Myocardial ischemia

Butyrophilin (BTN) family interactions

Efferocytosis Complement and coagulation cascades Alcoholic liver disease Prion disease Pertussis Chagas disease Staphylococcus aureus infection Coronavirus disease - COVID-19 Systemic lupus erythematosus Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade +9 more

Complement and coagulation cascades Alcoholic liver disease Pertussis Staphylococcus aureus infection Coronavirus disease - COVID-19 Systemic lupus erythematosus Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade +6 more

Protein processing in endoplasmic reticulum Phagosome Efferocytosis Antigen processing and presentation Chagas disease Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC +14 more

ErbB signaling pathway Calcium signaling pathway cAMP signaling pathway HIF-1 signaling pathway Oocyte meiosis Efferocytosis Necroptosis Adrenergic signaling in cardiomyocytes Wnt signaling pathway Axon guidance Circadian entrainment Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Olfactory transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Oxytocin signaling pathway Glucagon signaling pathway Aldosterone synthesis and secretion Cushing syndrome Gastric acid secretion Parkinson disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Tuberculosis Pathways in cancer Proteoglycans in cancer Glioma Diabetic cardiomyopathy Lipid and atherosclerosis HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Ion transport by P-type ATPases Signaling downstream of RAS mutants +44 more

Protein processing in endoplasmic reticulum Phagosome Antigen processing and presentation Thyroid hormone synthesis Human T-cell leukemia virus 1 infection Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +8 more

Glycine, serine and threonine metabolism Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways Biosynthesis of amino acids Cysteine formation from homocysteine +3 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Chagas disease Malaria Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling +18 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Toll-like receptor signaling pathway Chagas disease Human cytomegalovirus infection Rheumatoid arthritis Lipid and atherosclerosis Chemokine receptors bind chemokines Interleukin-10 signaling +7 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway Cytosolic DNA-sensing pathway Human cytomegalovirus infection Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +7 more

Endocrine resistance FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Apelin signaling pathway Hippo signaling pathway Focal adhesion Tight junction JAK-STAT signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Alcoholic liver disease Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Viral myocarditis SCF(Skp2)-mediated degradation of p27/p21 RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +58 more

FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Hippo signaling pathway Focal adhesion JAK-STAT signaling pathway Prolactin signaling pathway Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity +18 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +4 more

PPAR signaling pathway Phagosome Efferocytosis AMPK signaling pathway ECM-receptor interaction Hematopoietic cell lineage Adipocytokine signaling pathway Insulin resistance Fat digestion and absorption Cholesterol metabolism Malaria Diabetic cardiomyopathy Lipid and atherosclerosis Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation +24 more

Nicotinate and nicotinamide metabolism Metabolic pathways Calcium signaling pathway Hematopoietic cell lineage Oxytocin signaling pathway Salivary secretion Pancreatic secretion Nicotinate metabolism +5 more

Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production Malaria Toxoplasmosis Asthma Autoimmune thyroid disease Systemic lupus erythematosus Allograft rejection Primary immunodeficiency Viral myocarditis Lipid and atherosclerosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway +14 more

Adherens junctions interactions

Cell adhesion molecules Arrhythmogenic right ventricular cardiomyopathy Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Post-translational protein phosphorylation +3 more

FoxO signaling pathway Cell cycle Cellular senescence TGF-beta signaling pathway Cushing syndrome Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis Small cell lung cancer Gastric cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 +12 more

Interleukin-4 and Interleukin-13 signaling HCMV Late Events

Phase I - Functionalization of compounds LDL clearance

Stimuli-sensing channels Signaling by BRAF and RAF fusions

Dectin-2 family

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions NCAM1 interactions Collagen chain trimerization +20 more

Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy TP53 Regulates Metabolic Genes Respiratory electron transport +12 more

Type I diabetes mellitus

Fatty acid degradation Fatty acid metabolism PPAR signaling pathway Efferocytosis AMPK signaling pathway Thermogenesis Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Alcoholic liver disease Diabetic cardiomyopathy Carnitine metabolism Signaling by Retinoic Acid +10 more

MAPK signaling pathway ErbB signaling pathway Rap1 signaling pathway Chemokine signaling pathway Efferocytosis Focal adhesion Fc gamma R-mediated phagocytosis Neurotrophin signaling pathway Regulation of actin cytoskeleton Insulin signaling pathway Growth hormone synthesis, secretion and action Bacterial invasion of epithelial cells Shigellosis Yersinia infection Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer MicroRNAs in cancer Renal cell carcinoma Chronic myeloid leukemia ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis +27 more

Classical antibody-mediated complement activation

Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Melanogenesis Thyroid hormone signaling pathway Cushing syndrome Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Salmonella infection Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Fluid shear stress and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling +51 more

Lysosome Apoptosis COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation +3 more

Vitamin digestion and absorption Cobalamin (Cbl, vitamin B12) transport and metabolism Vitamin D (calciferol) metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1 HDL clearance +3 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Efferocytosis TNF signaling pathway Human cytomegalovirus infection Chemokine receptors bind chemokines G alpha (i) signalling events +5 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway IL-17 signaling pathway TNF signaling pathway Hepatitis C Influenza A Epstein-Barr virus infection Coronavirus disease - COVID-19 Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +12 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Axon guidance Leukocyte transendothelial migration Intestinal immune network for IgA production Regulation of actin cytoskeleton Human cytomegalovirus infection Pathways in cancer Rheumatoid arthritis Nuclear signaling by ERBB4 Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Estrogen-dependent gene expression +13 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Legionellosis Amoebiasis Kaposi sarcoma-associated herpesvirus infection Rheumatoid arthritis Lipid and atherosclerosis Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +14 more

Phagosome Osteoclast differentiation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Leukocyte transendothelial migration Prion disease Leishmaniasis Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping +15 more