APH1B (aph-1B gamma-secretase subunit)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83464
• Gene name: Aph-1B gamma-secretase subunit
• Gene symbol: APH1B
• Synonyms (NCBI Gene): APH-1B, PRO1328, PSFL, TAAV688, aph-1beta
• Chromosome: 15
• Chromosome location: 15q22.2
• Summary: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex.

miRNA Show/Hide all (431)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019680	hsa-miR-375	Microarray	20215506
MIRT789230	hsa-miR-105	CLIP-seq
MIRT789231	hsa-miR-1226	CLIP-seq
MIRT789232	hsa-miR-124	CLIP-seq
MIRT789233	hsa-miR-1253	CLIP-seq
MIRT789234	hsa-miR-1257	CLIP-seq
MIRT789235	hsa-miR-1290	CLIP-seq
MIRT789236	hsa-miR-1292	CLIP-seq
MIRT789237	hsa-miR-129-3p	CLIP-seq
MIRT789238	hsa-miR-134	CLIP-seq
MIRT789239	hsa-miR-137	CLIP-seq
MIRT789240	hsa-miR-139-5p	CLIP-seq
MIRT789241	hsa-miR-141	CLIP-seq
MIRT789242	hsa-miR-147	CLIP-seq
MIRT789243	hsa-miR-15a	CLIP-seq
MIRT789244	hsa-miR-15b	CLIP-seq
MIRT789245	hsa-miR-16	CLIP-seq
MIRT789246	hsa-miR-1909	CLIP-seq
MIRT789247	hsa-miR-195	CLIP-seq
MIRT789248	hsa-miR-200a	CLIP-seq
MIRT789249	hsa-miR-21	CLIP-seq
MIRT789250	hsa-miR-2113	CLIP-seq
MIRT789251	hsa-miR-2117	CLIP-seq
MIRT789252	hsa-miR-2278	CLIP-seq
MIRT789253	hsa-miR-23a	CLIP-seq
MIRT789254	hsa-miR-23b	CLIP-seq
MIRT789255	hsa-miR-23c	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789257	hsa-miR-25	CLIP-seq
MIRT789258	hsa-miR-28-3p	CLIP-seq
MIRT789259	hsa-miR-2964a-3p	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789261	hsa-miR-3118	CLIP-seq
MIRT789262	hsa-miR-3120-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789264	hsa-miR-3164	CLIP-seq
MIRT789265	hsa-miR-32	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT789269	hsa-miR-3613-3p	CLIP-seq
MIRT789270	hsa-miR-361-5p	CLIP-seq
MIRT789271	hsa-miR-3617	CLIP-seq
MIRT789272	hsa-miR-3622a-3p	CLIP-seq
MIRT789273	hsa-miR-3622a-5p	CLIP-seq
MIRT789274	hsa-miR-3622b-3p	CLIP-seq
MIRT789275	hsa-miR-363	CLIP-seq
MIRT789276	hsa-miR-3646	CLIP-seq
MIRT789277	hsa-miR-3651	CLIP-seq
MIRT789278	hsa-miR-367	CLIP-seq
MIRT789279	hsa-miR-3671	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT789283	hsa-miR-424	CLIP-seq
MIRT789284	hsa-miR-4263	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT789286	hsa-miR-4272	CLIP-seq
MIRT789287	hsa-miR-4273	CLIP-seq
MIRT789288	hsa-miR-4279	CLIP-seq
MIRT789289	hsa-miR-4310	CLIP-seq
MIRT789290	hsa-miR-4426	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789292	hsa-miR-4461	CLIP-seq
MIRT789293	hsa-miR-4468	CLIP-seq
MIRT789294	hsa-miR-4471	CLIP-seq
MIRT789295	hsa-miR-4480	CLIP-seq
MIRT789296	hsa-miR-4484	CLIP-seq
MIRT789297	hsa-miR-4494	CLIP-seq
MIRT789298	hsa-miR-452	CLIP-seq
MIRT789299	hsa-miR-4528	CLIP-seq
MIRT789300	hsa-miR-4646-5p	CLIP-seq
MIRT789301	hsa-miR-4647	CLIP-seq
MIRT789302	hsa-miR-4659a-3p	CLIP-seq
MIRT789303	hsa-miR-4659b-3p	CLIP-seq
MIRT789304	hsa-miR-4662b	CLIP-seq
MIRT789305	hsa-miR-4676-3p	CLIP-seq
MIRT789306	hsa-miR-4687-5p	CLIP-seq
MIRT789307	hsa-miR-4698	CLIP-seq
MIRT789308	hsa-miR-4714-3p	CLIP-seq
MIRT789309	hsa-miR-4717-3p	CLIP-seq
MIRT789310	hsa-miR-4722-3p	CLIP-seq
MIRT789311	hsa-miR-4760-3p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT789313	hsa-miR-4778-3p	CLIP-seq
MIRT789314	hsa-miR-4790-3p	CLIP-seq
MIRT789315	hsa-miR-4794	CLIP-seq
MIRT789316	hsa-miR-4795-3p	CLIP-seq
MIRT789317	hsa-miR-4797-5p	CLIP-seq
MIRT789318	hsa-miR-4800-3p	CLIP-seq
MIRT789319	hsa-miR-497	CLIP-seq
MIRT789320	hsa-miR-499a-5p	CLIP-seq
MIRT789321	hsa-miR-506	CLIP-seq
MIRT789322	hsa-miR-513c	CLIP-seq
MIRT789323	hsa-miR-514b-5p	CLIP-seq
MIRT789324	hsa-miR-545	CLIP-seq
MIRT789325	hsa-miR-548an	CLIP-seq
MIRT789326	hsa-miR-548p	CLIP-seq
MIRT789327	hsa-miR-568	CLIP-seq
MIRT789328	hsa-miR-576-5p	CLIP-seq
MIRT789329	hsa-miR-577	CLIP-seq
MIRT789330	hsa-miR-580	CLIP-seq
MIRT789331	hsa-miR-590-5p	CLIP-seq
MIRT789332	hsa-miR-604	CLIP-seq
MIRT789333	hsa-miR-607	CLIP-seq
MIRT789334	hsa-miR-617	CLIP-seq
MIRT789335	hsa-miR-633	CLIP-seq
MIRT789336	hsa-miR-641	CLIP-seq
MIRT789337	hsa-miR-647	CLIP-seq
MIRT789338	hsa-miR-758	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT789340	hsa-miR-892b	CLIP-seq
MIRT789341	hsa-miR-92a	CLIP-seq
MIRT789342	hsa-miR-92b	CLIP-seq
MIRT789343	hsa-miR-122	CLIP-seq
MIRT789344	hsa-miR-1258	CLIP-seq
MIRT789242	hsa-miR-147	CLIP-seq
MIRT789345	hsa-miR-181a	CLIP-seq
MIRT789346	hsa-miR-181b	CLIP-seq
MIRT789347	hsa-miR-181c	CLIP-seq
MIRT789348	hsa-miR-181d	CLIP-seq
MIRT789249	hsa-miR-21	CLIP-seq
MIRT789349	hsa-miR-219-1-3p	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789258	hsa-miR-28-3p	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789350	hsa-miR-3140-5p	CLIP-seq
MIRT789351	hsa-miR-3165	CLIP-seq
MIRT789352	hsa-miR-3202	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT789353	hsa-miR-3618	CLIP-seq
MIRT789354	hsa-miR-3655	CLIP-seq
MIRT789355	hsa-miR-3675-3p	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789356	hsa-miR-3919	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT789357	hsa-miR-4254	CLIP-seq
MIRT789358	hsa-miR-4262	CLIP-seq
MIRT789359	hsa-miR-4266	CLIP-seq
MIRT789360	hsa-miR-4420	CLIP-seq
MIRT789361	hsa-miR-4424	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789362	hsa-miR-4504	CLIP-seq
MIRT789363	hsa-miR-4533	CLIP-seq
MIRT789364	hsa-miR-4653-3p	CLIP-seq
MIRT789365	hsa-miR-4668-3p	CLIP-seq
MIRT789366	hsa-miR-4756-3p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT789314	hsa-miR-4790-3p	CLIP-seq
MIRT789367	hsa-miR-489	CLIP-seq
MIRT789368	hsa-miR-514	CLIP-seq
MIRT789369	hsa-miR-514b-3p	CLIP-seq
MIRT789370	hsa-miR-542-3p	CLIP-seq
MIRT789371	hsa-miR-543	CLIP-seq
MIRT789327	hsa-miR-568	CLIP-seq
MIRT789372	hsa-miR-570	CLIP-seq
MIRT789328	hsa-miR-576-5p	CLIP-seq
MIRT789331	hsa-miR-590-5p	CLIP-seq
MIRT789373	hsa-miR-619	CLIP-seq
MIRT789374	hsa-miR-767-3p	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT789375	hsa-miR-934	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT1932818	hsa-miR-3664-3p	CLIP-seq
MIRT1932819	hsa-miR-145	CLIP-seq
MIRT789242	hsa-miR-147	CLIP-seq
MIRT789345	hsa-miR-181a	CLIP-seq
MIRT789346	hsa-miR-181b	CLIP-seq
MIRT789347	hsa-miR-181c	CLIP-seq
MIRT789348	hsa-miR-181d	CLIP-seq
MIRT789252	hsa-miR-2278	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT1932820	hsa-miR-3189-3p	CLIP-seq
MIRT1932821	hsa-miR-338-5p	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT789270	hsa-miR-361-5p	CLIP-seq
MIRT789272	hsa-miR-3622a-3p	CLIP-seq
MIRT789274	hsa-miR-3622b-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT789358	hsa-miR-4262	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789299	hsa-miR-4528	CLIP-seq
MIRT789300	hsa-miR-4646-5p	CLIP-seq
MIRT789302	hsa-miR-4659a-3p	CLIP-seq
MIRT789303	hsa-miR-4659b-3p	CLIP-seq
MIRT1932822	hsa-miR-4686	CLIP-seq
MIRT1932823	hsa-miR-4747-5p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT1932824	hsa-miR-486-5p	CLIP-seq
MIRT789367	hsa-miR-489	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT789368	hsa-miR-514	CLIP-seq
MIRT789369	hsa-miR-514b-3p	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT1932826	hsa-miR-942	CLIP-seq
MIRT2172992	hsa-miR-1208	CLIP-seq
MIRT2172993	hsa-miR-1236	CLIP-seq
MIRT789344	hsa-miR-1258	CLIP-seq
MIRT789239	hsa-miR-137	CLIP-seq
MIRT789253	hsa-miR-23a	CLIP-seq
MIRT789254	hsa-miR-23b	CLIP-seq
MIRT789255	hsa-miR-23c	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT789257	hsa-miR-25	CLIP-seq
MIRT789258	hsa-miR-28-3p	CLIP-seq
MIRT789259	hsa-miR-2964a-3p	CLIP-seq
MIRT789260	hsa-miR-3074-3p	CLIP-seq
MIRT789262	hsa-miR-3120-3p	CLIP-seq
MIRT789263	hsa-miR-3127-5p	CLIP-seq
MIRT789265	hsa-miR-32	CLIP-seq
MIRT789352	hsa-miR-3202	CLIP-seq
MIRT1932821	hsa-miR-338-5p	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT789268	hsa-miR-342-3p	CLIP-seq
MIRT2172994	hsa-miR-3613-5p	CLIP-seq
MIRT789270	hsa-miR-361-5p	CLIP-seq
MIRT789271	hsa-miR-3617	CLIP-seq
MIRT789353	hsa-miR-3618	CLIP-seq
MIRT2172995	hsa-miR-362-5p	CLIP-seq
MIRT789275	hsa-miR-363	CLIP-seq
MIRT789354	hsa-miR-3655	CLIP-seq
MIRT789278	hsa-miR-367	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT789281	hsa-miR-3918	CLIP-seq
MIRT789357	hsa-miR-4254	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT2172996	hsa-miR-4269	CLIP-seq
MIRT789286	hsa-miR-4272	CLIP-seq
MIRT789289	hsa-miR-4310	CLIP-seq
MIRT789360	hsa-miR-4420	CLIP-seq
MIRT789291	hsa-miR-4437	CLIP-seq
MIRT789297	hsa-miR-4494	CLIP-seq
MIRT2172997	hsa-miR-4514	CLIP-seq
MIRT789298	hsa-miR-452	CLIP-seq
MIRT2172998	hsa-miR-4522	CLIP-seq
MIRT789299	hsa-miR-4528	CLIP-seq
MIRT789363	hsa-miR-4533	CLIP-seq
MIRT789364	hsa-miR-4653-3p	CLIP-seq
MIRT789305	hsa-miR-4676-3p	CLIP-seq
MIRT2172999	hsa-miR-4676-5p	CLIP-seq
MIRT2173000	hsa-miR-4692	CLIP-seq
MIRT789309	hsa-miR-4717-3p	CLIP-seq
MIRT2173001	hsa-miR-4724-3p	CLIP-seq
MIRT2173002	hsa-miR-4742-5p	CLIP-seq
MIRT789312	hsa-miR-4764-3p	CLIP-seq
MIRT2173003	hsa-miR-4789-5p	CLIP-seq
MIRT789314	hsa-miR-4790-3p	CLIP-seq
MIRT789316	hsa-miR-4795-3p	CLIP-seq
MIRT789320	hsa-miR-499a-5p	CLIP-seq
MIRT2173004	hsa-miR-500b	CLIP-seq
MIRT2173005	hsa-miR-501-5p	CLIP-seq
MIRT789327	hsa-miR-568	CLIP-seq
MIRT2173006	hsa-miR-575	CLIP-seq
MIRT789373	hsa-miR-619	CLIP-seq
MIRT2173007	hsa-miR-627	CLIP-seq
MIRT789336	hsa-miR-641	CLIP-seq
MIRT2173008	hsa-miR-668	CLIP-seq
MIRT789339	hsa-miR-889	CLIP-seq
MIRT2173009	hsa-miR-924	CLIP-seq
MIRT789341	hsa-miR-92a	CLIP-seq
MIRT789342	hsa-miR-92b	CLIP-seq
MIRT789375	hsa-miR-934	CLIP-seq
MIRT789344	hsa-miR-1258	CLIP-seq
MIRT789353	hsa-miR-3618	CLIP-seq
MIRT789354	hsa-miR-3655	CLIP-seq
MIRT789357	hsa-miR-4254	CLIP-seq
MIRT789364	hsa-miR-4653-3p	CLIP-seq
MIRT789373	hsa-miR-619	CLIP-seq
MIRT789375	hsa-miR-934	CLIP-seq
MIRT789230	hsa-miR-105	CLIP-seq
MIRT1932819	hsa-miR-145	CLIP-seq
MIRT789269	hsa-miR-3613-3p	CLIP-seq
MIRT789276	hsa-miR-3646	CLIP-seq
MIRT789279	hsa-miR-3671	CLIP-seq
MIRT2426371	hsa-miR-3923	CLIP-seq
MIRT2426372	hsa-miR-3925-3p	CLIP-seq
MIRT2426373	hsa-miR-4282	CLIP-seq
MIRT789311	hsa-miR-4760-3p	CLIP-seq
MIRT2426374	hsa-miR-4799-5p	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT2426375	hsa-miR-513a-3p	CLIP-seq
MIRT2426376	hsa-miR-515-5p	CLIP-seq
MIRT789333	hsa-miR-607	CLIP-seq
MIRT2426377	hsa-miR-628-3p	CLIP-seq
MIRT2426378	hsa-miR-766	CLIP-seq
MIRT2476209	hsa-miR-1184	CLIP-seq
MIRT789231	hsa-miR-1226	CLIP-seq
MIRT789232	hsa-miR-124	CLIP-seq
MIRT2476210	hsa-miR-1245b-3p	CLIP-seq
MIRT789235	hsa-miR-1290	CLIP-seq
MIRT2476211	hsa-miR-1298	CLIP-seq
MIRT2476212	hsa-miR-1299	CLIP-seq
MIRT2476213	hsa-miR-153	CLIP-seq
MIRT2476214	hsa-miR-1825	CLIP-seq
MIRT2476215	hsa-miR-1915	CLIP-seq
MIRT2476216	hsa-miR-199a-5p	CLIP-seq
MIRT2476217	hsa-miR-199b-5p	CLIP-seq
MIRT2476218	hsa-miR-203	CLIP-seq
MIRT2476219	hsa-miR-205	CLIP-seq
MIRT2476220	hsa-miR-218	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT2476221	hsa-miR-27a	CLIP-seq
MIRT2476222	hsa-miR-27b	CLIP-seq
MIRT2476223	hsa-miR-3159	CLIP-seq
MIRT1932820	hsa-miR-3189-3p	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT2476224	hsa-miR-361-3p	CLIP-seq
MIRT1932818	hsa-miR-3664-3p	CLIP-seq
MIRT2476225	hsa-miR-3912	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT2426372	hsa-miR-3925-3p	CLIP-seq
MIRT789282	hsa-miR-3942-3p	CLIP-seq
MIRT2476226	hsa-miR-3978	CLIP-seq
MIRT2476227	hsa-miR-4252	CLIP-seq
MIRT2476228	hsa-miR-4260	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT2476229	hsa-miR-4284	CLIP-seq
MIRT2476230	hsa-miR-4307	CLIP-seq
MIRT2476231	hsa-miR-4330	CLIP-seq
MIRT2476232	hsa-miR-4477a	CLIP-seq
MIRT2476233	hsa-miR-4485	CLIP-seq
MIRT2172998	hsa-miR-4522	CLIP-seq
MIRT2476234	hsa-miR-4639-3p	CLIP-seq
MIRT2476235	hsa-miR-4641	CLIP-seq
MIRT2476236	hsa-miR-4685-5p	CLIP-seq
MIRT1932822	hsa-miR-4686	CLIP-seq
MIRT2476237	hsa-miR-4715-3p	CLIP-seq
MIRT2476238	hsa-miR-4726-3p	CLIP-seq
MIRT2476239	hsa-miR-4744	CLIP-seq
MIRT2476240	hsa-miR-4749-3p	CLIP-seq
MIRT2476241	hsa-miR-4786-3p	CLIP-seq
MIRT2476242	hsa-miR-483-3p	CLIP-seq
MIRT2476243	hsa-miR-486-3p	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT2476244	hsa-miR-499-3p	CLIP-seq
MIRT2476245	hsa-miR-499a-3p	CLIP-seq
MIRT2476246	hsa-miR-502-5p	CLIP-seq
MIRT789321	hsa-miR-506	CLIP-seq
MIRT2476247	hsa-miR-513a-5p	CLIP-seq
MIRT789322	hsa-miR-513c	CLIP-seq
MIRT789323	hsa-miR-514b-5p	CLIP-seq
MIRT2476248	hsa-miR-520d-5p	CLIP-seq
MIRT2476249	hsa-miR-524-5p	CLIP-seq
MIRT789325	hsa-miR-548an	CLIP-seq
MIRT2476250	hsa-miR-579	CLIP-seq
MIRT2476251	hsa-miR-636	CLIP-seq
MIRT2173008	hsa-miR-668	CLIP-seq
MIRT2476252	hsa-miR-875-3p	CLIP-seq
MIRT2476209	hsa-miR-1184	CLIP-seq
MIRT2675133	hsa-miR-1200	CLIP-seq
MIRT789231	hsa-miR-1226	CLIP-seq
MIRT2476210	hsa-miR-1245b-3p	CLIP-seq
MIRT789236	hsa-miR-1292	CLIP-seq
MIRT2476211	hsa-miR-1298	CLIP-seq
MIRT2476212	hsa-miR-1299	CLIP-seq
MIRT2675134	hsa-miR-1470	CLIP-seq
MIRT2476213	hsa-miR-153	CLIP-seq
MIRT2476214	hsa-miR-1825	CLIP-seq
MIRT2476215	hsa-miR-1915	CLIP-seq
MIRT2476216	hsa-miR-199a-5p	CLIP-seq
MIRT2476217	hsa-miR-199b-5p	CLIP-seq
MIRT2476219	hsa-miR-205	CLIP-seq
MIRT2476220	hsa-miR-218	CLIP-seq
MIRT789256	hsa-miR-24	CLIP-seq
MIRT2476221	hsa-miR-27a	CLIP-seq
MIRT2476222	hsa-miR-27b	CLIP-seq
MIRT2675135	hsa-miR-3074-5p	CLIP-seq
MIRT789350	hsa-miR-3140-5p	CLIP-seq
MIRT2476223	hsa-miR-3159	CLIP-seq
MIRT1932820	hsa-miR-3189-3p	CLIP-seq
MIRT789266	hsa-miR-33a	CLIP-seq
MIRT789267	hsa-miR-33b	CLIP-seq
MIRT789271	hsa-miR-3617	CLIP-seq
MIRT2675136	hsa-miR-3688-3p	CLIP-seq
MIRT2476225	hsa-miR-3912	CLIP-seq
MIRT789280	hsa-miR-3913-3p	CLIP-seq
MIRT2426372	hsa-miR-3925-3p	CLIP-seq
MIRT2675137	hsa-miR-3974	CLIP-seq
MIRT2476226	hsa-miR-3978	CLIP-seq
MIRT2476228	hsa-miR-4260	CLIP-seq
MIRT789284	hsa-miR-4263	CLIP-seq
MIRT789285	hsa-miR-4267	CLIP-seq
MIRT2476229	hsa-miR-4284	CLIP-seq
MIRT2476230	hsa-miR-4307	CLIP-seq
MIRT2476231	hsa-miR-4330	CLIP-seq
MIRT2675138	hsa-miR-4438	CLIP-seq
MIRT2675139	hsa-miR-4446-5p	CLIP-seq
MIRT789294	hsa-miR-4471	CLIP-seq
MIRT2476232	hsa-miR-4477a	CLIP-seq
MIRT2476233	hsa-miR-4485	CLIP-seq
MIRT2675140	hsa-miR-4521	CLIP-seq
MIRT2172998	hsa-miR-4522	CLIP-seq
MIRT2675141	hsa-miR-4539	CLIP-seq
MIRT2476235	hsa-miR-4641	CLIP-seq
MIRT789300	hsa-miR-4646-5p	CLIP-seq
MIRT2675142	hsa-miR-4667-3p	CLIP-seq
MIRT2476236	hsa-miR-4685-5p	CLIP-seq
MIRT1932822	hsa-miR-4686	CLIP-seq
MIRT2476237	hsa-miR-4715-3p	CLIP-seq
MIRT2476238	hsa-miR-4726-3p	CLIP-seq
MIRT2675143	hsa-miR-4755-5p	CLIP-seq
MIRT2476241	hsa-miR-4786-3p	CLIP-seq
MIRT2476243	hsa-miR-486-3p	CLIP-seq
MIRT1932825	hsa-miR-495	CLIP-seq
MIRT2476244	hsa-miR-499-3p	CLIP-seq
MIRT2476245	hsa-miR-499a-3p	CLIP-seq
MIRT2476246	hsa-miR-502-5p	CLIP-seq
MIRT2675144	hsa-miR-505	CLIP-seq
MIRT2476247	hsa-miR-513a-5p	CLIP-seq
MIRT789322	hsa-miR-513c	CLIP-seq
MIRT789323	hsa-miR-514b-5p	CLIP-seq
MIRT2476248	hsa-miR-520d-5p	CLIP-seq
MIRT2476249	hsa-miR-524-5p	CLIP-seq
MIRT789328	hsa-miR-576-5p	CLIP-seq
MIRT2476250	hsa-miR-579	CLIP-seq
MIRT2476251	hsa-miR-636	CLIP-seq
MIRT789336	hsa-miR-641	CLIP-seq
MIRT2675145	hsa-miR-642a	CLIP-seq
MIRT2476252	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	NAS	15274632
GO:0005515	Function	Protein binding	IPI	12297508, 32296183, 32814053
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	15274632
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007220	Process	Notch receptor processing	IBA
GO:0007220	Process	Notch receptor processing	IDA	27608597
GO:0007220	Process	Notch receptor processing	NAS	10206645
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	IDA	12297508
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016485	Process	Protein processing	IDA	12297508
GO:0016485	Process	Protein processing	IDA	27608597
GO:0016485	Process	Protein processing	IEA
GO:0016485	Process	Protein processing	IGI	12763021
GO:0030133	Component	Transport vesicle	IDA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0030674	Function	Protein-macromolecule adaptor activity	IMP	12297508
GO:0031293	Process	Membrane protein intracellular domain proteolysis	ISS
GO:0034205	Process	Amyloid-beta formation	IDA	27608597
GO:0034205	Process	Amyloid-beta formation	IGI	12763021
GO:0042987	Process	Amyloid precursor protein catabolic process	IDA	27608597
GO:0042987	Process	Amyloid precursor protein catabolic process	IGI	12763021
GO:0042987	Process	Amyloid precursor protein catabolic process	ISS
GO:0061133	Function	Endopeptidase activator activity	IGI	12763021
GO:0061133	Function	Endopeptidase activator activity	IMP	12297508
GO:0070765	Component	Gamma-secretase complex	IBA
GO:0070765	Component	Gamma-secretase complex	IDA	12297508
GO:0070765	Component	Gamma-secretase complex	IEA
GO:0070765	Component	Gamma-secretase complex	IGI	12763021
GO:0070765	Component	Gamma-secretase complex	ISS

Other IDs

• MIM: 607630
• HGNC: 24080
• e!Ensembl: ENSG00000138613

Protein

• UniProt ID: Q8WW43
• Protein name: Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like)
• Protein function: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofact
• PDB: 8OQY , 8OQZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06105	Aph-1	2 → 238	Aph-1 protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12740439}.
• Sequence:

  MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
  DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
  GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
  CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
  CLLCQDKNFLLYNQRSR

• Sequence length: 257

Pathways

KEGG Pathway	Reactome Pathway
Notch signaling pathway	Nuclear signaling by ERBB4
Alzheimer disease	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	EPH-ephrin mediated repulsion of cells
	NOTCH3 Activation and Transmission of Signal to the Nucleus
	Noncanonical activation of NOTCH3
	Amyloid fiber formation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (10)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	30617256, 34493870, 35379992, 37198259, 37985413, 39129223, 39537608	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104, 39129223	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	33356394, 33462484, 39406924	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	34493870	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (13)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	33152005	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer Disease	Alzheimer disease	Pubtator	34732252	Stimulate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	30617256		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	27573188	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	33152005	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	LHGDN	18987747		★☆☆☆☆ Found in Text Mining only
Dementia, familial Danish	Dementia	BEFREE	26942869		★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	33152005	Associate	★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	GWASCAT_DG	27182965		★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	15721236		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	37512088	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	25808939		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	25808939	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NCSTN 10 shared pathwaysNotch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Amyloid fiber formation, NOTCH3 Activation and Transmission of Signal to the Nucleus, Nuclear signaling by ERBB4, EPH-ephrin mediated repulsion of cells, Regulated proteolysis of p75NTR, NRIF signals cell death from the nucleus, Noncanonical activation of NOTCH3 1 shared evidence sourceDisgenet (Alzheimer disease) Related via 10 shared pathways including Notch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants — evidence mostly Disgenet. APH1A 10 shared pathwaysNotch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Amyloid fiber formation, NOTCH3 Activation and Transmission of Signal to the Nucleus, Nuclear signaling by ERBB4, EPH-ephrin mediated repulsion of cells, Regulated proteolysis of p75NTR, NRIF signals cell death from the nucleus, Noncanonical activation of NOTCH3 Related via 10 shared pathways including Notch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants. PSENEN 10 shared pathwaysNotch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Amyloid fiber formation, NOTCH3 Activation and Transmission of Signal to the Nucleus, Nuclear signaling by ERBB4, EPH-ephrin mediated repulsion of cells, Regulated proteolysis of p75NTR, NRIF signals cell death from the nucleus, Noncanonical activation of NOTCH3 Related via 10 shared pathways including Notch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants. PSEN2 9 shared pathwaysNotch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, NOTCH3 Activation and Transmission of Signal to the Nucleus, Nuclear signaling by ERBB4, EPH-ephrin mediated repulsion of cells, Regulated proteolysis of p75NTR, NRIF signals cell death from the nucleus, Noncanonical activation of NOTCH3 1 shared evidence sourceDisgenet (Alzheimer disease) Related via 9 shared pathways including Notch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants — evidence mostly Disgenet. PSEN1 9 shared pathwaysNotch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, NOTCH3 Activation and Transmission of Signal to the Nucleus, Nuclear signaling by ERBB4, EPH-ephrin mediated repulsion of cells, Regulated proteolysis of p75NTR, NRIF signals cell death from the nucleus, Noncanonical activation of NOTCH3 1 shared evidence sourceDisgenet (Alzheimer disease) Related via 9 shared pathways including Notch signaling pathway, Constitutive Signaling by NOTCH1 PEST Domain Mutants — evidence mostly Disgenet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NCSTN	0	[]	10	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Amyloid fiber formation","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	1	["Disgenet (Alzheimer disease)"]
APH1A	0	[]	10	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Amyloid fiber formation","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	0	[]
PSENEN	0	[]	10	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Amyloid fiber formation","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	0	[]
PSEN2	0	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	1	["Disgenet (Alzheimer disease)"]
PSEN1	0	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","NOTCH3 Activation and Transmission of Signal to the Nucleus","Nuclear signaling by ERBB4","EPH-ephrin mediated repulsion of cells","Regulated proteolysis of p75NTR","NRIF signals cell death from the nucleus","Noncanonical activation of NOTCH3"]	1	["Disgenet (Alzheimer disease)"]

Diseases Linked via Similar Genes

Acne inversa Linked via 3 of 5 related genesNCSTN, PSENEN, PSEN1 Schizophrenia Linked via 2 of 5 related genesNCSTN, PSEN2 Jeune syndrome Linked via 2 of 5 related genesPSEN2, PSEN1 Dilated cardiomyopathy Linked via 2 of 5 related genesPSEN2, PSEN1 Pash syndrome Linked via 1 of 5 related genesNCSTN

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Acne inversa	3	["NCSTN","PSENEN","PSEN1"]
Schizophrenia	2	["NCSTN","PSEN2"]
Jeune syndrome	2	["PSEN2","PSEN1"]
Dilated cardiomyopathy	2	["PSEN2","PSEN1"]
Pash syndrome	1	["NCSTN"]