Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▼ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Kidney cancer | Very long chain acyl-coa dehydrogenase deficiency |
1 gene
|
0.012 | 0.250 | 2.09e-2 | 2.27e-2 ✓ sig. | — | |
| Kidney cancer | Vulto-van silfhout-de vries syndrome |
1 gene
|
0.012 | 0.500 | 1.05e-2 | 1.19e-2 ✓ sig. | — | |
| Camptodactyly | Kidney cancer |
1 gene
|
0.012 | 1.000 | 5.26e-3 | 6.42e-3 ✓ sig. | — | |
| fanconi anemia complementation group d2 | Kidney cancer |
1 gene
|
0.012 | 1.000 | 5.26e-3 | 6.42e-3 ✓ sig. | — | |
| hartnup disease | Kidney cancer |
1 gene
|
0.012 | 1.000 | 5.26e-3 | 6.42e-3 ✓ sig. | — | |
| Intellectual developmental disorder seizures cerebellar | Kidney cancer |
1 gene
|
0.012 | 1.000 | 5.26e-3 | 6.42e-3 ✓ sig. | — | |
| Isolated anhidrosis | Kidney cancer |
1 gene
|
0.012 | 1.000 | 5.26e-3 | 6.42e-3 ✓ sig. | — | |
| Kidney cancer | leukodystrophy, hypomyelinating, 25 |
1 gene
|
0.012 | 1.000 | 5.26e-3 | 6.42e-3 ✓ sig. | — | |
| Clonal hematopoiesis | Kidney cancer |
6 genes
|
0.045 | 0.107 | 4.62e-7 | 2.90e-6 ✓ sig. | — | |
| Kidney cancer | Lipoma |
4 genes
|
0.044 | 0.333 | 3.41e-7 | 2.18e-6 ✓ sig. | — | |
| Kidney cancer | Myeloproliferative disorder |
9 genes
|
0.071 | 0.170 | 7.18e-12 | 7.96e-11 ✓ sig. | — | |
| Kidney cancer | Uterine fibroid |
17 genes
|
0.046 | 0.210 | 3.08e-13 | 3.90e-12 ✓ sig. | — | |
| Clear cell renal cell carcinoma | Kidney cancer |
43 genes
|
0.457 | 0.782 | 4.35e-93 | 4.12e-91 ✓ sig. | — |
0 selected
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Showing 13 of 13 matching pairs, sorted by significance (descending). Click a column header to sort.