Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	FLT3	Unknown	22810696 26416732 28481359 30239619	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	33262464 29937994 26416732 29316426 31660073 30239619 25344691 28915719 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FNBP1	Unknown	22810696 24755471 33262464 25344691 31660073	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXA1	Unknown	22810696 33262464 28481359 31660073	Open Targets	Estrogen-dependent gene expression
		FOXL2	Unknown	26416732 28481359	Open Targets	SUMOylation of transcription factors
		FOXO1	Unknown	29316426 28481359	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		FOXO3	Unknown	30239619 26416732	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXO4	Unknown	22810696 25344691 31660073	Open Targets	Ras signaling pathway FoxO signaling pathway Shigellosis +7 more
		FOXP1	Unknown	33262464 27612425 29316426 31660073 26764183 28481359	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FOXR1	Unknown	33262464	Open Targets	—
		FSTL3	Unknown	31660073	Open Targets	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		FUBP1	Unknown	33262464 26416732 29316426 31660073 26109429 28481359	Open Targets	—
		FUS	Unknown	24755471 26109429 33262464 31660073	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GAS7	Unknown	22810696 26416732 33262464 25344691	Open Targets	—
		GATA1	Unknown	22810696 28481359	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	29967250 29316426 28481359	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA3	Unknown	29967250 30038269 33262464 29316426 31660073 26764183 28481359	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	22810696 30038269 33262464 26416732 25344691 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	26416732 33262464 29937994	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNA11	Unknown	28481359 26764183 27756406 25344691 31660073	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAQ	Unknown	29967250 26416732 29316426 27756406 28481359	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	29967250 30038269 33262464 24470207 27612425 29937994 26416732 29316426 31660073 30239619 25344691 28481359	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	22810696	Open Targets	Intra-Golgi traffic
		GOPC	Unknown	25344691	Open Targets	RHO GTPases regulate CFTR trafficking
		GPC3	Unknown	22810696 26416732 33262464	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	22810696 24755471 26416732 30239619 29937994	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	22810696 31660073	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	22810696 29967250 30038269 33262464 26416732 29316426 31660073 26109429 30239619 26764183 28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	22810696 31660073 33262464 26764183 27612425	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	22810696 33262464 29316426 31660073 30239619 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		GTF2I	Unknown	29967250 33262464 26416732 25957691 31660073 26109429	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		H3-3A	Unknown	22810696	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3-3B	Unknown	29967250 33262464	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3C2	Unknown	26416732 26764183	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HERPUD1	Unknown	31660073	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HEY1	Unknown	22810696 31660073	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		HGF	Unknown	33262464 26416732 29316426 31660073 25344691 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	24755471 31660073	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HIP1	Unknown	26764183 33262464 25344691 31660073	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLA-A	Unknown	22810696 29316426 25957691 31660073 30239619 28481359	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HLF	Unknown	22810696 26416732 31660073	Open Targets	—
		HMGA2	Unknown	33262464 25957691	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HNF1A	Unknown	22810696 29316426 19503063 25344691 24755471 28481359	Open Targets	Maturity onset diabetes of the young
		HNRNPA2B1	Unknown	24755471 26416732	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HOOK3	Unknown	22810696 30239619	Open Targets	Motor proteins
		HOXA13	Unknown	31660073	Open Targets	—
		HOXC11	Unknown	30239619	Open Targets	—
		HOXC13	Unknown	22810696 25344691	Open Targets	—
		HOXD11	Unknown	25344691	Open Targets	—
		HOXD13	Unknown	33262464	Open Targets	—

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Rectum adenocarcinoma

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