Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HEART FAILURE	EFO_0003144 C0018801 MESH:D006333	CRTC1	Unknown	40195560	GWAS catalog	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CRYM	Unknown	36071497	CTD, Disgenet	Lysine catabolism
		CS	Unknown	8922916	CTD, Disgenet	Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Metabolic pathways +4 more
		CSF2	Unknown	11732872	CTD, Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage +18 more
		CSF3	Unknown	15585077	CTD, Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +6 more
		CWC27	Unknown	40195560	GWAS catalog	mRNA Splicing - Major Pathway
		CXCL2	Unknown	22352330	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +14 more
		CXCL8	Unknown	29959987	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +37 more
		CYB5B	Unknown	37429843	GWAS catalog	Phase I - Functionalization of compounds
		CYBB	Unknown	20304815	CTD, Disgenet	HIF-1 signaling pathway Phagosome Ferroptosis +18 more
		CYTH1	Unknown	41184235	GWAS catalog	Phospholipase D signaling pathway Endocytosis Pathogenic Escherichia coli infection +3 more
		DERL3	Unknown	36376295	GWAS catalog	Protein processing in endoplasmic reticulum ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis
		DMAC2	Unknown	36376295	GWAS catalog	—
		DNAH2	Unknown	27790247	GWAS catalog	Motor proteins Amyotrophic lateral sclerosis Huntington disease +1 more
		DNAH8	Unknown	40195560	GWAS catalog	Motor proteins Amyotrophic lateral sclerosis Huntington disease +1 more
		DNAJB4	Unknown	40195560	GWAS catalog	—
		DNAJC18	Unknown	36376295 40195560	GWAS catalog	—
		DOK2	Unknown	40195560	GWAS catalog	Tie2 Signaling RET signaling
		DPY19L4	Unknown	41184235	GWAS catalog	—
		DSTN	Unknown	29394407	CTD, Disgenet	—
		DUSP6	Unknown	40195560	GWAS catalog	MAPK signaling pathway Transcriptional misregulation in cancer Acute myeloid leukemia +3 more
		DYSF	Unknown	36376295	GWAS catalog	Smooth Muscle Contraction
		E2F1	Unknown	36376295	GWAS catalog	Endocrine resistance Cell cycle Mitophagy - animal +38 more
		E2F6	Unknown	40195560	GWAS catalog	Polycomb repressive complex G1/S-Specific Transcription Transcriptional Regulation by E2F6
		EBF1	Unknown	40195560	GWAS catalog	—
		ECE2	Unknown	40195560	GWAS catalog	Peptide ligand-binding receptors
		EDN1	Unknown	11136700 11707688 16360360 16762801 7967349 7969316 9861300	CTD, Disgenet	cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction +11 more
		EDNRA	Unknown	28095452 40195560	CTD, Disgenet, GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +6 more
		EDNRB	Unknown	28095452	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +5 more
		EEF1AKMT4-ECE2	Unknown	40195560	GWAS catalog	Peptide ligand-binding receptors
		ELOVL6	Unknown	26670611	CTD, Disgenet	Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways +3 more
		EP300	Unknown	—	Disgenet	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPHX2	Unknown	18443590	CTD, Disgenet	Arachidonic acid metabolism Metabolic pathways Peroxisome +5 more
		EPO	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling +8 more
		EVI5	Unknown	40195560	GWAS catalog	—
		EYA4	Unknown	—	Disgenet	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		EZH2	Unknown	—	Disgenet	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FADS1	Unknown	27790247	GWAS catalog	Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism +3 more
		FADS2	Unknown	27790247	GWAS catalog	alpha-Linolenic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways +4 more
		FAF1	Unknown	36376295 40195560 41184235	GWAS catalog	—
		FASN	Unknown	26670611	CTD, Disgenet	Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism +8 more
		FBLN5	Unknown	12189163	CTD, Disgenet	Elastic fibre formation Molecules associated with elastic fibres
		FBXL20	Unknown	40195560	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FERD3L	Unknown	27790247	GWAS catalog	—
		FGF5	Unknown	40195560	GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +40 more
		FIP1L1	Unknown	28347583	CTD, Disgenet	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FLNC	Unknown	36376295 39024449	GWAS catalog	Cytoskeleton in muscle cells Cell-extracellular matrix interactions
		FOXN3	Unknown	36376295 40195560	GWAS catalog	—
		FOXP1	Unknown	40195560	GWAS catalog	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FTO	Unknown	27790247 31919418 33910581 36376295 36777996 37429843 39024449 40195560 41184235	GWAS catalog	Reversal of alkylation damage by DNA dioxygenases

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Heart failure

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