Metabolic syndrome

Pancreatic secretion Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs +1 more

RAB geranylgeranylation

Endocytosis TBC/RABGAPs

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Phagosome Efferocytosis PI3K-Akt signaling pathway Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Adherens junction Tight junction Neutrophil extracellular trap formation Toll-like receptor signaling pathway Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Regulation of actin cytoskeleton Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Pancreatic secretion Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Choline metabolism in cancer Diabetic cardiomyopathy Viral myocarditis Lipid and atherosclerosis Fluid shear stress and atherosclerosis GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Nef and signal transduction NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 NTRK2 activates RAC1 FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Factors involved in megakaryocyte development and platelet production +89 more

Nucleocytoplasmic transport

Nucleocytoplasmic transport Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation +8 more

Pathways in cancer Small cell lung cancer Non-small cell lung cancer Gastric cancer Nuclear Receptor transcription pathway Signaling by Retinoic Acid +3 more

MAPK signaling pathway Ras signaling pathway Viral carcinogenesis Regulation of RAS by GAPs +1 more

MAPK signaling pathway Ras signaling pathway Focal adhesion RAF/MAP kinase cascade +1 more

Cushing syndrome Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation +3 more

Notch signaling pathway Th1 and Th2 cell differentiation Spinocerebellar ataxia Human papillomavirus infection Epstein-Barr virus infection Viral carcinogenesis Pre-NOTCH Transcription and Translation NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription +12 more

Thyroid hormone signaling pathway

Olfactory Signaling Pathway

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Spinocerebellar ataxia Human papillomavirus infection Reelin signalling pathway +3 more

Neutrophil degranulation

Defective RFT1 causes RFT1-CDG (CDG-1n)

G alpha (i) signalling events

Rap1 signaling pathway G alpha (i) signalling events

G alpha (q) signalling events G alpha (i) signalling events G alpha (z) signalling events

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Endocytosis Necroptosis Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III +4 more

Antigen processing: Ubiquitination & Proteasome degradation

Polycomb repressive complex Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 +6 more

Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO

Wnt signaling pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Th17 cell differentiation Circadian rhythm Spinocerebellar ataxia Inflammatory bowel disease RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling +7 more

Hedgehog 'off' state Anchoring of the basal body to the plasma membrane

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +10 more

Autophagy - other Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Thermogenesis Insulin signaling pathway Shigellosis MicroRNAs in cancer Macroautophagy mTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1 +16 more

RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape

Wnt signaling pathway Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins +1 more

Alzheimer disease Axonal growth inhibition (RHOA activation)

Post-translational modification: synthesis of GPI-anchored proteins

Neutrophil degranulation