Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MYOCARDIAL ISCHEMIA	EFO_1001375 C0151744 MESH:D017202	TDRD15	Unknown	39024449	GWAS catalog	—
		TENM2	Unknown	40465716	GWAS catalog	—
		TENT5A	Unknown	30104761	GWAS catalog	—
		TERT	Unknown	—	Disgenet	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TEX2	Unknown	39024449	GWAS catalog	—
		TFRC	Unknown	16214533	CTD, Disgenet	Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis +8 more
		TGFB1	Unknown	39024449	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +49 more
		TGOLN2	Unknown	—	Disgenet	Virion - Hepatitis viruses Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Golgi Associated Vesicle Biogenesis +4 more
		TLE4	Unknown	16214533	CTD, Disgenet	Wnt signaling pathway Notch signaling pathway Formation of the beta-catenin:TCF transactivating complex +2 more
		TLE5	Unknown	16214533	CTD, Disgenet	—
		TLL1	Unknown	—	Disgenet	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation +1 more
		TLR4	Unknown	—	Disgenet	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TMED2	Unknown	16214533	CTD, Disgenet	Pre-NOTCH Processing in Golgi COPII-mediated vesicle transport Cargo concentration in the ER +2 more
		TMPO	Unknown	16214533	CTD, Disgenet	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina
		TNF	Unknown	16214533 16775501	CTD, Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
		TNNT2	Unknown	10789933	CTD, Disgenet	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +4 more
		TP53	Unknown	—	Disgenet	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TRAF6	Unknown	—	Disgenet	MAPK signaling pathway NF-kappa B signaling pathway Ubiquitin mediated proteolysis +61 more
		TRIB1	Unknown	—	Disgenet	NGF-stimulated transcription
		TRPM3	Unknown	30104761	GWAS catalog	TRP channels
		TUBA1A	Unknown	16214533	CTD, Disgenet	Phagosome Apoptosis Tight junction +39 more
		TWIST1	Unknown	30104761 39024449	Disgenet, GWAS catalog	Proteoglycans in cancer Interleukin-4 and Interleukin-13 signaling Regulation of RUNX2 expression and activity
		TXNRD1	Unknown	16214533	CTD, Disgenet	Selenocompound metabolism Pathways in cancer Hepatocellular carcinoma +6 more
		UBASH3B	Unknown	39024449	GWAS catalog	—
		UGCG	Unknown	16214533	CTD, Disgenet	Sphingolipid metabolism Metabolic pathways Glycosphingolipid metabolism
		UQCRFS1	Unknown	16214533	CTD, Disgenet	Oxidative phosphorylation Metabolic pathways Efferocytosis +12 more
		VAMP5	Unknown	—	Disgenet	SNARE interactions in vesicular transport
		VAMP8	Unknown	—	Disgenet	SNARE interactions in vesicular transport Autophagy - animal Platelet activation +7 more
		VCAM1	Unknown	16214533	CTD, Disgenet	NF-kappa B signaling pathway Cell adhesion molecules TNF signaling pathway +10 more
		VDR	Unknown	—	Disgenet	Parathyroid hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Mineral absorption +5 more
		VEGFA	Unknown	11289497 14503966 14583313 15347709 16214533 9860779	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		VEGFB	Unknown	11289497	CTD	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +9 more
		WDR12	Unknown	39024449	Disgenet, GWAS catalog	Major pathway of rRNA processing in the nucleolus and cytosol
		WRN	Unknown	—	Disgenet	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WWP2	Unknown	39024449	GWAS catalog	Ubiquitin mediated proteolysis Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
		XRCC1	Unknown	—	Disgenet	Base excision repair Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway +3 more
		XRCC3	Unknown	—	Disgenet	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +2 more
		ZC3HC1	Unknown	39024449	Disgenet, GWAS catalog	—
		ZEB1	Unknown	16214533	CTD, Disgenet	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFP36	Unknown	16214533	CTD, Disgenet	Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
		ZPR1	Unknown	39024449	GWAS catalog	—

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Myocardial ischemia

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