Myocardial ischemia

Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling PI3K-Akt signaling pathway JAK-STAT signaling pathway Growth hormone synthesis, secretion and action Prolactin receptor signaling Growth hormone receptor signaling +5 more

Gap junction assembly

Glycerolipid metabolism Metabolic pathways PPAR signaling pathway Triglyceride biosynthesis +1 more

MAPK signaling pathway cGMP-PKG signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Vascular smooth muscle contraction Long-term depression Regulation of actin cytoskeleton Parathyroid hormone synthesis, secretion and action Pathogenic Escherichia coli infection Human cytomegalovirus infection Pathways in cancer G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) +11 more

Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Taste transduction Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +45 more

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism +7 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation Heme degradation +11 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Prostate cancer Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation +11 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Long-term depression Oxytocin signaling pathway Renin secretion Salivary secretion +8 more

Starch and sucrose metabolism Metabolic pathways Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1) Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis) +6 more

Fatty acid elongation Fatty acid degradation Valine, leucine and isoleucine degradation Lysine degradation Tryptophan metabolism beta-Alanine metabolism Propanoate metabolism Butanoate metabolism Metabolic pathways Fatty acid metabolism Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA +15 more

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway +3 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Focal adhesion Malaria Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Melanoma Non-small cell lung cancer Hepatocellular carcinoma Gastric cancer Platelet degranulation PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 +29 more

Glycolysis / Gluconeogenesis Fructose and mannose metabolism Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways Carbon metabolism Biosynthesis of nucleotide sugars HIF-1 signaling pathway Insulin signaling pathway Type II diabetes mellitus Carbohydrate digestion and absorption Shigellosis Central carbon metabolism in cancer Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis +14 more

Glycolysis / Gluconeogenesis Fructose and mannose metabolism Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways Carbon metabolism Biosynthesis of nucleotide sugars HIF-1 signaling pathway Insulin signaling pathway Type II diabetes mellitus Carbohydrate digestion and absorption Shigellosis Central carbon metabolism in cancer Glycolysis +13 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

Base excision repair Autophagy - animal Necroptosis Neutrophil extracellular trap formation Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

Terpenoid backbone biosynthesis Metabolic pathways AMPK signaling pathway Bile secretion Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination +5 more

Valine, leucine and isoleucine degradation Butanoate metabolism Terpenoid backbone biosynthesis Metabolic pathways PPAR signaling pathway PPARA activates gene expression Synthesis of Ketone Bodies +4 more

Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway Ferroptosis Mineral absorption Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane +11 more

Maturity onset diabetes of the young

Influenza A mRNA Splicing - Major Pathway

Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum Endocytosis Longevity regulating pathway - multiple species Antigen processing and presentation Estrogen signaling pathway Prion disease Legionellosis Toxoplasmosis Measles Lipid and atherosclerosis Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation +16 more

Antigen processing and presentation Lipid and atherosclerosis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase +2 more

RNA degradation Tuberculosis Regulation of HSF1-mediated heat shock response Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +1 more

RNA degradation Type I diabetes mellitus Legionellosis Tuberculosis Lipid and atherosclerosis Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation +4 more

NF-kappa B signaling pathway Cell adhesion molecules Natural killer cell mediated cytotoxicity TNF signaling pathway Leukocyte transendothelial migration AGE-RAGE signaling pathway in diabetic complications African trypanosomiasis Malaria Staphylococcus aureus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Rheumatoid arthritis Viral myocarditis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +19 more

Rap1 signaling pathway TGF-beta signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Oncogene Induced Senescence NGF-stimulated transcription +3 more

TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis Osteoclast differentiation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Interferon gamma signaling Regulation of IFNG signaling +17 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway HIF-1 signaling pathway FoxO signaling pathway Hormone signaling Oocyte meiosis p53 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Focal adhesion Signaling pathways regulating pluripotency of stem cells Long-term depression Inflammatory mediator regulation of TRP channels Ovarian steroidogenesis Progesterone-mediated oocyte maturation Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer Glioma Prostate cancer Melanoma Breast cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin +35 more

MicroRNAs in cancer Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MAPK6/MAPK4 signaling

p53 signaling pathway Cellular senescence Growth hormone synthesis, secretion and action Transcriptional misregulation in cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation +4 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway Efferocytosis C-type lectin receptor signaling pathway JAK-STAT signaling pathway T cell receptor signaling pathway Intestinal immune network for IgA production Pertussis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Staphylococcus aureus infection Tuberculosis Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Allograft rejection Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis +25 more

MAPK signaling pathway Cytokine-cytokine receptor interaction Necroptosis Cellular senescence Osteoclast differentiation Hematopoietic cell lineage Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pertussis Leishmaniasis Tuberculosis Measles Influenza A Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Fluid shear stress and atherosclerosis Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +24 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Inflammatory mediator regulation of TRP channels Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Measles Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Lipid and atherosclerosis Fluid shear stress and atherosclerosis Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +47 more

Cytokine-cytokine receptor interaction PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling +1 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

EGFR tyrosine kinase inhibitor resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Th17 cell differentiation Non-alcoholic fatty liver disease Human cytomegalovirus infection Coronavirus disease - COVID-19 Pathways in cancer Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling +13 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th17 cell differentiation Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling +12 more

MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway Neurotrophin signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling IRAK1 recruits IKK complex TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane +33 more

C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway Pertussis Human papillomavirus infection Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production +5 more

cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Neurotrophin signaling pathway Insulin signaling pathway Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Alzheimer disease MicroRNAs in cancer Diabetic cardiomyopathy PI3K Cascade IRS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation +30 more