Subtype of: Salivary gland neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
salivary duct carcinoma	MONDO_0044915	EBF1	Unknown	27103403 34011559	Open Targets	—
		ECT2L	Unknown	27103403	Open Targets	—
		EGFR	Unknown	20371674 27103403 27334835	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EP300	Unknown	27103403 34011559 28481359 27442865	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPHA7	Unknown	34011559	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	34011559	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	31745978 27103403 23933559 27334835 25343854 26053092 34011559 29420467 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	27103403 28481359 27442865 27334835	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	27103403 28481359 27442865	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERCC5	Unknown	34011559	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	28481359 27442865	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		FANCG	Unknown	34011559	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAT1	Unknown	27103403 28481359 27442865 27334835	Open Targets	—
		FAT3	Unknown	27103403	Open Targets	—
		FAT4	Unknown	27103403	Open Targets	Hippo signaling pathway - multiple species
		FBXW7	Unknown	27334835	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR1	Unknown	27103403	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	27103403 28481359 27442865	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR4	Unknown	34011559	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FLT4	Unknown	27103403	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FOXA1	Unknown	27103403 28481359	Open Targets	Estrogen-dependent gene expression
		FSTL3	Unknown	27103403	Open Targets	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		GPC5	Unknown	34011559	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GRIN2A	Unknown	29420467 28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		H3-3B	Unknown	28481359	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		HOXA11	Unknown	27103403	Open Targets	Transcriptional misregulation in cancer
		HRAS	Unknown	32383006 32557577 34036229 31745978 27103403 27334835 37427101 26053092 29100278 28481359 27442865 34093024	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	27103403	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	34011559	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IKZF1	Unknown	27103403 28481359 27442865	Open Targets	—
		IL7R	Unknown	28481359	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		JAK1	Unknown	34011559	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK3	Unknown	28481359	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KAT6A	Unknown	27103403	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	34011559	Open Targets	HATs acetylate histones
		KDM5A	Unknown	29420467 28481359	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	27103403 28481359	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	27103403	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KDSR	Unknown	27103403	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KLK2	Unknown	27103403	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	27103403	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	27103403 29420467 28481359 27442865	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	27103403 28481359 27442865	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LRP1B	Unknown	34011559	Open Targets	—
		MACC1	Unknown	27103403	Open Targets	—
		MAML2	Unknown	17437281 27103403	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	27334835	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K4	Unknown	27103403 28481359 27442865	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	34011559 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	27103403 28481359 27442865	Open Targets	MAPK signaling pathway

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Salivary duct carcinoma

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