Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▲ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Brain infarction | Cerebral amyloid angiopathy |
12 genes
|
0.125 | 0.333 | 3.99e-20 | 7.65e-19 ✓ sig. | — | |
| Brain infarction | Lewy body disease |
12 genes
|
0.100 | 0.333 | 1.64e-18 | 2.90e-17 ✓ sig. | — | |
| Brain infarction | Proteinuria |
4 genes
|
0.053 | 0.111 | 2.64e-6 | 1.44e-5 ✓ sig. | — | |
| Brain infarction | Obstructive sleep apnea syndrome |
4 genes
|
0.035 | 0.111 | 3.68e-5 | 1.69e-4 ✓ sig. | — | |
| Brain infarction | Ventricular dysfunction |
3 genes
|
0.038 | 0.083 | 1.66e-4 | 5.01e-4 ✓ sig. | — | |
| Brain infarction | Hemophilia a |
2 genes
|
0.039 | 0.125 | 6.25e-4 | 1.24e-3 ✓ sig. | — | |
| Brain infarction | Cerebral arterial disease |
1 gene
Show details
ADGRE3(1)
|
0.027 | 1.000 | 2.34e-3 | 3.24e-3 ✓ sig. | — | |
| Brain infarction | immunodeficiency 122 |
1 gene
|
0.027 | 1.000 | 2.34e-3 | 3.24e-3 ✓ sig. | — | |
| Brain infarction | leukoencephalopathy with vanishing white matter 3 |
1 gene
|
0.027 | 1.000 | 2.34e-3 | 3.24e-3 ✓ sig. | — | |
| Brain infarction | neuroblastoma, susceptibility to, 3 |
1 gene
|
0.027 | 1.000 | 2.34e-3 | 3.24e-3 ✓ sig. | — | |
| Brain infarction | recombinase activating gene 1 deficiency |
1 gene
|
0.027 | 1.000 | 2.34e-3 | 3.24e-3 ✓ sig. | — | |
| Brain infarction | Trichomegaly |
1 gene
|
0.027 | 1.000 | 2.34e-3 | 3.24e-3 ✓ sig. | — | |
| Brain infarction | Cerebral artery occlusion |
1 gene
Show details
ADGRE3(1)
|
0.026 | 0.333 | 7.00e-3 | 8.28e-3 ✓ sig. | — |
0 selected
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Showing 13 of 13 matching pairs, sorted by significance (ascending). Click a column header to sort.