Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLONIC NEOPLASMS	MESH:D003110	HES1	Unknown	19147571	CTD	Fanconi anemia pathway Notch signaling pathway Maturity onset diabetes of the young +8 more
		HMGCS2	Unknown	15059925 27816970	CTD	Valine, leucine and isoleucine degradation Butanoate metabolism Terpenoid backbone biosynthesis +4 more
		HNF1B	Unknown	39887605	CTD	Maturity onset diabetes of the young
		HSPA2	Unknown	15059925	CTD	Antigen processing and presentation Lipid and atherosclerosis Regulation of HSF1-mediated heat shock response +2 more
		HSPB1	Unknown	15059925	CTD	MAPK signaling pathway VEGF signaling pathway Amoebiasis +4 more
		ICAM1	Unknown	16497620 7902311	CTD	NF-kappa B signaling pathway Cell adhesion molecules Natural killer cell mediated cytotoxicity +19 more
		ID3	Unknown	15059925	CTD	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription
		IFNG	Unknown	10866311	CTD	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IGF2	Unknown	15057734	CTD	MAPK signaling pathway Ras signaling pathway Hormone signaling +9 more
		IGFBP1	Unknown	15059925	CTD	ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more
		IL1B	Unknown	15059925 18987561 19028472	CTD	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +47 more
		IL1RN	Unknown	18987561	CTD	Cytokine-cytokine receptor interaction Interleukin-10 signaling Interleukin-1 signaling
		IL32	Unknown	25279216	CTD	Cytokine-cytokine receptor interaction Other interleukin signaling
		ITGA7	Unknown	15059925	CTD	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +8 more
		ITIH4	Unknown	25200834	CTD	Platelet degranulation
		JUN	Unknown	12628520 18283038	CTD	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +63 more
		KCNH2	Unknown	16086867	CTD	Voltage gated Potassium channels Phase 3 - rapid repolarisation
		KDM1A	Unknown	25043185	CTD	Thermogenesis HDACs deacetylate histones HDMs demethylate histones +4 more
		KDM5B	Unknown	25043185	CTD	HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors
		KRAS	Unknown	10813127 12800193 12839936 17192441 18372904 19424582	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LEF1	Unknown	21188121	CTD	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LEP	Unknown	17354198	CTD	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		LGR5	Unknown	21188121	CTD	Wnt signaling pathway Regulation of FZD by ubiquitination
		LPL	Unknown	15059925	CTD	Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism +5 more
		LRG1	Unknown	25200834	CTD	Neutrophil degranulation
		LTF	Unknown	12079509	CTD	Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins +2 more
		MACIR	Unknown	30705370	CTD	—
		MAOB	Unknown	15059925	CTD	Glycine, serine and threonine metabolism Arginine and proline metabolism Histidine metabolism +12 more
		MAP2K6	Unknown	15037631	CTD	MAPK signaling pathway Rap1 signaling pathway Cellular senescence +27 more
		MCM2	Unknown	23770000	CTD	DNA replication Cell cycle Activation of ATR in response to replication stress +4 more
		MECOM	Unknown	23770046	CTD	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MEP1A	Unknown	15059925	CTD	Protein digestion and absorption
		MKI67	Unknown	19028472	CTD	—
		MLH1	Unknown	25043185	CTD	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MMP12	Unknown	15059925	CTD	Collagen degradation Degradation of the extracellular matrix
		MMP7	Unknown	15059925	CTD	Wnt signaling pathway Human T-cell leukemia virus 1 infection Collagen degradation +4 more
		MMP9	Unknown	15725655	CTD	Endocrine resistance IL-17 signaling pathway TNF signaling pathway +22 more
		MTHFR	Unknown	16284371	CTD	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		MTOR	Unknown	30705370	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUTYH	Unknown	25030372	CTD	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYC	Unknown	12189186 15059925 18283038 21081470	CTD	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		NDRG2	Unknown	15059925	CTD	—
		NFKB1	Unknown	19028472 20715105	CTD	Antifolate resistance MAPK signaling pathway Ras signaling pathway +96 more
		NOS2	Unknown	16105666 21081470	CTD	Arginine biosynthesis Arginine and proline metabolism Metabolic pathways +21 more
		NOTCH1	Unknown	19147571	CTD	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOX1	Unknown	20715105	CTD	Osteoclast differentiation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease +6 more
		NOX4	Unknown	20715105	CTD	AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease +3 more
		ODC1	Unknown	12810952	CTD	Arginine and proline metabolism Glutathione metabolism Metabolic pathways +3 more
		OXT	Unknown	8647655	CTD	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +3 more
		PARP4	Unknown	16204055	CTD	Base excision repair Apoptosis Nicotinamide salvaging

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Colonic neoplasms

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