Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	CRTC1	Unknown	33262464 31660073	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CRTC3	Unknown	22810696 33262464 31660073	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	29967250 28481359 33262464 25344691 31660073	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	28481359 29316426 25344691 25957691 31660073	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	22810696 29967250 30038269 33262464 27612425 29937994 26416732 31660073 30239619 25344691 17932254	Open Targets	—
		CTCF	Unknown	22810696 33262464 26416732 29316426 31660073 25344691 28481359	Open Targets	—
		CTNNA1	Unknown	22810696 25344691	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNA2	Unknown	22810696 33262464 27612425 29937994 26416732 31660073 30239619 25344691 24755471	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNNB1	Unknown	21602666 22810696 21901162 30038269 33262464 25617745 23009572 29937994 26416732 29316426 19679059 28465371 31660073 28978093 26134512 28548127 25344691 24755471 26764183 28481359	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CTNND1	Unknown	22810696 24755471 33262464 29937994 31660073	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		CTNND2	Unknown	22810696 30038269 33262464 29937994 31660073 30239619 25344691 24755471	Open Targets	Wnt signaling pathway
		CUL3	Unknown	29316426 28481359 29937994	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	26416732 26764183 33262464 25344691 31660073	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		CXCR4	Unknown	22810696 28481359	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		CYLD	Unknown	22810696 33262464 26764183 31660073	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		CYP2C8	Unknown	25344691	Open Targets	Arachidonic acid metabolism Linoleic acid metabolism Retinol metabolism +10 more
		CYSLTR2	Unknown	22810696 33262464 31660073	Open Targets	Calcium signaling pathway Neuroactive ligand-receptor interaction Glucagon signaling in metabolic regulation +6 more
		DAXX	Unknown	28481359 26416732 33262464 25344691 30239619	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCAF12L2	Unknown	22810696 33262464 25344691	Open Targets	—
		DCC	Unknown	22810696 29967250 30038269 33262464 29937994 26416732 31660073	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DCTN1	Unknown	22810696 24755471 26109429 33262464 31660073	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDB2	Unknown	22810696 33262464 31660073	Open Targets	Nucleotide excision repair p53 signaling pathway Ubiquitin mediated proteolysis +23 more
		DDIT3	Unknown	26109429 29937994	Open Targets	MAPK signaling pathway Protein processing in endoplasmic reticulum Apoptosis +9 more
		DDR2	Unknown	22810696 33262464 29316426 37262393 31660073 30239619 26764183 28481359	Open Targets	Non-integrin membrane-ECM interactions
		DDX10	Unknown	22810696 26416732 33262464 31660073	Open Targets	—
		DDX3X	Unknown	33262464 31660073	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DDX6	Unknown	27612425	Open Targets	RNA degradation mRNA decay by 5' to 3' exoribonuclease
		DEK	Unknown	26416732	Open Targets	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis
		DGCR8	Unknown	22810696 25344691	Open Targets	MicroRNA (miRNA) biogenesis
		DICER1	Unknown	33262464 29937994 26416732 31660073 26764183 28481359	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNAJB1	Unknown	28481359	Open Targets	Protein processing in endoplasmic reticulum Influenza A Regulation of HSF1-mediated heat shock response +4 more
		DNM2	Unknown	22810696 26109429 26416732 33262464	Open Targets	Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis +13 more
		DNMT3A	Unknown	30038269 33262464 29937994 26416732 29316426 28145097 25957691 31660073 25344691 24755471	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		DROSHA	Unknown	22810696 33262464 26416732 29316426 31660073 24755471	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	22810696 33262464 25957691 26109429 25344691 24755471	Open Targets	—
		ECT2L	Unknown	22810696 25344691	Open Targets	—
		EED	Unknown	33262464 28481359	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	27929064 24755471 33262464 21835826 26416732 29316426 27756406 31660073 28978093 26109429 25344691 26968814 25617745 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF1AX	Unknown	33262464 28481359	Open Targets	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits +3 more
		EIF3E	Unknown	25344691	Open Targets	Hepatitis C L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation +4 more
		EIF4A2	Unknown	29316426 26764183 28481359 31660073	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		ELF3	Unknown	22810696 25344691 31660073	Open Targets	Pre-NOTCH Transcription and Translation
		ELF4	Unknown	22810696 24755471 33262464	Open Targets	—
		ELL	Unknown	22810696 31660073	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		ELN	Unknown	33262464 29937994	Open Targets	Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix +2 more
		EML4	Unknown	30239619 33262464 31660073	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	22810696 33262464 28481359 29316426 28915719	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPAS1	Unknown	33262464 31660073	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	22810696 29967250 30038269 33262464 27612425 26416732 29316426 25344691 24755471 26764183 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	22810696 24943349 33262464 26416732 29316426 30239619 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more

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Rectum adenocarcinoma

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