Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
breast carcinoma by gene expression profile	MONDO_0006116	PIK3R3	Unknown	30537512	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PIM1	Unknown	30537512	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		PLEC	Unknown	26960396 30531871	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PMS1	Unknown	30205045 30537512	Open Targets	—
		PMS2	Unknown	30537512	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	30537512	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	30062102 30537512	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POT1	Unknown	30531871	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		PPM1D	Unknown	30537512 25850943	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	30537512 30062102 30531871	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PREX2	Unknown	30537512 30375428 25850943	Open Targets	Regulation of PTEN stability and activity
		PRKAR1A	Unknown	30062102	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PSIP1	Unknown	24185510	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	30537512 24185512 29807833	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	30062102 30914635 26527317 32723837 25850943 30531871 29807833 28270497 26563128 27502118 30181556 30537512	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	24185512 29807833 25850943	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPRC	Unknown	30375428	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	30537512	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	32723837	Open Targets	EGFR downregulation
		PTPRT	Unknown	24185510 30537512	Open Targets	—
		QKI	Unknown	27406316	Open Targets	Signaling by BRAF and RAF fusions
		RAD21	Unknown	30537512	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD50	Unknown	30537512 26960396 30531871	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51C	Unknown	30537512 26960396 30531871	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAD51D	Unknown	30062102	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAF1	Unknown	30062102	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RARA	Unknown	27406316	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	30537512	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	24185512 26527317 28580595 25850943 28270497 27502118 30181556 30537512	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	30537512	Open Targets	—
		RBM15	Unknown	30375428	Open Targets	—
		RECQL4	Unknown	30537512	Open Targets	—
		REL	Unknown	30537512	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	30205045 24185512 30062102 30537512 29807833	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGPD3	Unknown	30531871	Open Targets	—
		RHOA	Unknown	29807833 30537512	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RICTOR	Unknown	30537512	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	30537512 30531871	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF43	Unknown	24185510 30537512	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	27406316 25850943	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROS1	Unknown	30537512 25850943	Open Targets	—
		RPN1	Unknown	27406316	Open Targets	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +2 more
		RUNX1T1	Unknown	30531871	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SALL4	Unknown	30531871	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SBDS	Unknown	27406316	Open Targets	Ribosome biogenesis in eukaryotes
		SDHAF2	Unknown	30537512	Open Targets	—
		SDHB	Unknown	30537512	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SEPTIN9	Unknown	32723837	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETD2	Unknown	30531871 30537512 25850943	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	30531871	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more

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Breast carcinoma by gene expression profile

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