Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
AUTOSOMAL DOMINANT LATE ONSET PARKINSON DISEASE	C4274355	ADH1C	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism +8 more
		ATXN2	Unknown	—	Disgenet	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		ATXN3	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases +2 more
		DNAJC13	Unknown	—	Disgenet	Neutrophil degranulation
		EIF4G1	Unknown	—	Disgenet	Viral myocarditis ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression +9 more
		GBA1	Unknown	—	Disgenet	—
		GSTP1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +11 more
		HLA-DRA	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		LRRK2	Unknown	—	Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases PTK6 promotes HIF1A stabilization
		MAPT	Unknown	—	Disgenet	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		PSAP	Unknown	—	Disgenet	Sphingolipid metabolism Lysosome Platelet degranulation +4 more
		SNCA	Unknown	—	Disgenet	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
		TBP	Unknown	—	Disgenet	Basal transcription factors Huntington disease Spinocerebellar ataxia +18 more
		VPS35	Unknown	—	Disgenet	Endocytosis WNT ligand biogenesis and trafficking
IDIOPATHIC PARKINSONISM OR PARKINSONS DISEASE	C0865475	DNAJC6	Unknown	—	Disgenet	Endocytosis Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis +1 more
		SNCA	Unknown	—	Disgenet	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
		VPS13C	Unknown	—	Disgenet	—
PARKINSON DISEASE	C0030567 MONDO_0005180 MESH:D010300 MONDO:0005180	A2M	Unknown	—	Disgenet	Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation +3 more
		AACS	Unknown	33111402	GWAS catalog	Valine, leucine and isoleucine degradation Butanoate metabolism Metabolic pathways +1 more
		AAK1	Unknown	19772629	GWAS catalog	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		ABCB1	Unknown	20558393	CTD, Disgenet	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ADARB2	Unknown	25475535	CTD, Disgenet	—
		ADD1	Unknown	38155330	GWAS catalog	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
		AGAP1	Unknown	28892059	GWAS catalog	Endocytosis
		AIF1	Unknown	19276553	CTD, Disgenet	—
		AKT1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALCAM	Unknown	39503264	GWAS catalog	Cell adhesion molecules
		ALDH2	Unknown	24491970	CTD, Disgenet	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	37842648	GWAS catalog	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMZ1	Unknown	37842648	GWAS catalog	—
		ANG	Unknown	—	Disgenet	Amyotrophic lateral sclerosis Adherens junctions interactions
		ANO2	Unknown	33111402	GWAS catalog	Olfactory transduction Stimuli-sensing channels
		ANO5	Unknown	22451204	GWAS catalog	Efferocytosis Stimuli-sensing channels
		APOE	Unknown	30957308 33111402 36348503 39503264	GWAS catalog	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
		AQP10	Unknown	33111402	GWAS catalog	Passive transport by Aquaporins
		AREL1	Unknown	38155330	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		ARHGAP27	Unknown	31701892 38155330	GWAS catalog	Rho GTPase cycle
		ARHGEF2	Unknown	37842648	GWAS catalog	Tight junction Pathogenic Escherichia coli infection Shigellosis +4 more
		ASCL4	Unknown	37805635	GWAS catalog	—
		ASH1L	Unknown	34064523 37842648 38155330	GWAS catalog	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		ASXL3	Unknown	31701892 38155330	GWAS catalog	Polycomb repressive complex
		ATF6	Unknown	19772629	GWAS catalog	Protein processing in endoplasmic reticulum Alzheimer disease Parkinson disease +5 more
		ATM	Unknown	—	Disgenet	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP13A2	Unknown	23628791 25149416	CTD, Disgenet	Ion transport by P-type ATPases
		ATP6	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +10 more
		BAG3	Unknown	31701892 32201043	GWAS catalog	Regulation of HSF1-mediated heat shock response
		BAG5	Unknown	28348719	CTD, Disgenet	Regulation of HSF1-mediated heat shock response
		BBS9	Unknown	36348503	GWAS catalog	BBSome-mediated cargo-targeting to cilium
		BCKDK	Unknown	25064009 28892059	GWAS catalog	Branched-chain amino acid catabolism
		BCL9	Unknown	40465716	GWAS catalog	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BDNF	Unknown	19276553	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		DNAJC13	Unknown	—	Disgenet	Neutrophil degranulation
		DNAJC6	Unknown	—	Disgenet	Endocytosis Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis +1 more
		GSTP1	Unknown	17190945 23721876	CTD, Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +11 more
		HLA-DRA	Unknown	20711177 22451204 24511991	CTD, Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		MAPT	Unknown	19915575 20711177 21044948 25064009 28892059 38155330	CTD, Disgenet, GWAS catalog	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		SNCA	Unknown	11535288 12151787 12732244 12885775 14535945 15099020 17131421 17690948 18322262 18353766 18841091 19915575 19915576 20664293 20711177 21245015 21892157 22043175 22110584 22166454 22185909 22355530 24509835 24833599 25064009 25106	CTD, ClinGen, Disgenet, GWAS catalog, GenCC	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
		VPS35	Unknown	17405131 21763482 21763483 22517097 22991136 23125461 24152121 25149416 25288323 28985717 30155515 30842285 33032646 33142012 33347683 33745227	CTD, ClinGen, Disgenet	Endocytosis WNT ligand biogenesis and trafficking
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT	168601 C1868595 OMIM:168601	SNCA	Unknown	—	CTD, Disgenet, HPO	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
PARKINSON DISEASE 18, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO	MONDO:0013653 OMIM:614251	EIF4G1	Unknown	—	CTD, ClinVar, GenCC	Viral myocarditis ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression +9 more
PARKINSON DISEASE 19A, JUVENILE-ONSET	615528 C3809811 OMIM:615528	DNAJC6	Unknown	—	CTD, Disgenet, HPO	Endocytosis Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis +1 more
PARKINSON DISEASE 21	C4225353	DNAJC13	Unknown	24218364 33505021 17620502 12847165 12730996 12629236 19966284 29311685 25393719 16148263 31658403 19846850 27270108 12761037 31261387 19286695 28193887 18332251	Disgenet	Neutrophil degranulation
PARKINSON DISEASE 23, AUTOSOMAL RECESSIVE EARLY-ONSET	616840 OMIM:616840	VPS13C	Unknown	—	CTD, HPO	—
PARKINSON DISEASE 23, AUTOSOMAL RECESSIVE, EARLY ONSET	C4225186	VPS13C	Unknown	—	Disgenet	—
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT	605543	SNCA	Unknown	—	HPO	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY	C1854182 MESH:C565324	SNCA	Unknown	—	CTD, Disgenet	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
PARKINSON DISEASE 8, AUTOSOMAL DOMINANT	C1846862 OMIM:607060	LRRK2	Unknown	—	CTD, Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases PTK6 promotes HIF1A stabilization
PARKINSON DISEASE, MITOCHONDRIAL	C1838867	ADH1C	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism +8 more
PARKINSONIAN DISORDERS	C0242422 MESH:D020734	ATP13A2	Unknown	23046578	CTD, Disgenet	Ion transport by P-type ATPases
		BDNF	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		GBA1	Unknown	25881142	CTD, Disgenet, ClinGen	—
		LRRK2	Unknown	23046578 25017139 26558463	CTD, Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases PTK6 promotes HIF1A stabilization
		MAPT	Unknown	10802785 19458322	CTD, Disgenet	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		SNCA	Unknown	20464527 22319455 23046578 23295396 26075822 26558463 26687234 27026137 27324791 38016618	CTD, Disgenet	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
YOUNG ONSET PARKINSON DISEASE	C4275179	DNAJC6	Unknown	—	Disgenet	Endocytosis Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis +1 more
		LRRK2	Unknown	—	Disgenet	Parkinson disease Pathways of neurodegeneration - multiple diseases PTK6 promotes HIF1A stabilization
		SNCA	Unknown	—	Disgenet	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
		VPS13C	Unknown	—	Disgenet	—
YOUNG-ONSET PARKINSON DISEASE	2828 MONDO:0017279	DNAJC6	Unknown	—	CTD, Orphanet	Endocytosis Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis +1 more
YOUNG-ONSET PARKINSON DISEASE	2828 MONDO:0017279	SNCA	Unknown	22166458	Orphanet, ClinGen	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more

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Parkinson disease

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