Metabolic syndrome

mRNA surveillance pathway

Phase I - Functionalization of compounds

Neuroactive ligand-receptor interaction Circadian entrainment Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events +1 more

Neutrophil degranulation

Motor proteins Cytoskeleton in muscle cells

Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway Focal adhesion Adherens junction Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Shigellosis Salmonella infection Hypertrophic cardiomyopathy Dilated cardiomyopathy Striated Muscle Contraction +12 more

Motor proteins

Motor proteins Pathogenic Escherichia coli infection

Motor proteins Pathogenic Escherichia coli infection

COPI-dependent Golgi-to-ER retrograde traffic

Virion - Ebolavirus, Lyssavirus and Morbillivirus Cell adhesion molecules Prion disease NCAM signaling for neurite out-growth NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling +5 more

Lysosome

Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +11 more

Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis

Thermogenesis Complex I biogenesis

Oxidative phosphorylation Metabolic pathways Thermogenesis Retrograde endocannabinoid signaling Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Respiratory electron transport Complex I biogenesis +12 more

Cytoskeleton in muscle cells

Virion - Herpesvirus Cell adhesion molecules Adherens junction Herpes simplex virus 1 infection Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization +4 more

Cell adhesion molecules Post-translational modification: synthesis of GPI-anchored proteins

Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1 +2 more

TGF-beta signaling pathway Axon guidance Cell adhesion molecules

Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) +24 more

Circadian rhythm

Cell adhesion molecules Neurexins and neuroligins

DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more

Virion - Ebolavirus, Lyssavirus and Morbillivirus Lysosome Cholesterol metabolism LDL clearance +1 more

Lysosome Cholesterol metabolism Neutrophil degranulation LDL clearance +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Alcoholism Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +5 more

Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1 +2 more

Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) +24 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more