Myocardial ischemia

Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse

NCAM signaling for neurite out-growth RAF/MAP kinase cascade

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules

Starch and sucrose metabolism Metabolic pathways Necroptosis Insulin signaling pathway Glucagon signaling pathway Insulin resistance Neutrophil degranulation +4 more

RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs

Legionellosis Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs +4 more

RAB geranylgeranylation

Ras signaling pathway Mitophagy - animal Endocytosis Phagosome Efferocytosis Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Salmonella infection Amoebiasis Tuberculosis Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production +15 more

Mitophagy - animal Autophagy - animal Endocytosis Phagosome Efferocytosis Salmonella infection Amoebiasis Tuberculosis MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy +12 more

Ras signaling pathway Pathways in cancer Pancreatic cancer Rho GTPase cycle +1 more

Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport +1 more

Regulation of actin cytoskeleton TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate Formins +4 more

Neuroactive ligand-receptor interaction Relaxin signaling pathway G alpha (s) signalling events G alpha (i) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production +3 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Hepatitis C Influenza A Interferon alpha/beta signaling

PPAR signaling pathway Th17 cell differentiation Thyroid hormone signaling pathway Adipocytokine signaling pathway Parathyroid hormone synthesis, secretion and action Pathways in cancer Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation Thyroid cancer Small cell lung cancer Non-small cell lung cancer Gastric cancer Lipid and atherosclerosis Nuclear Receptor transcription pathway Signaling by Retinoic Acid +12 more

Calcium signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway Circadian entrainment Insulin secretion Oxytocin signaling pathway Pancreatic secretion Prion disease Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Stimuli-sensing channels Ion homeostasis +14 more

Aminoacyl-tRNA biosynthesis Selenocysteine synthesis Cytosolic tRNA aminoacylation

Virion - Hepatitis viruses Phagosome Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Fat digestion and absorption Bile secretion Vitamin digestion and absorption Cholesterol metabolism Hepatitis C Scavenging by Class B Receptors HDL clearance +10 more

Cell adhesion molecules TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications African trypanosomiasis Malaria Lipid and atherosclerosis Fluid shear stress and atherosclerosis Cell surface interactions at the vascular wall +5 more

Cell adhesion molecules Neutrophil extracellular trap formation Malaria Staphylococcus aureus infection Coronavirus disease - COVID-19 Lipid and atherosclerosis Platelet degranulation Cell surface interactions at the vascular wall +5 more

Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation +4 more

HIF-1 signaling pathway p53 signaling pathway Cellular senescence Apelin signaling pathway Hippo signaling pathway Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Chagas disease Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot +10 more

Collagen biosynthesis and modifying enzymes

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters

Calcium signaling pathway cGMP-PKG signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway Olfactory transduction Endocrine and other factor-regulated calcium reabsorption Protein digestion and absorption Mineral absorption Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis +12 more

FoxO signaling pathway Cell cycle Endocytosis Cellular senescence Wnt signaling pathway TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Diabetic cardiomyopathy Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling FOXO-mediated transcription of cell cycle genes +34 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination +6 more

SNARE interactions in vesicular transport Platelet activation ER-Phagosome pathway trans-Golgi Network Vesicle Budding Neutrophil degranulation +2 more

Steroid biosynthesis Cholesterol metabolism LDL clearance

Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway TNF signaling pathway Insulin signaling pathway Prolactin signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Growth hormone synthesis, secretion and action Hepatitis C Influenza A Herpes simplex virus 1 infection Interleukin-6 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 Neddylation Interferon alpha/beta signaling Antigen processing: Ubiquitination & Proteasome degradation +19 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Detoxification of Reactive Oxygen Species

Lysosome Neurotrophin signaling pathway Cholesterol metabolism Golgi Associated Vesicle Biogenesis +1 more

Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors +1 more

AMPK signaling pathway Insulin signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease RORA activates gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +7 more

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression +4 more

ErbB signaling pathway Hormone signaling Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Prolactin signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Hepatitis B Measles Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Nuclear signaling by ERBB4 Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Growth hormone receptor signaling +28 more

Telomere C-strand synthesis initiation

Chemical carcinogenesis - DNA adducts Cytosolic sulfonation of small molecules

ABC transporters Phagosome Antigen processing and presentation Human cytomegalovirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Primary immunodeficiency ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC +7 more

Wnt signaling pathway Hippo signaling pathway Adherens junction Melanogenesis Cushing syndrome Alcoholic liver disease Salmonella infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes TCF7L2 mutants don't bind CTBP Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling +26 more