Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	BARD1	Unknown	22810696 29967250 33262464 29937994 29316426 28481359	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BAX	Unknown	20979647 33262464 29937994 20565851 19503063 24755471 26764183	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more
		BAZ1A	Unknown	33262464 31660073	Open Targets	ATP-dependent chromatin remodeling
		BCL10	Unknown	26416732	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	26416732 33262464 25344691 31660073	Open Targets	—
		BCL11B	Unknown	31660073 26764183 25344691 33262464	Open Targets	Transcriptional misregulation in cancer
		BCL2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL2L12	Unknown	22810696	Open Targets	—
		BCL3	Unknown	30038269 31660073	Open Targets	C-type lectin receptor signaling pathway TNF signaling pathway
		BCL6	Unknown	24755471 33262464 30038269 31660073	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL7A	Unknown	33262464	Open Targets	ATP-dependent chromatin remodeling
		BCL9	Unknown	22810696 30038269 33262464 29937994 26416732 31660073 30239619 26764183 17932254	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCL9L	Unknown	22810696 30038269 33262464 27612425 26416732 25957691 31660073 25344691 24755471	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	22810696 30038269 33262464 27612425 31660073 30239619 25344691	Open Targets	—
		BCOR	Unknown	22810696 29967250 33262464 29316426 31660073 25344691 28481359	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	22810696 33262464 27612425 26416732 31660073 25344691 26764183	Open Targets	Polycomb repressive complex
		BCR	Unknown	30038269 26416732 29937994	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC3	Unknown	22810696 33262464 28481359	Open Targets	Platinum drug resistance NF-kappa B signaling pathway Ubiquitin mediated proteolysis +23 more
		BIRC6	Unknown	22810696 30038269 29937994 26416732 31660073 25344691	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	22810696 33262464 28481359 29316426 31660073	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BMP5	Unknown	29937994	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BMPR1A	Unknown	29967250 33262464 28481359	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	23226389 30038269 21289333 27612425 21704278 23534748 26416732 29316426 20496269 27121310 14688025 26134512 24759670 23125007 24367680 23469219 24755471 24764675 22810696 28481359 22586484 21103049 20635392 23660947 28145097 15790700 25636897 21910869 21901162 21285991 25418895 19913317 29937994 19637313 27756406 19669908 19358278 25344691 20664940 19001320 33262464 24470207 20824716 18339680 28978093 28548127 15702478 22427190 23569465 27239120 22001634 21646616 19903786	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	24755471 26416732 33262464 28481359 29937994	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	22810696 29967250 33262464 27612425 29937994 26416732 29316426 28465371 31660073 28481359	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	33262464	Open Targets	—
		BRD4	Unknown	22810696 26416732 29316426 28481359 31660073	Open Targets	—
		BRIP1	Unknown	26416732 29316426 28481359 29937994	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
		BTG1	Unknown	33262464	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BTK	Unknown	22810696 28481359 31660073	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Platelet activation +17 more
		BUB1B	Unknown	22810696 30038269 33262464 29967250	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CACNA1D	Unknown	33262464 29937994 31660073 25344691 24755471 26764183	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CALR	Unknown	29316426 33262464 28481359	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CAMTA1	Unknown	24755471 26109429 33262464 26764183 31660073	Open Targets	—
		CANT1	Unknown	24755471 33262464 31660073	Open Targets	Purine metabolism Pyrimidine metabolism Metabolic pathways +2 more
		CARD11	Unknown	29967250 30038269 33262464 26416732 28120820 31660073 26109429 24755471 28481359	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CARS1	Unknown	33262464 31660073	Open Targets	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		CASP3	Unknown	31660073	Open Targets	Platinum drug resistance MAPK signaling pathway p53 signaling pathway +53 more
		CASP8	Unknown	33262464 29316426 31660073 28978093 12949717 26764183 28481359	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CASP9	Unknown	33262464	Open Targets	Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway +39 more
		CBFA2T3	Unknown	31660073 26416732 33262464 25344691 29937994	Open Targets	—
		CBFB	Unknown	33262464	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBL	Unknown	24755471 30239619 29316426 28481359 33262464	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CBLB	Unknown	26416732 33262464 29937994 31660073	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CBLC	Unknown	25344691	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CCDC6	Unknown	31660073	Open Targets	Pathways in cancer Thyroid cancer
		CCNB1IP1	Unknown	31660073	Open Targets	—
		CCNC	Unknown	33262464 31660073	Open Targets	PPARA activates gene expression Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription +3 more
		CCND1	Unknown	29316426 33262464 28481359 31660073	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCND3	Unknown	28481359 25344691	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more

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Rectum adenocarcinoma

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