Gene Gene information from NCBI Gene database.
Entrez ID 115361
Gene name Guanylate binding protein 4
Gene symbol GBP4
Synonyms (NCBI Gene)
Mpa2
Chromosome 1
Chromosome location 1p22.2
Summary Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
miRNA miRNA information provided by mirtarbase database.
861
miRTarBase ID miRNA Experiments Reference
MIRT049565 hsa-miR-92a-3p CLASH 23622248
MIRT717892 hsa-miR-6758-3p HITS-CLIP 19536157
MIRT717891 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT717890 hsa-miR-1236-3p HITS-CLIP 19536157
MIRT717889 hsa-miR-942-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000166 Function Nucleotide binding IEA
GO:0002376 Process Immune system process IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612466 20480 ENSG00000162654
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96PP9
Protein name Guanylate-binding protein 4 (EC 3.6.5.-) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4)
Protein function Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 tra
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02263 GBP 33 296 Guanylate-binding protein, N-terminal domain Domain
PF02841 GBP_C 298 594 Guanylate-binding protein, C-terminal domain Domain
Sequence
Sequence length 640
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  NOD-like receptor signaling pathway   Interferon gamma signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 37551111 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Medullary Medullary carcinoma Pubtator 26965581 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 32265897, 35213358 Associate
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Endometrial neoplasm Pubtator 33350104 Associate
★☆☆☆☆
Found in Text Mining only
Melanoma Melanoma Pubtator 34032721, 35135212, 37305390 Associate
★☆☆☆☆
Found in Text Mining only
Melanoma Cutaneous Malignant Melanoma Pubtator 32902917 Associate
★☆☆☆☆
Found in Text Mining only
Melanoma Cutaneous Malignant Melanoma Pubtator 34757537 Stimulate
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 27720713
★☆☆☆☆
Found in Text Mining only
Oropharyngeal Neoplasms Oropharyngeal neoplasm Pubtator 37175405 Associate
★☆☆☆☆
Found in Text Mining only