Gastric adenoma

Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly +1 more

Ubiquitin mediated proteolysis Endocytosis Influenza A Herpes simplex virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events Transcriptional regulation of granulopoiesis +12 more

DNA replication Base excision repair Nucleotide excision repair Mismatch repair Homologous recombination Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand +19 more

DNA replication Base excision repair Nucleotide excision repair Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex +10 more

Base excision repair

HDR through MMEJ (alt-NHEJ)

RNA polymerase Nucleotide excision repair Huntington disease Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Estrogen-dependent gene expression +25 more

Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence +2 more

Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells +1 more

PPAR signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Osteoclast differentiation Thermogenesis Non-alcoholic fatty liver disease Huntington disease Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Lipid and atherosclerosis PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of PTEN gene transcription +13 more

Receptor-type tyrosine-protein phosphatases

mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle Oocyte meiosis PI3K-Akt signaling pathway AMPK signaling pathway Adrenergic signaling in cardiomyocytes TGF-beta signaling pathway Hippo signaling pathway Tight junction T cell receptor signaling pathway Dopaminergic synapse Long-term depression Chagas disease Hepatitis C Human papillomavirus infection Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +52 more

Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway

Lysine degradation Metabolic pathways Thermogenesis PKMTs methylate histone lysines +1 more

Lysine degradation Metabolic pathways

Regulation of PTEN stability and activity

Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis +4 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Wnt signaling pathway VEGF signaling pathway Focal adhesion Gap junction Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Morphine addiction Leishmaniasis African trypanosomiasis Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer Diabetic cardiomyopathy Disinhibition of SNARE formation Activation of NF-kappaB in B cells Trafficking of GluR2-containing AMPA receptors Depolymerisation of the Nuclear Lamina WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RUNX1 regulates transcription of genes involved in differentiation of myeloid cells +77 more

Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species Sphingolipid de novo biosynthesis +1 more

Spliceosome

cAMP signaling pathway Hedgehog signaling pathway Axon guidance Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Hedgehog 'off' state Ligand-receptor interactions Hedgehog 'on' state Activation of SMO +7 more

SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization +8 more

Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling

Adherens junction Neutrophil degranulation

Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis Salmonella infection Primary immunodeficiency Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation +5 more

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules

EGFR downregulation

Signaling by BRAF and RAF fusions

Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +3 more

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression +4 more

Homologous recombination Non-homologous end-joining Cellular senescence DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +14 more

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +5 more

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes +4 more

Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation +32 more

MAPK signaling pathway Ras signaling pathway Axon guidance Downstream signal transduction EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +5 more

Endocrine resistance Cell cycle Cellular senescence Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry +30 more

Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis Activation of NF-kappaB in B cells +1 more

MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Pathways in cancer Thyroid cancer Non-small cell lung cancer Central carbon metabolism in cancer RAF/MAP kinase cascade RET signaling +6 more

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation +3 more

Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +7 more

Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation

Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation

Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO

cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Vascular smooth muscle contraction TGF-beta signaling pathway Axon guidance Focal adhesion Adherens junction Tight junction Platelet activation Leukocyte transendothelial migration Regulation of actin cytoskeleton Oxytocin signaling pathway Pathogenic Escherichia coli infection Shigellosis Yersinia infection Human cytomegalovirus infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs Neutrophil degranulation +25 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more