SLC8A2 (solute carrier family 8 member A2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6543
• Gene name: Solute carrier family 8 member A2
• Gene symbol: SLC8A2
• Synonyms (NCBI Gene): NCX2
• Chromosome: 19
• Chromosome location: 19q13.32

miRNA Show/Hide all (18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT736487	hsa-miR-206	Luciferase reporter assay, Western blotting, qRT-PCR	32075715
MIRT1368453	hsa-miR-1268	CLIP-seq
MIRT1368454	hsa-miR-1268b	CLIP-seq
MIRT1368455	hsa-miR-3190	CLIP-seq
MIRT1368456	hsa-miR-3681	CLIP-seq
MIRT1368457	hsa-miR-4488	CLIP-seq
MIRT1368458	hsa-miR-451b	CLIP-seq
MIRT1368459	hsa-miR-4697-5p	CLIP-seq
MIRT1368460	hsa-miR-4767	CLIP-seq
MIRT1368461	hsa-miR-585	CLIP-seq
MIRT2109510	hsa-miR-3663-3p	CLIP-seq
MIRT2109511	hsa-miR-4260	CLIP-seq
MIRT2109512	hsa-miR-4283	CLIP-seq
MIRT2109513	hsa-miR-4300	CLIP-seq
MIRT2109514	hsa-miR-4489	CLIP-seq
MIRT2109515	hsa-miR-4656	CLIP-seq
MIRT2109516	hsa-miR-4663	CLIP-seq
MIRT2109517	hsa-miR-920	CLIP-seq

Gene ontology (GO) Show/Hide all (86)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002931	Process	Response to ischemia	IEA
GO:0002931	Process	Response to ischemia	ISS
GO:0005432	Function	Calcium:sodium antiporter activity	IBA
GO:0005432	Function	Calcium:sodium antiporter activity	IEA
GO:0005432	Function	Calcium:sodium antiporter activity	ISS
GO:0005432	Function	Calcium:sodium antiporter activity	TAS
GO:0005516	Function	Calmodulin binding	IEA
GO:0005886	Component	Plasma membrane	IC
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006814	Process	Sodium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	ISS
GO:0006874	Process	Intracellular calcium ion homeostasis	ISS
GO:0007154	Process	Cell communication	IEA
GO:0007611	Process	Learning or memory	IEA
GO:0007611	Process	Learning or memory	ISS
GO:0007612	Process	Learning	IEA
GO:0007612	Process	Learning	ISS
GO:0007613	Process	Memory	IEA
GO:0007613	Process	Memory	ISS
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010468	Process	Regulation of gene expression	ISS
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0015081	Function	Sodium ion transmembrane transporter activity	ISS	8021246
GO:0015085	Function	Calcium ion transmembrane transporter activity	IEA
GO:0015085	Function	Calcium ion transmembrane transporter activity	ISS
GO:0015297	Function	Antiporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0035725	Process	Sodium ion transmembrane transport	IBA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0035725	Process	Sodium ion transmembrane transport	ISS	8021246
GO:0042383	Component	Sarcolemma	IBA
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0043197	Component	Dendritic spine	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0043679	Component	Axon terminus	ISS
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048172	Process	Regulation of short-term neuronal synaptic plasticity	IEA
GO:0048172	Process	Regulation of short-term neuronal synaptic plasticity	ISS
GO:0050808	Process	Synapse organization	IEA
GO:0050808	Process	Synapse organization	ISS
GO:0050890	Process	Cognition	IEA
GO:0050890	Process	Cognition	ISS
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IEA
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0060291	Process	Long-term synaptic potentiation	ISS
GO:0060291	Process	Long-term synaptic potentiation	ISS
GO:0070050	Process	Neuron cellular homeostasis	IEA
GO:0070050	Process	Neuron cellular homeostasis	ISS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	ISS	8021246
GO:0098703	Process	Calcium ion import across plasma membrane	IBA
GO:0098793	Component	Presynapse	IDA	21382638
GO:0098794	Component	Postsynapse	IBA
GO:0098815	Process	Modulation of excitatory postsynaptic potential	IEA
GO:0098815	Process	Modulation of excitatory postsynaptic potential	ISS
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0099608	Process	Regulation of action potential firing pattern	IEA
GO:0099608	Process	Regulation of action potential firing pattern	ISS
GO:0106056	Process	Regulation of calcineurin-mediated signaling	IEA
GO:0106056	Process	Regulation of calcineurin-mediated signaling	ISS
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653
GO:1902533	Process	Positive regulation of intracellular signal transduction	IEA
GO:1902533	Process	Positive regulation of intracellular signal transduction	ISS
GO:1903779	Process	Regulation of cardiac conduction	IEA
GO:1903779	Process	Regulation of cardiac conduction	TAS
GO:1905060	Function	Calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISS
GO:1990034	Process	Calcium ion export across plasma membrane	IEA
GO:1990034	Process	Calcium ion export across plasma membrane	ISS

Other IDs

• MIM: 601901
• HGNC: 11069
• e!Ensembl: ENSG00000118160

Protein

• UniProt ID: Q9UPR5
• Protein name: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2)
• Protein function: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01699	Na_Ca_ex	74 → 245	Sodium/calcium exchanger protein	Family
  PF01699	Na_Ca_ex	747 → 912	Sodium/calcium exchanger protein	Family
  PF16494	Na_Ca_ex_C	248 → 379	C-terminal extension of sodium/calcium exchanger domain	Family
  PF03160	Calx-beta	384 → 483	Calx-beta domain	Domain
  PF03160	Calx-beta	512 → 612	Calx-beta domain	Domain

• Sequence:

  MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP
  DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT
  VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
  IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
  VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP
  GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL
  MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
  GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
  RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
  VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
  YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE
  VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS
  CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
  DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
  WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
  GLWLLYILFASLEAYCHIRGF

• Sequence length: 921

Pathways

KEGG Pathway	Reactome Pathway
Calcium signaling pathway	Reduction of cytosolic Ca++ levels
cGMP-PKG signaling pathway	Sodium/Calcium exchangers
Cardiac muscle contraction	Ion homeostasis
Adrenergic signaling in cardiomyocytes
Apelin signaling pathway
Olfactory transduction
Endocrine and other factor-regulated calcium reabsorption
Protein digestion and absorption
Mineral absorption
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SLC8A1 14 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Apelin signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Protein digestion and absorption, Mineral absorption, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Ion homeostasis +2 more Related via 14 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. SLC8A3 14 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Apelin signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Protein digestion and absorption, Mineral absorption, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Ion homeostasis +2 more Related via 14 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. ATP2A1 9 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Ion homeostasis, Reduction of cytosolic Ca++ levels Related via 9 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. ATP2A2 9 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Ion homeostasis, Reduction of cytosolic Ca++ levels Related via 9 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. ATP2A3 9 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Ion homeostasis, Reduction of cytosolic Ca++ levels Related via 9 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SLC8A1	0	[]	14	["Calcium signaling pathway","cGMP-PKG signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Apelin signaling pathway","Endocrine and other factor-regulated calcium reabsorption","Protein digestion and absorption","Mineral absorption","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Ion homeostasis"]	0	[]
SLC8A3	0	[]	14	["Calcium signaling pathway","cGMP-PKG signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Apelin signaling pathway","Endocrine and other factor-regulated calcium reabsorption","Protein digestion and absorption","Mineral absorption","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Ion homeostasis"]	0	[]
ATP2A1	0	[]	9	["Calcium signaling pathway","cGMP-PKG signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Ion homeostasis","Reduction of cytosolic Ca++ levels"]	0	[]
ATP2A2	0	[]	9	["Calcium signaling pathway","cGMP-PKG signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Ion homeostasis","Reduction of cytosolic Ca++ levels"]	0	[]
ATP2A3	0	[]	9	["Calcium signaling pathway","cGMP-PKG signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Ion homeostasis","Reduction of cytosolic Ca++ levels"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 4 of 5 related genesSLC8A1, ATP2A1, ATP2A2, ATP2A3 Schizophrenia Linked via 3 of 5 related genesSLC8A1, SLC8A3, ATP2A2 Status epilepticus Linked via 3 of 5 related genesSLC8A1, SLC8A3, ATP2A2 Asthma Linked via 2 of 5 related genesSLC8A1, ATP2A1 Hypertension Linked via 2 of 5 related genesSLC8A1, ATP2A2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	4	["SLC8A1","ATP2A1","ATP2A2","ATP2A3"]
Schizophrenia	3	["SLC8A1","SLC8A3","ATP2A2"]
Status epilepticus	3	["SLC8A1","SLC8A3","ATP2A2"]
Asthma	2	["SLC8A1","ATP2A1"]
Hypertension	2	["SLC8A1","ATP2A2"]