	hsa-miR-522	CLIP-seq
MIRT2172988	hsa-miR-532-3p	CLIP-seq
MIRT1932795	hsa-miR-539	CLIP-seq
MIRT789215	hsa-miR-541	CLIP-seq
MIRT2172989	hsa-miR-548aa	CLIP-seq
MIRT2172990	hsa-miR-578	CLIP-seq
MIRT789217	hsa-miR-582-5p	CLIP-seq
MIRT789218	hsa-miR-615-5p	CLIP-seq
MIRT789222	hsa-miR-642b	CLIP-seq
MIRT789224	hsa-miR-761	CLIP-seq
MIRT2172991	hsa-miR-770-5p	CLIP-seq
MIRT1932817	hsa-miR-892b	CLIP-seq
MIRT789227	hsa-miR-922	CLIP-seq
MIRT789138	hsa-miR-1289	CLIP-seq
MIRT789165	hsa-miR-3690	CLIP-seq
MIRT789172	hsa-miR-4254	CLIP-seq
MIRT789198	hsa-miR-4638-3p	CLIP-seq
MIRT789206	hsa-miR-4716-3p	CLIP-seq
MIRT789208	hsa-miR-4723-5p	CLIP-seq
MIRT789218	hsa-miR-615-5p	CLIP-seq
MIRT789222	hsa-miR-642b	CLIP-seq
MIRT789138	hsa-miR-1289	CLIP-seq
MIRT789165	hsa-miR-3690	CLIP-seq
MIRT789172	hsa-miR-4254	CLIP-seq
MIRT789198	hsa-miR-4638-3p	CLIP-seq
MIRT789206	hsa-miR-4716-3p	CLIP-seq
MIRT789208	hsa-miR-4723-5p	CLIP-seq
MIRT789222	hsa-miR-642b	CLIP-seq
MIRT2476170	hsa-miR-1184	CLIP-seq
MIRT2476171	hsa-miR-122	CLIP-seq
MIRT1932796	hsa-miR-1270	CLIP-seq
MIRT1932797	hsa-miR-1273f	CLIP-seq
MIRT2476172	hsa-miR-1301	CLIP-seq
MIRT2476173	hsa-miR-136	CLIP-seq
MIRT2476174	hsa-miR-138	CLIP-seq
MIRT2476175	hsa-miR-140-3p	CLIP-seq
MIRT2172975	hsa-miR-145	CLIP-seq
MIRT2476176	hsa-miR-182	CLIP-seq
MIRT2476177	hsa-miR-1825	CLIP-seq
MIRT2476178	hsa-miR-197	CLIP-seq
MIRT1932792	hsa-miR-198	CLIP-seq
MIRT2476179	hsa-miR-199a-5p	CLIP-seq
MIRT2476180	hsa-miR-199b-5p	CLIP-seq
MIRT2172977	hsa-miR-204	CLIP-seq
MIRT2172978	hsa-miR-211	CLIP-seq
MIRT2476181	hsa-miR-2110	CLIP-seq
MIRT2476182	hsa-miR-3065-3p	CLIP-seq
MIRT1932799	hsa-miR-3131	CLIP-seq
MIRT2476183	hsa-miR-3150a-3p	CLIP-seq
MIRT2476184	hsa-miR-3173-3p	CLIP-seq
MIRT2476185	hsa-miR-3175	CLIP-seq
MIRT2476186	hsa-miR-3189-3p	CLIP-seq
MIRT2476187	hsa-miR-323-5p	CLIP-seq
MIRT2172979	hsa-miR-362-5p	CLIP-seq
MIRT789161	hsa-miR-365	CLIP-seq
MIRT2172980	hsa-miR-3670	CLIP-seq
MIRT2476188	hsa-miR-3677-5p	CLIP-seq
MIRT2476189	hsa-miR-3925-3p	CLIP-seq
MIRT2476190	hsa-miR-412	CLIP-seq
MIRT2476191	hsa-miR-4267	CLIP-seq
MIRT789181	hsa-miR-4325	CLIP-seq
MIRT2476192	hsa-miR-4418	CLIP-seq
MIRT789183	hsa-miR-4428	CLIP-seq
MIRT1932807	hsa-miR-4434	CLIP-seq
MIRT2476193	hsa-miR-4435	CLIP-seq
MIRT2476194	hsa-miR-4436b-5p	CLIP-seq
MIRT2476195	hsa-miR-4456	CLIP-seq
MIRT2476196	hsa-miR-4477b	CLIP-seq
MIRT1932810	hsa-miR-4516	CLIP-seq
MIRT1932811	hsa-miR-4531	CLIP-seq
MIRT1932812	hsa-miR-4534	CLIP-seq
MIRT1932813	hsa-miR-4649-5p	CLIP-seq
MIRT2476197	hsa-miR-4660	CLIP-seq
MIRT1932814	hsa-miR-4683	CLIP-seq
MIRT2476198	hsa-miR-4685-5p	CLIP-seq
MIRT2476199	hsa-miR-4691-5p	CLIP-seq
MIRT2172983	hsa-miR-4712-5p	CLIP-seq
MIRT1932793	hsa-miR-4775	CLIP-seq
MIRT1932794	hsa-miR-4779	CLIP-seq
MIRT2476200	hsa-miR-4793-3p	CLIP-seq
MIRT2172985	hsa-miR-500b	CLIP-seq
MIRT2172986	hsa-miR-501-5p	CLIP-seq
MIRT2476201	hsa-miR-5047	CLIP-seq
MIRT2476202	hsa-miR-509-3-5p	CLIP-seq
MIRT2476203	hsa-miR-509-5p	CLIP-seq
MIRT2476204	hsa-miR-516b	CLIP-seq
MIRT1932795	hsa-miR-539	CLIP-seq
MIRT2172989	hsa-miR-548aa	CLIP-seq
MIRT2172990	hsa-miR-578	CLIP-seq
MIRT1932815	hsa-miR-611	CLIP-seq
MIRT1932816	hsa-miR-620	CLIP-seq
MIRT2476205	hsa-miR-766	CLIP-seq
MIRT2172991	hsa-miR-770-5p	CLIP-seq
MIRT2476206	hsa-miR-876-3p	CLIP-seq
MIRT2476207	hsa-miR-885-5p	CLIP-seq
MIRT2476208	hsa-miR-939	CLIP-seq
MIRT2476170	hsa-miR-1184	CLIP-seq
MIRT2476171	hsa-miR-122	CLIP-seq
MIRT1932796	hsa-miR-1270	CLIP-seq
MIRT1932797	hsa-miR-1273f	CLIP-seq
MIRT2476172	hsa-miR-1301	CLIP-seq
MIRT2476173	hsa-miR-136	CLIP-seq
MIRT2476174	hsa-miR-138	CLIP-seq
MIRT2476175	hsa-miR-140-3p	CLIP-seq
MIRT2476176	hsa-miR-182	CLIP-seq
MIRT2476177	hsa-miR-1825	CLIP-seq
MIRT2476178	hsa-miR-197	CLIP-seq
MIRT1932792	hsa-miR-198	CLIP-seq
MIRT2476179	hsa-miR-199a-5p	CLIP-seq
MIRT2476180	hsa-miR-199b-5p	CLIP-seq
MIRT2172977	hsa-miR-204	CLIP-seq
MIRT2172978	hsa-miR-211	CLIP-seq
MIRT2476181	hsa-miR-2110	CLIP-seq
MIRT2476182	hsa-miR-3065-3p	CLIP-seq
MIRT2476183	hsa-miR-3150a-3p	CLIP-seq
MIRT2476184	hsa-miR-3173-3p	CLIP-seq
MIRT2476185	hsa-miR-3175	CLIP-seq
MIRT2476186	hsa-miR-3189-3p	CLIP-seq
MIRT2476187	hsa-miR-323-5p	CLIP-seq
MIRT2172979	hsa-miR-362-5p	CLIP-seq
MIRT2172980	hsa-miR-3670	CLIP-seq
MIRT2476188	hsa-miR-3677-5p	CLIP-seq
MIRT2476189	hsa-miR-3925-3p	CLIP-seq
MIRT2476190	hsa-miR-412	CLIP-seq
MIRT2476191	hsa-miR-4267	CLIP-seq
MIRT2476192	hsa-miR-4418	CLIP-seq
MIRT789183	hsa-miR-4428	CLIP-seq
MIRT1932807	hsa-miR-4434	CLIP-seq
MIRT2476193	hsa-miR-4435	CLIP-seq
MIRT2476194	hsa-miR-4436b-5p	CLIP-seq
MIRT2476195	hsa-miR-4456	CLIP-seq
MIRT2476196	hsa-miR-4477b	CLIP-seq
MIRT1932810	hsa-miR-4516	CLIP-seq
MIRT1932811	hsa-miR-4531	CLIP-seq
MIRT1932812	hsa-miR-4534	CLIP-seq
MIRT1932813	hsa-miR-4649-5p	CLIP-seq
MIRT2476197	hsa-miR-4660	CLIP-seq
MIRT1932814	hsa-miR-4683	CLIP-seq
MIRT2476198	hsa-miR-4685-5p	CLIP-seq
MIRT2476199	hsa-miR-4691-5p	CLIP-seq
MIRT1932793	hsa-miR-4775	CLIP-seq
MIRT1932794	hsa-miR-4779	CLIP-seq
MIRT2476200	hsa-miR-4793-3p	CLIP-seq
MIRT2172985	hsa-miR-500b	CLIP-seq
MIRT2172986	hsa-miR-501-5p	CLIP-seq
MIRT2476201	hsa-miR-5047	CLIP-seq
MIRT2476202	hsa-miR-509-3-5p	CLIP-seq
MIRT2476203	hsa-miR-509-5p	CLIP-seq
MIRT2476204	hsa-miR-516b	CLIP-seq
MIRT1932795	hsa-miR-539	CLIP-seq
MIRT2172989	hsa-miR-548aa	CLIP-seq
MIRT2172990	hsa-miR-578	CLIP-seq
MIRT1932816	hsa-miR-620	CLIP-seq
MIRT2476205	hsa-miR-766	CLIP-seq
MIRT2476206	hsa-miR-876-3p	CLIP-seq
MIRT2476207	hsa-miR-885-5p	CLIP-seq
MIRT2476208	hsa-miR-939	CLIP-seq

Transcription factor	Regulation	Reference
YY1	Activation	21443683

60 Show/Hide all (60)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	NAS	15274632
GO:0001656	Process	Metanephros development	IEA
GO:0005515	Function	Protein binding	IPI	12297508, 18201567, 19376115, 25394380, 26280335, 30559186, 32296183, 32814053
GO:0005769	Component	Early endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	15274632
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	15274632
GO:0005794	Component	Golgi apparatus	IDA	15274632
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	15274632
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IDA	15274632
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007220	Process	Notch receptor processing	IBA
GO:0007220	Process	Notch receptor processing	IDA	27608597
GO:0007220	Process	Notch receptor processing	IEA
GO:0007220	Process	Notch receptor processing	IMP	12297508
GO:0007220	Process	Notch receptor processing	NAS	10206645
GO:0007220	Process	Notch receptor processing	TAS	15274632
GO:0008021	Component	Synaptic vesicle	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	25043039, 26280335
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016485	Process	Protein processing	IDA	15274632, 27608597
GO:0016485	Process	Protein processing	IEA
GO:0016485	Process	Protein processing	IGI	12763021
GO:0016485	Process	Protein processing	IMP	12297508
GO:0019899	Function	Enzyme binding	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0030674	Function	Protein-macromolecule adaptor activity	IMP	12297508
GO:0031293	Process	Membrane protein intracellular domain proteolysis	IDA	15274632
GO:0031293	Process	Membrane protein intracellular domain proteolysis	IMP	12297508
GO:0031293	Process	Membrane protein intracellular domain proteolysis	ISS
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0034205	Process	Amyloid-beta formation	IDA	27608597
GO:0034205	Process	Amyloid-beta formation	IGI	12763021
GO:0034205	Process	Amyloid-beta formation	IMP	12297508, 25043039, 26280335
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042982	Process	Amyloid precursor protein metabolic process	IDA	25043039, 26280335
GO:0042987	Process	Amyloid precursor protein catabolic process	IDA	15274632, 27608597
GO:0042987	Process	Amyloid precursor protein catabolic process	IGI	12763021
GO:0042987	Process	Amyloid precursor protein catabolic process	IMP	12297508
GO:0042987	Process	Amyloid precursor protein catabolic process	ISS
GO:0042987	Process	Amyloid precursor protein catabolic process	TAS	15274632
GO:0061133	Function	Endopeptidase activator activity	IEA
GO:0061133	Function	Endopeptidase activator activity	IGI	12763021
GO:0061133	Function	Endopeptidase activator activity	IMP	12297508
GO:0070765	Component	Gamma-secretase complex	IBA
GO:0070765	Component	Gamma-secretase complex	IDA	12297508, 25043039, 26280335
GO:0070765	Component	Gamma-secretase complex	IEA
GO:0070765	Component	Gamma-secretase complex	IPI	26280335
GO:0070765	Component	Gamma-secretase complex	ISS
GO:0097060	Component	Synaptic membrane	IEA

MIM	HGNC	e!Ensembl
607629	29509	ENSG00000117362

Q96BI3

Protein name

Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)

Protein function

Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522

PDB

5A63 , 5FN2 , 5FN3 , 5FN4 , 5FN5 , 6IDF , 6IYC , 6LQG , 6LR4 , 7C9I , 7D8X , 7Y5T , 7Y5X , 7Y5Z , 8IM7 , 8K8E , 8KCO , 8KCP , 8KCS , 8KCT , 8KCU , 8X52 , 8X53 , 8X54

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06105	Aph-1	2 → 239	Aph-1 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level. {ECO:0000269|PubMed:12110170}.

Sequence

MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
RSLLCRRQEDSRVMVYSALRIPPED

Sequence length

265

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Notch signaling pathway	Nuclear signaling by ERBB4
Alzheimer disease	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	EPH-ephrin mediated repulsion of cells
	NOTCH3 Activation and Transmission of Signal to the Nucleus
	Noncanonical activation of NOTCH3
	Amyloid fiber formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
APH1A-related disorder	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (28)
Acne	Acne	BEFREE	30577530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acne Vulgaris	Acne	BEFREE	30577530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	9605951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	21443683	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	26293690		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	26334913		★★★★★ ★☆☆☆☆ Found in Text Mining only
Androgen-Insensitivity Syndrome	Androgen-Insensitivity Syndrome	BEFREE	30030189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	37717070	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astigmatism	Astigmatism	BEFREE	28656103		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Palsy	Cerebral palsy	BEFREE	31306277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	31130312, 31826895		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	21504709, 28315422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	11771760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelioma	Epithelioma	BEFREE	28315422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	6146037		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasm	Kidney Neoplasm	BEFREE	25582502		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	19809274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19625619, 19805375, 19855157, 29212731		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	30594961		★★★★★ ★☆☆☆☆ Found in Text Mining only
MiT family translocation renal cell carcinoma	Renal Carcinoma	BEFREE	23628822, 28315422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19805375, 19809274, 19855157, 23644382, 29799303		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	19606011		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	2687298		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary Renal Cell Carcinoma	Papillary Renal Carcinoma	BEFREE	9393982		★★★★★ ★☆☆☆☆ Found in Text Mining only
Perivascular Epithelioid Cell Neoplasms	Perivascular Epithelioid Neoplasms	BEFREE	19606011		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pituitary Diseases	Pituitary Diseases	BEFREE	8473291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	19809274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	11313942, 21504709, 28315422, 9393982		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NCSTN	[]	10	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Amyloid fiber formation","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	[]
PSENEN	[]	10	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Amyloid fiber formation","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	[]
APH1B	[]	10	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Amyloid fiber formation","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	[]
PSEN2	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	[]
PSEN1	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	[]

APH1A (aph-1A gamma-secretase subunit)

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