Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LUNG NEOPLASMS	MESH:D008175	RCHY1	Unknown	28191284	CTD	p53 signaling pathway Ubiquitin mediated proteolysis Measles +2 more
		RIOX2	Unknown	15897898	CTD	HDMs demethylate histones
		RNASET2	Unknown	28604730	CTD	Neutrophil degranulation
		ROBO1	Unknown	17671114	CTD	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO +3 more
		RTEL1	Unknown	28604730	CTD	Telomere Extension By Telomerase Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
		RUNX3	Unknown	21552421	CTD	Th1 and Th2 cell differentiation Epstein-Barr virus infection Binding of TCF/LEF:CTNNB1 to target gene promoters +9 more
		SECISBP2L	Unknown	28604730	CTD	—
		SELENBP1	Unknown	14991897	CTD	Sulfur metabolism Metabolic pathways
		SELENOP	Unknown	19058871	CTD	Platelet degranulation
		SERPINA1	Unknown	17902193	CTD	Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport +4 more
		SERPING1	Unknown	27935865	CTD	Complement and coagulation cascades Pertussis Platelet degranulation +2 more
		SFTPB	Unknown	16570259	CTD	Surfactant metabolism Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) +1 more
		SFTPD	Unknown	14522914 15136449	CTD	Phagosome Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade +6 more
		SIDT2	Unknown	27935865	CTD	—
		SLC3A2	Unknown	26621329	CTD	mTOR signaling pathway Ferroptosis Protein digestion and absorption +4 more
		SLC67A1	Unknown	—	CTD	—
		SLC7A5	Unknown	26621329	CTD	mTOR signaling pathway Central carbon metabolism in cancer Basigin interactions +2 more
		SLCO1B3	Unknown	22326869 25625007	CTD	Bile secretion Folate transport and metabolism Recycling of bile acids and salts +3 more
		SMARCC1	Unknown	21552421	CTD	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMC2	Unknown	27935865	CTD	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes
		SND1	Unknown	25940438	CTD	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SOX2	Unknown	19801978	CTD	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SOX30	Unknown	25435374	CTD	—
		SOX9	Unknown	27935865	CTD	cAMP signaling pathway Deactivation of the beta-catenin transactivating complex Transcriptional regulation by RUNX2
		SPP1	Unknown	21552421 22481206	CTD	PI3K-Akt signaling pathway Apelin signaling pathway Focal adhesion +10 more
		SPRY2	Unknown	15136453	CTD	MicroRNAs in cancer Spry regulation of FGF signaling EGFR downregulation
		STAT3	Unknown	38101582	CTD	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5A	Unknown	21552421	CTD	ErbB signaling pathway Hormone signaling Necroptosis +28 more
		STIM1	Unknown	27863410	CTD	Calcium signaling pathway Platelet activation Ion homeostasis +1 more
		STK11	Unknown	17676035	CTD	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STN1	Unknown	28604730	CTD	Telomere C-strand synthesis initiation
		TEP1	Unknown	11323394	CTD	—
		TERT	Unknown	11323394 19151717 23433592	CTD	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TFRC	Unknown	16904380	CTD	Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis +8 more
		TGFB1	Unknown	11074608 11641043 17418594	CTD	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +49 more
		TGFBR2	Unknown	11074608	CTD	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TLR4	Unknown	19925653	CTD	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TMEM45A	Unknown	27935865	CTD	—
		TNF	Unknown	14587096 22369883	CTD	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
		TP53	Unknown	11798837 16410370 17325666 20727180 26192916 8049841	CTD	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	20871597 21725308	CTD	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TP73	Unknown	28212736	CTD	p53 signaling pathway Hippo signaling pathway Neurotrophin signaling pathway +8 more
		TSC2	Unknown	30008631	CTD	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	9062474	CTD	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		TTR	Unknown	17902193 19180532	CTD	Thyroid hormone synthesis Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) +4 more
		TYMS	Unknown	18281538 19020767	CTD	Pyrimidine metabolism One carbon pool by folate Metabolic pathways +5 more
		TYRP1	Unknown	21552421	CTD	Tyrosine metabolism Metabolic pathways Melanogenesis +1 more
		UGT2B17	Unknown	17416778	CTD	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Steroid hormone biosynthesis +11 more
		USP18	Unknown	27980214	CTD	ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling
		VHL	Unknown	16061637	CTD	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more

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Lung neoplasms

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