Lung neoplasms

Purine metabolism Metabolic pathways Small cell lung cancer Non-small cell lung cancer +1 more

Endocrine resistance MAPK signaling pathway cAMP signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Circadian entrainment Cholinergic synapse Dopaminergic synapse Estrogen signaling pathway Prolactin signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Non-alcoholic fatty liver disease Growth hormone synthesis, secretion and action Amphetamine addiction Pathogenic Escherichia coli infection Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Breast cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling +51 more

Osteoclast differentiation IL-17 signaling pathway Cocaine addiction Amphetamine addiction Alcoholism Estrogen-dependent gene expression NGF-stimulated transcription +4 more

Osteoclast differentiation

Cellular senescence Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition

Th17 cell differentiation Inflammatory bowel disease RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling +1 more

Hormone signaling Gastric acid secretion G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK +1 more

Surfactant metabolism Factors involved in megakaryocyte development and platelet production

Vitamin D (calciferol) metabolism

Cysteine and methionine metabolism Glutathione metabolism Metabolic pathways Biosynthesis of cofactors Ferroptosis Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) +4 more

Taurine and hypotaurine metabolism Glutathione metabolism Arachidonic acid metabolism Metabolic pathways Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production +5 more

Gap junction Arrhythmogenic right ventricular cardiomyopathy Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction degradation Regulation of gap junction activity Formation of annular gap junctions +4 more

Oligomerization of connexins into connexons Gap junction assembly

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism +7 more

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Detoxification of Reactive Oxygen Species +4 more

GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling +2 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Prostate cancer Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation +11 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Fanconi anemia pathway Notch signaling pathway Maturity onset diabetes of the young Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX3 regulates NOTCH signaling NOTCH4 Intracellular Domain Regulates Transcription +8 more

Notch signaling pathway Human papillomavirus infection Pathways in cancer Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH4 Intracellular Domain Regulates Transcription +4 more

Lipid particle organization

Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway Ferroptosis Mineral absorption Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane +11 more

Maturity onset diabetes of the young

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Chemokine signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal Endocytosis mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Apelin signaling pathway Focal adhesion Gap junction Signaling pathways regulating pluripotency of stem cells C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Thermogenesis Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway GnRH secretion AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Salmonella infection Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB4 signaling Signaling by SCF-KIT p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling FCERI mediated MAPK activation NCAM signaling for neurite out-growth EPHB-mediated forward signaling VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS GTPase cycle mutants Signaling downstream of RAS mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants +134 more

Degradation of the extracellular matrix

TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription

Glycosaminoglycan degradation Metabolic pathways Lysosome HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome +3 more

Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Type I diabetes mellitus Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Influenza A Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Fluid shear stress and atherosclerosis Interferon gamma signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +33 more

Autophagy - other Autophagy - animal

Antifolate resistance MAPK signaling pathway Ras signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway PI3K-Akt signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Adipocytokine signaling pathway Alcoholic liver disease Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Chagas disease Toxoplasmosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - reactive oxygen species Pancreatic cancer Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Primary immunodeficiency Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation +76 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway Efferocytosis C-type lectin receptor signaling pathway JAK-STAT signaling pathway T cell receptor signaling pathway Intestinal immune network for IgA production Pertussis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Staphylococcus aureus infection Tuberculosis Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Allograft rejection Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis +25 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Inflammatory mediator regulation of TRP channels Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Measles Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Lipid and atherosclerosis Fluid shear stress and atherosclerosis Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +47 more

Cytokine-cytokine receptor interaction Hematopoietic cell lineage Amoebiasis Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer Prostate cancer Fluid shear stress and atherosclerosis Interleukin-10 signaling Interleukin-1 signaling +6 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Intestinal immune network for IgA production Type I diabetes mellitus Yersinia infection Chagas disease Measles Human T-cell leukemia virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Autoimmune thyroid disease Inflammatory bowel disease Allograft rejection Graft-versus-host disease RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling +21 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway Interleukin-20 family signaling +1 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

Endocytosis

C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway Pertussis Human papillomavirus infection Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production +5 more

Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling +1 more

Endocrine resistance Notch signaling pathway Apelin signaling pathway Th1 and Th2 cell differentiation TNF signaling pathway Human papillomavirus infection Pathways in cancer Chemical carcinogenesis - receptor activation Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX3 regulates NOTCH signaling NOTCH3 Activation and Transmission of Signal to the Nucleus +12 more

Endocrine resistance MAPK signaling pathway ErbB signaling pathway cAMP signaling pathway Mitophagy - animal Apoptosis Wnt signaling pathway Osteoclast differentiation Focal adhesion Tight junction Toll-like receptor signaling pathway NOD-like receptor signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Neurotrophin signaling pathway GnRH signaling pathway Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Cocaine addiction Amphetamine addiction Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Breast cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping +63 more

Osteoclast differentiation TNF signaling pathway Growth hormone synthesis, secretion and action SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Interleukin-4 and Interleukin-13 signaling NGF-stimulated transcription +3 more

MAPK signaling pathway Osteoclast differentiation IL-17 signaling pathway Parathyroid hormone synthesis, secretion and action Estrogen-dependent gene expression NGF-stimulated transcription +3 more

Gastric acid secretion Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Focal adhesion Proteoglycans in cancer Fluid shear stress and atherosclerosis Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB +13 more