Subtype of: Salivary gland neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
salivary duct carcinoma	MONDO_0044915	MAPK1	Unknown	27103403	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MDM2	Unknown	34011559	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MED12	Unknown	27103403 28481359 27442865	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	26053092	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MPL	Unknown	27103403 28481359 27442865	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MRTFA	Unknown	27103403	Open Targets	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSH2	Unknown	27334835	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MTOR	Unknown	27103403 34011559	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	27103403 34011559	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	27103403 34011559	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	27103403	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYC	Unknown	28481359 27442865	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYD88	Unknown	27334835	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	27103403	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYH9	Unknown	34011559	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	27103403	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NBN	Unknown	27103403	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCOA2	Unknown	27103403	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	27103403 29420467 28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	27103403 34011559 28481359 27442865 27334835	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NIN	Unknown	27103403	Open Targets	—
		NOTCH1	Unknown	26053092	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NR4A3	Unknown	34011559	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NRG1	Unknown	27103403	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	27103403 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK2	Unknown	28481359 27442865	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	27103403	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	34011559	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUTM1	Unknown	27103403	Open Targets	—
		PBRM1	Unknown	27103403 34011559 28481359 27442865	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PCBP1	Unknown	34011559	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PDE4DIP	Unknown	27103403	Open Targets	—
		PDGFRA	Unknown	34011559	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	28481359 27442865	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PICALM	Unknown	27103403	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIK3CA	Unknown	32557577 32383006 34036229 24511546 31745978 27103403 23851329 27334835 37427101 23186780 26053092 29100278 34011559 28481359 27442865 34093024	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	27334835	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIM1	Unknown	27103403	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		POLE	Unknown	27103403 28481359 27442865	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PRDM1	Unknown	27103403 28481359 27442865	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	27103403	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRRX1	Unknown	27103403	Open Targets	—
		PTEN	Unknown	31745978 27103403 27334835 26053092 29100278 34011559 28481359 27442865	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	26053092	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	34011559	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		RABEP1	Unknown	27103403	Open Targets	Endocytosis TBC/RABGAPs
		RAD50	Unknown	34011559	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RANBP2	Unknown	27334835	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1GDS1	Unknown	27103403	Open Targets	—
		RB1	Unknown	26053092 27334835	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more

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Salivary duct carcinoma

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