Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LUNG NEOPLASMS	MESH:D008175	KRAS	Unknown	10223196 10545420 10874023 11641043 11745231 11884234 12376484 12725029 16247444 16271038 16289808 16410370 16823377 17233834 17290066 17325976 18062963 18758463 18927287 19336973 19424582 19555203 20101149 21519798 22028818 25851	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LECT2	Unknown	30453282	CTD	—
		LMNTD1	Unknown	15064703	CTD	—
		MAP2K7	Unknown	21317887	CTD	MAPK signaling pathway ErbB signaling pathway Protein processing in endoplasmic reticulum +26 more
		MAP3K8	Unknown	—	CTD	MAPK signaling pathway Toll-like receptor signaling pathway T cell receptor signaling pathway +3 more
		MAP4K4	Unknown	27935865	CTD	MAPK signaling pathway Oxidative Stress Induced Senescence
		MAPK1	Unknown	11884234 12376484	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAPK14	Unknown	17468755	CTD	Endocrine resistance MAPK signaling pathway Rap1 signaling pathway +75 more
		MAPK3	Unknown	11884234 12083368	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +158 more
		MARCKS	Unknown	27935865	CTD	Fc gamma R-mediated phagocytosis MicroRNAs in cancer Acetylcholine regulates insulin secretion
		MCL1	Unknown	19903766 27935865	CTD	PI3K-Akt signaling pathway Apoptosis JAK-STAT signaling pathway +2 more
		MET	Unknown	20934974	CTD	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MMP1	Unknown	23548910	CTD	PPAR signaling pathway IL-17 signaling pathway Relaxin signaling pathway +11 more
		MMP10	Unknown	22022614	CTD	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
		MPO	Unknown	12111688	CTD	Drug metabolism - other enzymes Phagosome Neutrophil extracellular trap formation +4 more
		MPP1	Unknown	21552421	CTD	—
		MTHFR	Unknown	17389614	CTD	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		MUC12	Unknown	29054765	CTD	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC16	Unknown	29552305	CTD	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYC	Unknown	16289808 28191284	CTD	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYO18B	Unknown	29054765	CTD	Motor proteins
		NFE2L2	Unknown	31227482	CTD	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFYA	Unknown	16271038	CTD	Antigen processing and presentation Spinocerebellar ataxia Tuberculosis +3 more
		NOS2	Unknown	12460898 22369883	CTD	Arginine biosynthesis Arginine and proline metabolism Metabolic pathways +21 more
		NOTCH2	Unknown	17804716	CTD	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NOTCH3	Unknown	17804716	CTD	Endocrine resistance Notch signaling pathway Apelin signaling pathway +13 more
		NPPA	Unknown	18717826	CTD	cGMP-PKG signaling pathway cAMP signaling pathway HIF-1 signaling pathway +11 more
		NRG1	Unknown	28604730	CTD	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		OGG1	Unknown	17441966 19336973	CTD	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +7 more
		PCNA	Unknown	11884234	CTD	DNA replication Base excision repair Nucleotide excision repair +29 more
		PDCD1	Unknown	34166680	CTD	Cell adhesion molecules T cell receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		PDCD4	Unknown	27323401	CTD	Proteoglycans in cancer MicroRNAs in cancer Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		PDLIM4	Unknown	27935865	CTD	Cytoskeleton in muscle cells
		PGGT1B	Unknown	22028818	CTD	—
		PIK3CA	Unknown	—	CTD	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PON1	Unknown	16323636	CTD	Synthesis of 5-eicosatetraenoic acids
		PPBP	Unknown	27935865	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +4 more
		PPP2R1B	Unknown	—	CTD	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +42 more
		PRDX1	Unknown	22537621	CTD	Peroxisome Cobalamin transport and metabolism Amoebiasis +2 more
		PRDX6	Unknown	23692979	CTD	Glutathione metabolism Metabolic pathways Detoxification of Reactive Oxygen Species +1 more
		PRKN	Unknown	19946270 25640678	CTD	Ubiquitin mediated proteolysis Mitophagy - animal Protein processing in endoplasmic reticulum +8 more
		PTEN	Unknown	17909629 27980214	CTD	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTGIS	Unknown	11830527	CTD	Arachidonic acid metabolism Metabolic pathways Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol +6 more
		PTMA	Unknown	10822126	CTD	—
		PYCARD	Unknown	16778195	CTD	Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway +13 more
		RAD52	Unknown	26013599	CTD	Homologous recombination SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA)
		RAF1	Unknown	11884234 38245882	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RAMP2	Unknown	17671114	CTD	Hormone signaling Vascular smooth muscle contraction G alpha (s) signalling events +2 more
		RARB	Unknown	14656941	CTD	Pathways in cancer Small cell lung cancer Non-small cell lung cancer +3 more
		RASSF1	Unknown	18337602	CTD	Ras signaling pathway Hippo signaling pathway Hippo signaling pathway - multiple species +4 more

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Lung neoplasms

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