Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	EPS15	Unknown	22810696 33262464 27612425 29937994 26416732 31660073	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	22810696 29967250 33262464 26416732 29316426 27247954 16397024 37262393 31660073 33774767 28978093 36212424 26134512 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	22810696 29967250 33262464 29937994 26416732 28120820 29316426 16998794 31660073 33774767 28978093 30239619 36212424 25344691 24755471 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	16187281 33262464 26416732 29316426 27756406 25957691 31660073 30239619 25344691 24755471 27155048 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	26416732 33262464 25344691 25957691 31660073	Open Targets	NF-kappa B signaling pathway
		ERCC2	Unknown	29316426 26416732 33262464 28481359 31660073	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC3	Unknown	26416732 28481359 31660073	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	22810696 29967250 29316426 25344691 24755471 26764183	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	22810696 30038269 33262464 29316426 31660073 28481359	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	28481359 33262464 25344691 17367471	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	33262464 29937994 29316426 26109429 26764183 28481359	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	25344691 31660073	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV1	Unknown	22810696 33262464 26416732 29316426 17367471 28481359	Open Targets	Transcriptional misregulation in cancer
		ETV5	Unknown	26109429 33262464 31660073	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV6	Unknown	26416732 25344691 28481359 29937994 31660073	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	26416732 33262464 31660073	Open Targets	Transcriptional misregulation in cancer
		EXT1	Unknown	33262464	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EXT2	Unknown	22810696 26416732 31660073	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EZH2	Unknown	26416732 29316426 28481359 31660073	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	26764183 33262464	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FADD	Unknown	33262464	Open Targets	Platinum drug resistance Apoptosis Apoptosis - multiple species +36 more
		FAM131B	Unknown	24755471 26109429 33262464 26416732	Open Targets	Signaling by BRAF and RAF fusions
		FAM135B	Unknown	22810696 24755471 33262464 29937994 31660073	Open Targets	—
		FAM47C	Unknown	22810696 29937994 26416732 25957691 30239619 25344691	Open Targets	—
		FANCA	Unknown	22810696 30038269 33262464 29937994 27612425 29316426 31660073 24755471 26764183 28481359	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	22810696 33262464 26416732 31660073 25344691 24755471	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCE	Unknown	25344691	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	22810696 33262464	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	22810696 30038269 33262464 25344691	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAS	Unknown	22810696 33262464 31660073	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	22810696 33262464 26416732 29316426 26109429 25344691 28481359	Open Targets	—
		FAT3	Unknown	22810696 30038269 33262464 24943349 29937994 26416732 31660073 26109429 30239619 24755471	Open Targets	—
		FAT4	Unknown	22810696 30038269 33262464 27612425 29937994 26416732 28145097 31660073 30239619 25344691 24755471 28551381	Open Targets	Hippo signaling pathway - multiple species
		FBLN2	Unknown	22810696 30239619 33262464 26764183 31660073	Open Targets	Cytoskeleton in muscle cells Molecules associated with elastic fibres
		FBXO11	Unknown	22810696 33262464 29937994 27612425 26416732 29316426 31660073 24755471 26764183 28481359	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	30038269 19420964 27612425 26416732 29316426 28120820 27121310 26134512 24755471 21726664 22810696 29967250 29069792 31660073 36212424 26109429 31400926 29937994 27756406 28465371 25344691 26764183 33262464 28978093 30239619 25617745 17932254 28481359 31226844	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCGR2B	Unknown	22810696 33262464	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FCRL4	Unknown	26416732 33262464 25344691 31660073	Open Targets	—
		FEN1	Unknown	33262464	Open Targets	DNA replication Base excision repair Non-homologous end-joining +6 more
		FGFR1	Unknown	22810696 33262464 26416732 29316426 31660073 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	22810696 33262464 26416732 29316426 31660073 25617745 26764183 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	30038269 33262464 27756406 31660073 30239619 24755471 26764183 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FGFR4	Unknown	33262464 29937994 26416732 29316426 31660073 24755471 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FH	Unknown	26416732 33262464 28481359	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FHIT	Unknown	26416732 33262464	Open Targets	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FIP1L1	Unknown	26764183 31660073	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FKBP9	Unknown	22810696	Open Targets	—
		FLCN	Unknown	26416732 29316426 28481359	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLI1	Unknown	22810696 24755471 33262464	Open Targets	Transcriptional misregulation in cancer
		FLNA	Unknown	22810696 33262464 31660073 25344691 24755471 26764183	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more

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Rectum adenocarcinoma

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