Metabolic syndrome

Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling

Virion - Lassa virus and SFTS virus

Virion - Lassa virus and SFTS virus

Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways PPAR signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Insulin signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Proximal tubule bicarbonate reclamation Transcriptional regulation of white adipocyte differentiation Gluconeogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis +13 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more

Peptide hormone biosynthesis Synthesis, secretion, and deacylation of Ghrelin

Purine metabolism Metabolic pathways cAMP signaling pathway Morphine addiction cGMP effects G alpha (s) signalling events +3 more

Purine metabolism Metabolic pathways Calcium signaling pathway Olfactory transduction Taste transduction Renin secretion Morphine addiction Cam-PDE 1 activation cGMP effects G alpha (s) signalling events +7 more

Purine metabolism Metabolic pathways Calcium signaling pathway Olfactory transduction Taste transduction Renin secretion Morphine addiction Cam-PDE 1 activation +5 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway cAMP signaling pathway Renin secretion Morphine addiction G alpha (s) signalling events +4 more

Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction DARPP-32 events +3 more

Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction DARPP-32 events G alpha (s) signalling events +4 more

Purine metabolism Metabolic pathways Cortisol synthesis and secretion Cushing syndrome Morphine addiction G alpha (s) signalling events +3 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Prostate cancer Melanoma Choline metabolism in cancer Signaling by PDGF +11 more

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion +2 more

Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Glycerophospholipid metabolism Metabolic pathways

HDMs demethylate histones

NF-kappa B signaling pathway Ubiquitin mediated proteolysis JAK-STAT signaling pathway Fluid shear stress and atherosclerosis Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +14 more

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Autophagy - other Autophagy - animal Phagosome Apelin signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Tuberculosis Kaposi sarcoma-associated herpesvirus infection PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases +20 more

Synthesis of PI

Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint +3 more

Keratinization Formation of the cornified envelope

Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways Ras signaling pathway Efferocytosis Vascular smooth muscle contraction Fc gamma R-mediated phagocytosis Inflammatory mediator regulation of TRP channels Acyl chain remodelling of PC Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic +12 more

Inositol phosphate metabolism Metabolic pathways Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Chemokine signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Wnt signaling pathway Apelin signaling pathway Gap junction Platelet activation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Taste transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Alzheimer disease Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Chagas disease African trypanosomiasis Amoebiasis Human cytomegalovirus infection Pathways in cancer Diabetic cardiomyopathy Lipid and atherosclerosis PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol G alpha (q) signalling events +62 more

Inositol phosphate metabolism Metabolic pathways Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Phosphatidylinositol signaling system Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications Shigellosis Proteoglycans in cancer Synthesis of IP3 and IP4 in the cytosol +9 more

GABAergic synapse

Synthesis of PIPs at the plasma membrane

Neuroactive ligand-receptor interaction Complement and coagulation cascades Staphylococcus aureus infection Influenza A Platelet degranulation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot +7 more

FoxO signaling pathway TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response

Glycerolipid metabolism Glycerophospholipid metabolism Ether lipid metabolism Sphingolipid metabolism Metabolic pathways Phospholipase D signaling pathway Fc gamma R-mediated phagocytosis Fat digestion and absorption Choline metabolism in cancer Sphingolipid de novo biosynthesis +7 more

PPAR signaling pathway Cholesterol metabolism HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +1 more