Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HEART FAILURE	C0018801 MESH:D006333 EFO_0003144	ATP2A2	Unknown	19776660	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		ATP2B1	Unknown	27790247	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATXN2	Unknown	31919418 36376295 40195560 41184235	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		AVEN	Unknown	34594039	GWAS catalog	Formation of apoptosome Regulation of the apoptosome activity
		AVP	Unknown	18179782	CTD, Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +12 more
		AVPR2	Unknown	12145768	CTD, Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +8 more
		BACE2	Unknown	40195560	GWAS catalog	Alzheimer disease
		BACH1	Unknown	37429843	GWAS catalog	—
		BAG3	Unknown	31919418 36376295 37429843 39024449 40195560 41184235	GWAS catalog	Regulation of HSF1-mediated heat shock response
		BAMBI	Unknown	29394407	CTD, Disgenet	Wnt signaling pathway TGF-beta signaling pathway Downregulation of TGF-beta receptor signaling
		BAZ1B	Unknown	27790247	GWAS catalog	ATP-dependent chromatin remodeling B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCL3	Unknown	27790247	GWAS catalog	C-type lectin receptor signaling pathway TNF signaling pathway
		BDNF	Unknown	40195560	GWAS catalog	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		BMAL1	Unknown	40195560	GWAS catalog	—
		BPTF	Unknown	37429843 40195560	GWAS catalog	ATP-dependent chromatin remodeling
		BRWD1	Unknown	40195560	GWAS catalog	Interleukin-7 signaling Chromatin modifying enzymes
		BSX	Unknown	27790247	GWAS catalog	—
		CACNA1D	Unknown	40195560 41184235	GWAS catalog	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CACNB2	Unknown	36376295	GWAS catalog	MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes +8 more
		CAMK2D	Unknown	37429843 40195560	GWAS catalog	ErbB signaling pathway Calcium signaling pathway cAMP signaling pathway +44 more
		CAND2	Unknown	40195560 41184235	GWAS catalog	—
		CAST	Unknown	40195560	GWAS catalog	Shigellosis Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
		CASZ1	Unknown	40195560 41184235	GWAS catalog	—
		CAT	Unknown	16105639	CTD, Disgenet	Tryptophan metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways +11 more
		CAV1	Unknown	40195560	GWAS catalog	Endocytosis Focal adhesion Prion disease +11 more
		CBL	Unknown	—	Disgenet	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CCDC136	Unknown	36376295 39024449	GWAS catalog	—
		CCDC141	Unknown	36376295	GWAS catalog	—
		CCDC171	Unknown	40195560	GWAS catalog	—
		CCL2	Unknown	29959987	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +18 more
		CCN2	Unknown	17229371	CTD, Disgenet	Apelin signaling pathway Hippo signaling pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression +1 more
		CCR2	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +4 more
		CDC16	Unknown	40195560	GWAS catalog	Cell cycle Oocyte meiosis Ubiquitin mediated proteolysis +18 more
		CDK6	Unknown	36376295 40195560 41184235	GWAS catalog	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +27 more
		CDKN1A	Unknown	31919418 36376295 37429843 39024449 40195560	GWAS catalog	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more
		CELSR2	Unknown	27790247 31919418 37429843 40195560	GWAS catalog	—
		CEP85L	Unknown	36376295	GWAS catalog	—
		CERT1	Unknown	27790247	GWAS catalog	Sphingolipid de novo biosynthesis
		CETP	Unknown	27790247	GWAS catalog	Cholesterol metabolism LDL remodeling HDL remodeling +1 more
		CFD	Unknown	26670611	CTD, Disgenet	Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 +3 more
		CFDP1	Unknown	40195560	GWAS catalog	—
		CH25H	Unknown	20445134	GWAS catalog	Primary bile acid biosynthesis Efferocytosis Synthesis of bile acids and bile salts
		CHDH	Unknown	36071497	CTD, Disgenet	Glycine, serine and threonine metabolism One carbon pool by folate Metabolic pathways +1 more
		CHMP3	Unknown	36376295	GWAS catalog	Endocytosis Necroptosis Budding and maturation of HIV virion +4 more
		CIDEA	Unknown	26670611	CTD, Disgenet	AMPK signaling pathway Lipid particle organization
		CLCNKA	Unknown	36376295 39024449 40195560 41184235	GWAS catalog	Stimuli-sensing channels
		CMIP	Unknown	40195560	GWAS catalog	—
		COL4A2	Unknown	40195560	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		CPEB4	Unknown	40195560	GWAS catalog	Oocyte meiosis Progesterone-mediated oocyte maturation
		CRP	Unknown	16360360	CTD, Disgenet	Classical antibody-mediated complement activation

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Heart failure

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