Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
PARKINSON DISEASE	C0030567 MESH:D010300 MONDO_0005180 MONDO:0005180	NDUFV2	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +12 more
		NECTIN2	Unknown	25475535 39080267	CTD, Disgenet, GWAS catalog	Virion - Herpesvirus Cell adhesion molecules Adherens junction +4 more
		NGEF	Unknown	32201043	GWAS catalog	Axon guidance NRAGE signals death through JNK Rho GTPase cycle +2 more
		NGF	Unknown	19276553	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +18 more
		NKAIN2	Unknown	33987465	GWAS catalog	—
		NKAIN3	Unknown	33958783	GWAS catalog	—
		NOD2	Unknown	31701892 38155330	GWAS catalog	NOD-like receptor signaling pathway TNF signaling pathway Tuberculosis +7 more
		NOL4	Unknown	38155330	GWAS catalog	—
		NOS1	Unknown	26383258	CTD, Disgenet	Arginine biosynthesis Arginine and proline metabolism Metabolic pathways +18 more
		NQO1	Unknown	17188257	CTD, Disgenet	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors +5 more
		NQO2	Unknown	—	Disgenet	Phase I - Functionalization of compounds
		NR1D2	Unknown	33111402	GWAS catalog	Circadian rhythm Nuclear Receptor transcription pathway
		NR4A2	Unknown	—	Disgenet	Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action Nuclear Receptor transcription pathway
		NSF	Unknown	19915575 20711177 21812969 31701892 38155330	GWAS catalog	Synaptic vesicle cycle GABAergic synapse Vasopressin-regulated water reabsorption +6 more
		NTRK1	Unknown	37842648	GWAS catalog	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	33111402	GWAS catalog	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NUCKS1	Unknown	19915575 24842889 25064009 27182965 28892059 31701892 32201043 36759515 37805635 38155330	GWAS catalog	—
		NXPE2	Unknown	33111402	GWAS catalog	—
		OCA2	Unknown	19772629	GWAS catalog	Melanin biosynthesis
		ODAPH	Unknown	22658654	GWAS catalog	—
		P2RX5	Unknown	34064523	GWAS catalog	Calcium signaling pathway Neuroactive ligand-receptor interaction Elevation of cytosolic Ca2+ levels +1 more
		PABPN1L	Unknown	25663231	GWAS catalog	mRNA surveillance pathway Influenza A
		PAM	Unknown	28892059 31701892	GWAS catalog	—
		PARD3	Unknown	33111402	GWAS catalog	Rap1 signaling pathway Chemokine signaling pathway Endocytosis +7 more
		PARK7	Unknown	12446870 14607841 15525661 15784737 17010972 20423725 20800516 22043175 22898350 23037695 23792957 25149416 16632486 18436956 26972524 28502045 30928208	CTD, ClinGen, Disgenet, GWAS catalog	Parkinson disease Pathways of neurodegeneration - multiple diseases SUMOylation of transcription cofactors +1 more
		PARP1	Unknown	—	Disgenet	Base excision repair NF-kappa B signaling pathway Apoptosis +9 more
		PARP9	Unknown	32201043 38155330	GWAS catalog	Nicotinamide salvaging
		PAX7	Unknown	20070850	GWAS catalog	Transcriptional misregulation in cancer
		PBXIP1	Unknown	37842648	GWAS catalog	—
		PCGF3	Unknown	38155330	GWAS catalog	Polycomb repressive complex Signaling pathways regulating pluripotency of stem cells
		PDLIM2	Unknown	38155330	GWAS catalog	Cytoskeleton in muscle cells
		PDZD2	Unknown	39503264	GWAS catalog	—
		PGS1	Unknown	38155330	GWAS catalog	Glycerophospholipid metabolism Metabolic pathways
		PHACTR2	Unknown	—	Disgenet	Platelet degranulation
		PI15	Unknown	33111402	GWAS catalog	—
		PIGL	Unknown	38155330	GWAS catalog	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)
		PIK3CA	Unknown	38155330	GWAS catalog	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PINK1	Unknown	15087508 15349870 15349871 15596610 16401616 16672980 16938835 17010972 21366594 22043175 24374061 25149416 30734931 20126261 20153330 28438176	CTD, ClinGen, Disgenet	Mitophagy - animal Parkinson disease Amyotrophic lateral sclerosis +2 more
		PITPNM2	Unknown	38155330	GWAS catalog	Synthesis of PI
		PJA1	Unknown	33583074	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		PKP2	Unknown	38155330	GWAS catalog	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Keratinization +1 more
		PLA2G6	Unknown	—	Disgenet	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +12 more
		PLEKHM1	Unknown	20070850	GWAS catalog	Autophagy - animal Salmonella infection
		PLPP4	Unknown	34776419	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Role of phospholipids in phagocytosis
		PLPPR1	Unknown	30338293	GWAS catalog	Lysosphingolipid and LPA receptors
		PMF1-BGLAP	Unknown	37842648	GWAS catalog	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion +3 more
		PMVK	Unknown	24842889 31701892 37842648 38155330	GWAS catalog	Terpenoid backbone biosynthesis Metabolic pathways Peroxisome +2 more
		POLG	Unknown	—	Disgenet	Base excision repair
		POLR2A	Unknown	33958783	GWAS catalog	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		POLR3B	Unknown	21084426	GWAS catalog	RNA polymerase Cytosolic DNA-sensing pathway Cytosolic sensors of pathogen-associated DNA +3 more
PARKINSON DISEASE 14, AUTOSOMAL RECESSIVE	612953 C2751842 OMIM:612953	PLA2G6	Unknown	—	CTD, Disgenet, HPO	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +12 more
PARKINSON DISEASE 20, EARLY-ONSET	C3809824	POLG	Unknown	—	Disgenet	Base excision repair
PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET	C1853833 605909 MESH:C565276	PARK7	Unknown	—	Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases SUMOylation of transcription cofactors +1 more
PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET	C1853833 605909 MESH:C565276	PINK1	Unknown	19048950 21421046 24475098 27003823	CTD, Disgenet, HPO	Mitophagy - animal Parkinson disease Amyotrophic lateral sclerosis +2 more
PARKINSON DISEASE 7, AUTOSOMAL RECESSIVE EARLY-ONSET	606324 C1853445 MESH:C565238	PARK7	Unknown	28348719	CTD, Disgenet, HPO	Parkinson disease Pathways of neurodegeneration - multiple diseases SUMOylation of transcription cofactors +1 more
PARKINSON DISEASE, MITOCHONDRIAL	C1838867	NDUFV2	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +12 more
PARKINSONIAN DISORDERS	C0242422 MESH:D020734	NGF	Unknown	19694610	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +18 more
		PARK7	Unknown	23046578 26558463	CTD, Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases SUMOylation of transcription cofactors +1 more
		PARP1	Unknown	17640816	CTD, Disgenet	Base excision repair NF-kappa B signaling pathway Apoptosis +9 more
		PINK1	Unknown	11254447 15349871 23046578 24441527 24792327 26558463	CTD, Disgenet	Mitophagy - animal Parkinson disease Amyotrophic lateral sclerosis +2 more
		POLG	Unknown	17923349	CTD, Disgenet	Base excision repair
YOUNG ONSET PARKINSON DISEASE	C4275179	PARK7	Unknown	33559681	Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases SUMOylation of transcription cofactors +1 more
YOUNG ONSET PARKINSON DISEASE	C4275179	PINK1	Unknown	—	Disgenet	Mitophagy - animal Parkinson disease Amyotrophic lateral sclerosis +2 more
YOUNG-ONSET PARKINSON DISEASE	2828 MONDO:0017279	PINK1	Unknown	26528954	CTD, Orphanet, ClinGen	Mitophagy - animal Parkinson disease Amyotrophic lateral sclerosis +2 more

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Parkinson disease

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