Myocardial ischemia

Steroid biosynthesis Metabolic pathways Vitamin D (calciferol) metabolism Vitamins Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) +2 more

Apoptosis TNF signaling pathway Regulation of RAS by GAPs

TGF-beta signaling pathway Cytoskeleton in muscle cells Proteoglycans in cancer Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 +12 more

eNOS activation

eNOS activation

Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Pyruvate metabolism Lipoic acid metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism +8 more

Necroptosis NOD-like receptor signaling pathway TNF signaling pathway Apoptotic execution phase +1 more

MAPK signaling pathway Serotonergic synapse Parkinson disease Fluid shear stress and atherosclerosis RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway +3 more

MAPK signaling pathway Transcriptional misregulation in cancer Acute myeloid leukemia RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway +3 more

Peptide ligand-binding receptors

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Renin secretion Pathways in cancer Peptide ligand-binding receptors G alpha (q) signalling events +6 more

C-type lectin receptor signaling pathway Hepatitis B Human T-cell leukemia virus 1 infection Viral carcinogenesis NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination +3 more

Mitophagy - animal Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Hepatitis C Measles Herpes simplex virus 1 infection Lipid and atherosclerosis PERK regulates gene expression +12 more

Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation +4 more

Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres +2 more

MASTL Facilitates Mitotic Progression

Metabolism of xenobiotics by cytochrome P450 Bile secretion Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Phase I - Functionalization of compounds +3 more

Arachidonic acid metabolism Metabolic pathways Peroxisome Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Biosynthesis of maresins Peroxisomal protein import +5 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Regulation of gene expression by Hypoxia-inducible Factor Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS +8 more

Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE +19 more

Endocrine resistance Hormone signaling Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Endocrine and other factor-regulated calcium reabsorption Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Breast cancer Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression +21 more

Endocrine resistance Hormone signaling Estrogen signaling pathway Prolactin signaling pathway GnRH secretion Pathways in cancer Chemical carcinogenesis - receptor activation Breast cancer PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ESR-mediated signaling Extra-nuclear estrogen signaling +11 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Complement and coagulation cascades Platelet activation Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Coronavirus disease - COVID-19 Pathways in cancer Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Platelet Aggregation (Plug Formation) Regulation of Complement cascade +17 more

Neuroactive ligand-receptor interaction Inflammatory mediator regulation of TRP channels African trypanosomiasis Peptide ligand-binding receptors G alpha (q) signalling events +2 more

Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription +1 more

Complement and coagulation cascades Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins +2 more

PPAR signaling pathway Fat digestion and absorption Triglyceride catabolism

PPAR signaling pathway Triglyceride catabolism Signaling by Retinoic Acid Neutrophil degranulation +1 more

Phagosome Osteoclast differentiation Platelet activation Neutrophil extracellular trap formation Fc gamma R-mediated phagocytosis Pathogenic Escherichia coli infection Yersinia infection Leishmaniasis Staphylococcus aureus infection Tuberculosis Coronavirus disease - COVID-19 Systemic lupus erythematosus FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis +14 more

Phagosome Osteoclast differentiation Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Fc gamma R-mediated phagocytosis Leishmaniasis Staphylococcus aureus infection Tuberculosis Systemic lupus erythematosus Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis +12 more

Axon guidance Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion CRMPs in Sema3A signaling +1 more

Transcriptional misregulation in cancer

Complement and coagulation cascades Platelet activation Neutrophil extracellular trap formation Coronavirus disease - COVID-19 Platelet degranulation Common Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +14 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Hippo signaling pathway Regulation of actin cytoskeleton Pathways in cancer Melanoma Breast cancer Gastric cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer +48 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Melanoma Breast cancer Gastric cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer +56 more

Reversal of alkylation damage by DNA dioxygenases

Viral life cycle - HIV-1 Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Amyloid fiber formation +12 more

Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways Creatine metabolism +1 more

NOD-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation +1 more

Glycolysis / Gluconeogenesis Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways Carbon metabolism Biosynthesis of nucleotide sugars Insulin signaling pathway Insulin secretion Prolactin signaling pathway Glucagon signaling pathway Type II diabetes mellitus Maturity onset diabetes of the young Central carbon metabolism in cancer Regulation of Glucokinase by Glucokinase Regulatory Protein Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis +16 more

Cysteine and methionine metabolism Glutathione metabolism Metabolic pathways Biosynthesis of cofactors Ferroptosis Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) +4 more

Cytokine-cytokine receptor interaction

Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors Gamma-carboxylation of protein precursors +1 more