Myocardial ischemia

ABC transporters Efferocytosis Fat digestion and absorption Cholesterol metabolism Lipid and atherosclerosis PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +6 more

ABC transporters ABC-family proteins mediated transport Defective ABCC6 causes pseudoxanthoma elasticum (PXE)

ABC transporters Fat digestion and absorption Bile secretion Cholesterol metabolism ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +5 more

ABC transporters Fat digestion and absorption Bile secretion Cholesterol metabolism ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +5 more

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways ABO blood group biosynthesis +1 more

Fatty acid degradation Valine, leucine and isoleucine degradation Lysine degradation Tryptophan metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Butanoate metabolism Terpenoid backbone biosynthesis Metabolic pathways Carbon metabolism Fatty acid metabolism Fat digestion and absorption Cholesterol biosynthesis +10 more

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Ovarian steroidogenesis Mitochondrial Fatty Acid Beta-Oxidation Peroxisomal protein import +3 more

Thiamine metabolism Riboflavin metabolism Metabolic pathways Adherens junction Chemical carcinogenesis - reactive oxygen species +2 more

ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome Apoptosis Hippo signaling pathway Focal adhesion Adherens junction Tight junction Platelet activation Neutrophil extracellular trap formation Leukocyte transendothelial migration Thermogenesis Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Thyroid hormone signaling pathway Oxytocin signaling pathway Gastric acid secretion Amyotrophic lateral sclerosis Bacterial invasion of epithelial cells Vibrio cholerae infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Influenza A Proteoglycans in cancer Hepatocellular carcinoma Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Fluid shear stress and atherosclerosis Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis +54 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

PPAR signaling pathway Hormone signaling AMPK signaling pathway Longevity regulating pathway Adipocytokine signaling pathway Type II diabetes mellitus Non-alcoholic fatty liver disease Alcoholic liver disease AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation +7 more

Neuroactive ligand-receptor interaction Vascular smooth muscle contraction G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production +2 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Gap junction Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +12 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production +13 more

Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Thermogenesis Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +9 more

Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Pathways of neurodegeneration - multiple diseases Diabetic cardiomyopathy Lipid and atherosclerosis TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Pathways in cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +18 more

Calcium signaling pathway cGMP-PKG signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Coronavirus disease - COVID-19 Pathways in cancer Diabetic cardiomyopathy Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +18 more

Alanine, aspartate and glutamate metabolism Glycine, serine and threonine metabolism Cysteine and methionine metabolism Valine, leucine and isoleucine degradation Metabolic pathways 2-Oxocarboxylic acid metabolism Glyoxylate metabolism and glycine degradation +4 more

Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation +1 more

Purine metabolism Thiamine metabolism Metabolic pathways Nucleotide metabolism Biosynthesis of cofactors Interconversion of nucleotide di- and triphosphates +3 more

Valine, leucine and isoleucine degradation beta-Alanine metabolism Inositol phosphate metabolism Propanoate metabolism Metabolic pathways Carbon metabolism Branched-chain amino acid catabolism +4 more

Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids HIF-1 signaling pathway Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis +8 more

Fc epsilon RI signaling pathway Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) +1 more

Purine metabolism Metabolic pathways Nucleotide metabolism Cytoskeleton in muscle cells Purine salvage +2 more

PPAR signaling pathway Cholesterol metabolism PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes +2 more

Amyloid fiber formation

Notch signaling pathway Alzheimer disease Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation +8 more

Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

PPAR signaling pathway Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism African trypanosomiasis Lipid and atherosclerosis Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes Tangier disease Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Retinoid metabolism and transport Amyloid fiber formation +19 more

PPAR signaling pathway PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron remodeling +2 more

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism VLDL assembly VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +1 more

PPAR signaling pathway Cholesterol metabolism Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport +3 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Retinoid metabolism and transport

MAPK signaling pathway ErbB signaling pathway PI3K-Akt signaling pathway Hippo signaling pathway Colorectal cancer PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling +19 more

Rho GTPase cycle

Rho GTPase cycle

Vascular smooth muscle contraction Axon guidance Platelet activation C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Yersinia infection Tuberculosis Human cytomegalovirus infection Pathways in cancer Proteoglycans in cancer NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse +12 more

cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Cytoskeleton in muscle cells Insulin secretion Thyroid hormone synthesis Thyroid hormone signaling pathway Aldosterone synthesis and secretion Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Proximal tubule bicarbonate reclamation Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Protein digestion and absorption Bile secretion Mineral absorption Ion homeostasis Ion transport by P-type ATPases +18 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption Salivary secretion Pancreatic secretion Mineral absorption Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +9 more

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Colorectal cancer Endometrial cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases +15 more

Rap1 signaling pathway Chemokine signaling pathway Efferocytosis Focal adhesion Leukocyte transendothelial migration Regulation of actin cytoskeleton Growth hormone synthesis, secretion and action Bacterial invasion of epithelial cells Shigellosis Yersinia infection Human cytomegalovirus infection Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +12 more

Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin

Circadian rhythm