Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 10

29 diseases · 69 shared-gene connections
29 Diseases
567 Unique genes
0.077 Avg. similarity score
Leber congenital amaurosis Most-connected disease (14 links)
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Disease Searched: Retinitis pigmentosa 27 Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Leber congenital amaurosis 14 14 73
Cone-rod dystrophy 13 13 76
Macular dystrophy 13 13 49
Optic atrophy 10 10 189
Stargardt disease 10 10 28
Cone dystrophy 9 9 39
Retinitis pigmentosa 8 8 365
Retinopathy 7 7 89
Eye disorders 5 5 29
Retinal degeneration 5 5 40
Retinitis pigmentosa 65 5 5 1
Cone-rod dystrophy 2 4 4 1
Macular dystrophy with central cone involvement 4 4 1
Retinal detachment 4 4 46
X-linked retinitis pigmentosa 4 4 1
Achromatopsia 3 3 7
Nystagmus 3 3 46
Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facies 2 2 1
Leber congenital amaurosis 15 2 2 1
Retinitis pigmentosa 27 2 2 1
Retinitis pigmentosa 9 2 2 1
Spastic paraplegia 15, autosomal recessive 2 2 1
Corneal degeneration 1 1 1
Macular corneal dystrophy 1 1 1
Macular dystrophy with or without cone dysfunction 1 1 1
Multiple mitochondrial dysfunctions syndrome 4 1 1 1
Optic atrophy 11 1 1 1
Uridine-cytidineuria 1 1 1
Yuksel-vogel-bauer syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
CNGB3 10 / 29 Achromatopsia, Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis and 6 more
ABCA4 9 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 5 more
CRB1 9 / 29 Cone dystrophy, Cone-rod dystrophy, Eye disorders, Leber congenital amaurosis and 5 more
RHO 9 / 29 Cone dystrophy, Cone-rod dystrophy, Nystagmus, Optic atrophy and 5 more
CNGA3 8 / 29 Achromatopsia, Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis and 4 more
NMNAT1 8 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Nystagmus and 4 more
PRPH2 8 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 4 more
RDH12 8 / 29 Cone-rod dystrophy, Eye disorders, Leber congenital amaurosis, Macular dystrophy and 4 more
RPGR 8 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 4 more
CDHR1 7 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 3 more
CRX 7 / 29 Cone-rod dystrophy, Cone-rod dystrophy 2, Leber congenital amaurosis, Macular dystrophy and 3 more
EYS 7 / 29 Cone-rod dystrophy, Macular dystrophy, Optic atrophy, Retinal detachment and 3 more
GUCY2D 7 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 3 more
MFSD8 7 / 29 Cone-rod dystrophy, Eye disorders, Macular dystrophy, Macular dystrophy with central cone involvement and 3 more
RPE65 7 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Nystagmus, Retinal degeneration and 3 more
ATF6 6 / 29 Achromatopsia, Cone-rod dystrophy, Macular dystrophy, Nystagmus and 2 more
CACNA1F 6 / 29 Cone dystrophy, Cone-rod dystrophy, Macular dystrophy, Optic atrophy and 2 more
CEP290 6 / 29 Cone-rod dystrophy, Eye disorders, Leber congenital amaurosis, Nystagmus and 2 more
CERKL 6 / 29 Cone dystrophy, Cone-rod dystrophy, Macular dystrophy, Retinitis pigmentosa and 2 more
GPHN 6 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy, Optic atrophy and 2 more
KCNV2 6 / 29 Cone dystrophy, Cone-rod dystrophy, Nystagmus, Optic atrophy and 2 more
PDE6B 6 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 2 more
PDE6C 6 / 29 Achromatopsia, Cone dystrophy, Cone-rod dystrophy, Optic atrophy and 2 more
PROM1 6 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy, Optic atrophy and 2 more
RP2 6 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy, Retinitis pigmentosa and 2 more
RPGRIP1 6 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Nystagmus and 2 more
USH2A 6 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Macular dystrophy and 2 more
AIPL1 5 / 29 Cone-rod dystrophy, Eye disorders, Leber congenital amaurosis, Retinitis pigmentosa and 1 more
CACNA2D4 5 / 29 Cone dystrophy, Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa and 1 more
CFH 5 / 29 Optic atrophy, Retinal degeneration, Retinal detachment, Retinitis pigmentosa and 1 more
CNGA1 5 / 29 Cone-rod dystrophy, Macular dystrophy, Optic atrophy, Retinitis pigmentosa and 1 more
COL2A1 5 / 29 Eye disorders, Optic atrophy, Retinal detachment, Retinitis pigmentosa and 1 more
GUCA1B 5 / 29 Cone dystrophy, Cone-rod dystrophy, Eye disorders, Leber congenital amaurosis and 1 more
LCA5 5 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa, Retinopathy and 1 more
OTX2 5 / 29 Leber congenital amaurosis, Macular dystrophy, Nystagmus, Optic atrophy and 1 more
PCARE 5 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa, Retinopathy and 1 more
RAB28 5 / 29 Cone dystrophy, Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa and 1 more
RP1 5 / 29 Eye disorders, Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa and 1 more
RPGRIP1L 5 / 29 Eye disorders, Leber congenital amaurosis, Optic atrophy, Retinal degeneration and 1 more
ABHD12 4 / 29 Cone dystrophy, Nystagmus, Optic atrophy, Retinitis pigmentosa
AHI1 4 / 29 Leber congenital amaurosis, Optic atrophy, Retinal degeneration, Retinitis pigmentosa
ALMS1 4 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
CABP4 4 / 29 Cone dystrophy, Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa
CFAP410 4 / 29 Cone dystrophy, Cone-rod dystrophy, Leber congenital amaurosis, Retinitis pigmentosa
DRAM2 4 / 29 Cone dystrophy, Cone-rod dystrophy, Macular dystrophy, Retinitis pigmentosa
GNAT2 4 / 29 Achromatopsia, Cone dystrophy, Retinitis pigmentosa, Retinopathy
GRM6 4 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa, Retinopathy
GUCA1A 4 / 29 Cone dystrophy, Cone-rod dystrophy, Macular dystrophy, Retinitis pigmentosa
GUCA1ANB-GUCA1A 4 / 29 Cone dystrophy, Cone-rod dystrophy, Macular dystrophy, Retinitis pigmentosa
LRP5 4 / 29 Eye disorders, Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
MERTK 4 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa, Retinopathy
MKS1 4 / 29 Leber congenital amaurosis, Nystagmus, Optic atrophy, Retinitis pigmentosa
NDP 4 / 29 Eye disorders, Nystagmus, Retinal detachment, Retinitis pigmentosa
NR2E3 4 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
OPA1 4 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa, Stargardt disease
PANK2 4 / 29 Cone-rod dystrophy, Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
RDH5 4 / 29 Optic atrophy, Retinal detachment, Retinitis pigmentosa, Retinopathy
RLBP1 4 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa, Retinopathy
SCLT1 4 / 29 Cone-rod dystrophy, Nystagmus, Optic atrophy, Retinitis pigmentosa
SEMA4A 4 / 29 Cone-rod dystrophy, Eye disorders, Optic atrophy, Retinitis pigmentosa
SPATA7 4 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa, Stargardt disease
TOPORS 4 / 29 Macular dystrophy, Optic atrophy, Retinitis pigmentosa, Retinopathy
TTLL5 4 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa, Retinopathy
TULP1 4 / 29 Leber congenital amaurosis, Leber congenital amaurosis 15, Retinitis pigmentosa, Stargardt disease
WDR19 4 / 29 Cone dystrophy, Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
ZFYVE26 4 / 29 Leber congenital amaurosis, Macular dystrophy, Retinitis pigmentosa, Spastic paraplegia 15, autosomal recessive
ACO2 3 / 29 Optic atrophy, Retinal degeneration, Retinitis pigmentosa
ADAM9 3 / 29 Cone-rod dystrophy, Retinitis pigmentosa, Retinopathy
ARL3 3 / 29 Cone dystrophy, Cone-rod dystrophy, Retinitis pigmentosa
ARL6 3 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa
BEST1 3 / 29 Macular dystrophy, Retinitis pigmentosa, Stargardt disease
C1QTNF5 3 / 29 Optic atrophy, Retinal degeneration, Retinitis pigmentosa
CEP78 3 / 29 Cone-rod dystrophy, Optic atrophy, Retinitis pigmentosa
CNGB1 3 / 29 Optic atrophy, Retinitis pigmentosa, Retinopathy
COL18A1 3 / 29 Macular dystrophy, Nystagmus, Retinitis pigmentosa
COL22A1 3 / 29 Retinal degeneration, Retinal detachment, Retinopathy
DTHD1 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
EFEMP1 3 / 29 Macular dystrophy, Optic atrophy, Retinitis pigmentosa
ELOVL1 3 / 29 Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facies, Optic atrophy, Retinitis pigmentosa
GPR179 3 / 29 Optic atrophy, Retinitis pigmentosa, Retinopathy
IDH3B 3 / 29 Optic atrophy, Retinitis pigmentosa, Retinopathy
IFT140 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
IMPDH1 3 / 29 Leber congenital amaurosis, Retinitis pigmentosa, Retinopathy
IMPG1 3 / 29 Cone-rod dystrophy, Macular dystrophy, Retinitis pigmentosa
IMPG2 3 / 29 Cone-rod dystrophy, Macular dystrophy, Retinitis pigmentosa
INPP5E 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
LRAT 3 / 29 Leber congenital amaurosis, Retinitis pigmentosa, Stargardt disease
LRIT3 3 / 29 Optic atrophy, Retinitis pigmentosa, Stargardt disease
MAK 3 / 29 Eye disorders, Retinitis pigmentosa, Retinopathy
MYO7A 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
NBAS 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
NPHP1 3 / 29 Eye disorders, Leber congenital amaurosis, Retinitis pigmentosa
NPHP3 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
NPHP4 3 / 29 Leber congenital amaurosis, Optic atrophy, Retinitis pigmentosa
NRL 3 / 29 Retinal degeneration, Retinitis pigmentosa, Retinitis pigmentosa 27
PCDH15 3 / 29 Cone dystrophy, Optic atrophy, Retinitis pigmentosa
PDE6A 3 / 29 Leber congenital amaurosis, Retinitis pigmentosa, Retinopathy
PDE6H 3 / 29 Achromatopsia, Cone dystrophy, Retinitis pigmentosa
PITPNM3 3 / 29 Cone dystrophy, Cone-rod dystrophy, Retinitis pigmentosa
PRPF31 3 / 29 Leber congenital amaurosis, Retinitis pigmentosa, Retinopathy
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Phototransduction
GNAT2, GUCY2D, CNGB1, PDE6A, PDE6B, RHO, GUCA1A, SAG, GUCA1ANB-GUCA1A, GUCA1B, CNGA1, RGS9
 KEGG 17 / 29 12.4× 6.96e-16 2.49e-13 ✓ sig.
BBSome-mediated cargo-targeting to cilium
ARL6, BBS2, BBS5, CCT2, TTC8, BBS10, BBS7, BBS9, MKKS, BBS1, BBS12, BBS4
 Reactome 14 / 23 12.9× 1.29e-13 2.93e-11 ✓ sig.
The canonical retinoid cycle in rods (twilight vision)
ABCA4, LRAT, RPE65, RBP3, RHO, RLBP1, RDH12, MYO7A, RBP1, CYP4V2, RDH11, RDH5
 Reactome 13 / 20 13.8× 2.89e-13 6.08e-11 ✓ sig.
Inactivation, recovery and regulation of the phototransduction cascade
GUCY2D, CNGB1, PDE6A, PDE6B, RHO, GUCA1A, SAG, GUCA1B, CNGA1, RGS9, GNAT1, PDE6G
 Reactome 14 / 33 9.0× 8.32e-11 9.97e-9 ✓ sig.
Activation of the phototransduction cascade
CNGB1, PDE6A, PDE6B, RHO, CNGA1, GNB1, GNAT1, PDE6G
 Reactome 8 / 9 18.8× 2.03e-10 2.20e-8 ✓ sig.
Retinoid cycle disease events
ABCA4, LRAT, RLBP1, OPN1MW, RDH12, RBP1, RDH5, OPN1SW, RBP4
 Reactome 9 / 13 14.7× 6.61e-10 6.43e-8 ✓ sig.
Anchoring of the basal body to the plasma membrane
ALMS1, CEP290, CEP78, SCLT1, RPGRIP1L, AHI1, IQCB1, NPHP1, NPHP4, TUBB4B, MKS1, TMEM67
 Reactome 22 / 98 4.8× 6.91e-10 6.66e-8 ✓ sig.
Intraflagellar transport
DYNC2H1, WDR19, IFT81, CLUAP1, IFT140, TUBB4B, IFT172, IFT27, IFT74, KIF3B, TUBB6, IFT80
 Reactome 15 / 54 5.9× 1.68e-8 1.17e-6 ✓ sig.
Collagen biosynthesis and modifying enzymes
COL2A1, COL18A1, COL9A1, COL22A1, COL9A3, CRTAP, P3H2, COL11A1, COL9A2, P4HA2, COL4A2, COL4A4
 Reactome 13 / 67 4.1× 1.22e-5 3.43e-4 ✓ sig.
Recruitment of mitotic centrosome proteins and complexes
ALMS1, CEP290, CEP78, TUBB4B, CEP250, PLK4, TUBGCP4, TUBGCP6, NEK2, OFD1, CEP164, CEP41
 Reactome 14 / 82 3.6× 2.63e-5 6.53e-4 ✓ sig.
Recruitment of NuMA to mitotic centrosomes
ALMS1, CEP290, CEP78, TUBB4B, CEP250, PLK4, TUBB6, TUBGCP4, TUBGCP6, NEK2, OFD1, CEP164
 Reactome 15 / 94 3.4× 3.13e-5 7.52e-4 ✓ sig.
Hedgehog 'off' state
DYNC2H1, WDR19, RPGRIP1L, IFT140, TUBB4B, MKS1, KIF7, IFT172, TUBB6, IFT88, OFD1
 Reactome 11 / 56 4.2× 5.05e-5 1.10e-3 ✓ sig.
Loss of Nlp from mitotic centrosomes
ALMS1, CEP290, CEP78, TUBB4B, CEP250, PLK4, NEK2, OFD1, CEP164, CEP41, SDCCAG8, CEP76
 Reactome 12 / 70 3.6× 9.43e-5 1.81e-3 ✓ sig.
Loss of proteins required for interphase microtubule organization from the centrosome
ALMS1, CEP290, CEP78, TUBB4B, CEP250, PLK4, NEK2, OFD1, CEP164, CEP41, SDCCAG8, CEP76
 Reactome 12 / 70 3.6× 9.43e-5 1.81e-3 ✓ sig.
AURKA Activation by TPX2
ALMS1, CEP290, CEP78, TUBB4B, CEP250, PLK4, NEK2, OFD1, CEP164, CEP41, SDCCAG8, CEP76
 Reactome 12 / 73 3.5× 1.43e-4 2.52e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
visual perception
ABCA4, ATF6, CNGA3, CNGB3, GNAT2, PDE6C, PDE6H, AIPL1, CRB1, CRX, GUCY2D, LRAT
 GO:0007601 116 / 215 17.8× 4.91e-120 1.87e-114 ✓ sig.
photoreceptor cell maintenance
ABCA4, CRB1, LCA5, PROM1, RP1, TULP1, BBS2, CNGB1, RHO, RP1L1, SPATA7, USH2A
 GO:0045494 35 / 45 25.6× 6.34e-45 1.05e-40 ✓ sig.
retina development in camera-type eye
CNGA3, CRB1, CRX, RP1, RPGRIP1, TULP1, MERTK, NR2E3, PDE6A, PDE6B, RHO, RP1L1
 GO:0060041 40 / 85 15.5× 4.00e-38 4.22e-34 ✓ sig.
cilium assembly
ARL6, BBS2, DYNC2H1, FAM161A, BBS5, CFAP410, RPGR, WDR19, POC1B, CEP290, IFT81, RP2
 GO:0060271 57 / 237 7.9× 4.69e-35 3.64e-31 ✓ sig.
cell projection organization
RP1, ARL6, BBS2, DYNC2H1, FAM161A, RP1L1, BBS5, CFAP410, RPGR, WDR19, POC1B, CEP290
 GO:0030030 45 / 214 6.9× 3.29e-25 1.07e-21 ✓ sig.
detection of light stimulus involved in visual perception
GNAT2, CRB1, TULP1, RPE65, CNGB1, EYS, REEP6, CACNA2D4, PRPH2, CACNA1F, GRM6, BEST1
 GO:0050908 17 / 24 23.3× 3.52e-21 6.86e-18 ✓ sig.
non-motile cilium assembly
RPGRIP1, BBS2, DYNC2H1, CEP290, RPGRIP1L, IFT140, NPHP3, TTC8, MKS1, MAK, BBS10, BBS7
 GO:1905515 23 / 57 13.3× 1.60e-20 2.73e-17 ✓ sig.
photoreceptor cell outer segment organization
CRB1, RP1, CNGB1, PCARE, RP1L1, CDHR1, PRPH2, AHI1, IFT140, NPHP4, ROM1, TOPORS
 GO:0035845 13 / 15 28.6× 1.60e-18 2.03e-15 ✓ sig.
sensory perception of light stimulus
PDE6C, RHO, USH2A, GRM6, MYO7A, ADGRV1, CDH23, CLRN1, PCDH15, USH1C, USH1G, WHRN
 GO:0050953 12 / 13 30.4× 6.87e-18 8.15e-15 ✓ sig.
retina homeostasis
AIPL1, TULP1, RPE65, CNGB1, POC1B, CDH3, WHRN, SOD1, BBS1, BBS4, CRB2, ARMS2
 GO:0001895 12 / 15 26.4× 2.27e-16 2.06e-13 ✓ sig.
intraciliary transport
LCA5, RPGR, IFT81, IFT140, MAK, IFT172, IFT27, IFT74, KIF3B, WDPCP, ARL3, BBS12
 GO:0042073 15 / 36 13.7× 4.38e-14 2.68e-11 ✓ sig.
eye photoreceptor cell development
CRB1, RPGRIP1, TULP1, NR2E3, RPGR, CEP290, FSCN2, MYO7A, PAX6, MFRP, POC5, GNAT1
 GO:0042462 12 / 21 18.8× 1.24e-13 7.02e-11 ✓ sig.
retina layer formation
CRB1, PROM1, ARL6, AHI1, TOPORS, NDP, TFAP2A, TSPAN12, SLC1A1, FAT3, LARGE1, RS1
 GO:0010842 12 / 27 14.6× 6.23e-12 2.48e-9 ✓ sig.
phototransduction
GNAT2, CNGB1, NR2E3, RHO, CABP4, GUCA1A, RGR, GUCA1B, OPN1LW, OPN1MW, UNC119, GNAT1
 GO:0007602 13 / 34 12.6× 8.34e-12 3.24e-9 ✓ sig.
kidney development
DYNC2H1, CEP290, RPGRIP1L, NPHP3, WT1, TFAP2A, CC2D2A, IFT27, INVS, WDPCP, WFS1, ARL3
 GO:0001822 24 / 146 5.4× 1.39e-11 5.16e-9 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Optic atrophy Retinitis pigmentosa 0.344 142 7.43e-201 5.12e-199 ✓ sig.
Cone-rod dystrophy Retinitis pigmentosa 0.179 67 1.90e-101 8.01e-100 ✓ sig.
Leber congenital amaurosis Retinitis pigmentosa 0.174 65 4.83e-99 2.01e-97 ✓ sig.
Macular dystrophy Retinitis pigmentosa 0.110 41 7.17e-60 2.15e-58 ✓ sig.
Cone dystrophy Cone-rod dystrophy 0.303 27 8.86e-56 2.54e-54 ✓ sig.
Cone-rod dystrophy Optic atrophy 0.172 39 1.72e-55 4.91e-54 ✓ sig.
Leber congenital amaurosis Optic atrophy 0.164 37 2.34e-52 6.44e-51 ✓ sig.
Cone-rod dystrophy Macular dystrophy 0.273 27 1.09e-51 2.99e-50 ✓ sig.
Retinitis pigmentosa Retinopathy 0.112 46 1.52e-51 4.16e-50 ✓ sig.
Cone-rod dystrophy Leber congenital amaurosis 0.210 26 2.69e-43 6.59e-42 ✓ sig.
Cone dystrophy Optic atrophy 0.112 23 7.84e-35 1.70e-33 ✓ sig.
Cone-rod dystrophy Retinopathy 0.161 23 1.81e-34 3.88e-33 ✓ sig.
Optic atrophy Retinopathy 0.112 28 1.89e-32 3.92e-31 ✓ sig.
Cone-rod dystrophy Stargardt disease 0.180 16 6.06e-31 1.21e-29 ✓ sig.
Leber congenital amaurosis Macular dystrophy 0.171 18 1.41e-30 2.79e-29 ✓ sig.
Cone dystrophy Macular dystrophy 0.203 15 7.01e-29 1.34e-27 ✓ sig.
Cone dystrophy Leber congenital amaurosis 0.153 15 6.25e-26 1.09e-24 ✓ sig.
Leber congenital amaurosis Stargardt disease 0.146 13 6.49e-24 1.07e-22 ✓ sig.
Macular dystrophy Stargardt disease 0.182 12 6.84e-24 1.13e-22 ✓ sig.
Cone dystrophy Retinopathy 0.112 13 2.15e-20 3.19e-19 ✓ sig.
Eye disorders Leber congenital amaurosis 0.096 9 6.40e-15 7.70e-14 ✓ sig.
Cone-rod dystrophy Nystagmus 0.089 10 1.55e-14 1.83e-13 ✓ sig.
Retinal detachment Retinopathy 0.079 10 8.03e-14 9.13e-13 ✓ sig.
Cone-rod dystrophy Retinal degeneration 0.083 9 2.45e-13 2.73e-12 ✓ sig.
Cone dystrophy Stargardt disease 0.115 7 4.14e-13 4.57e-12 ✓ sig.
Achromatopsia Cone dystrophy 0.119 5 1.62e-12 1.71e-11 ✓ sig.
Leber congenital amaurosis Retinal degeneration 0.075 8 1.12e-11 1.13e-10 ✓ sig.
Cone dystrophy Nystagmus 0.089 7 1.81e-11 1.80e-10 ✓ sig.
Leber congenital amaurosis Nystagmus 0.071 8 3.71e-11 3.60e-10 ✓ sig.
Cone-rod dystrophy Eye disorders 0.071 7 7.39e-11 6.99e-10 ✓ sig.
Achromatopsia Retinopathy 0.054 5 1.16e-10 1.09e-9 ✓ sig.
Retinal detachment Stargardt disease 0.071 5 1.73e-8 1.34e-7 ✓ sig.
Eye disorders Stargardt disease 0.074 4 1.97e-7 1.32e-6 ✓ sig.
Achromatopsia Macular dystrophy 0.056 3 1.03e-6 6.29e-6 ✓ sig.
Eye disorders Retinal detachment 0.041 3 8.49e-5 2.60e-4 ✓ sig.
Macular dystrophy with central cone involvement Stargardt disease 0.034 1 1.81e-3 2.49e-3 ✓ sig.
Cone-rod dystrophy 2 Stargardt disease 0.034 1 1.81e-3 2.49e-3 ✓ sig.
Leber congenital amaurosis 15 Stargardt disease 0.034 1 1.81e-3 2.49e-3 ✓ sig.
Corneal degeneration Stargardt disease 0.034 1 1.81e-3 2.49e-3 ✓ sig.
Eye disorders Macular dystrophy with central cone involvement 0.033 1 1.87e-3 2.57e-3 ✓ sig.
Cone dystrophy Retinitis pigmentosa 65 0.025 1 2.52e-3 3.27e-3 ✓ sig.
Retinal degeneration Uridine-cytidineuria 0.024 1 2.58e-3 3.34e-3 ✓ sig.
Cone-rod dystrophy 2 Retinal degeneration 0.024 1 2.58e-3 3.34e-3 ✓ sig.
Retinal degeneration Retinitis pigmentosa 27 0.024 1 2.58e-3 3.34e-3 ✓ sig.
Retinal detachment Yuksel-vogel-bauer syndrome 0.021 1 2.97e-3 3.79e-3 ✓ sig.
Macular dystrophy Retinitis pigmentosa 65 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Macular dystrophy X-linked retinitis pigmentosa 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Macular dystrophy Spastic paraplegia 15, autosomal recessive 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Cone-rod dystrophy 2 Macular dystrophy 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Macular dystrophy Macular dystrophy with or without cone dysfunction 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Macular dystrophy Macular dystrophy with central cone involvement 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Macular corneal dystrophy Macular dystrophy 0.020 1 3.16e-3 4.00e-3 ✓ sig.
Leber congenital amaurosis Leber congenital amaurosis 15 0.014 1 4.71e-3 5.69e-3 ✓ sig.
Leber congenital amaurosis X-linked retinitis pigmentosa 0.014 1 4.71e-3 5.69e-3 ✓ sig.
Leber congenital amaurosis Spastic paraplegia 15, autosomal recessive 0.014 1 4.71e-3 5.69e-3 ✓ sig.
Cone-rod dystrophy 2 Leber congenital amaurosis 0.014 1 4.71e-3 5.69e-3 ✓ sig.
Leber congenital amaurosis Retinitis pigmentosa 65 0.014 1 4.71e-3 5.69e-3 ✓ sig.
Cone-rod dystrophy Retinitis pigmentosa 65 0.013 1 4.91e-3 5.89e-3 ✓ sig.
Cone-rod dystrophy Macular dystrophy with central cone involvement 0.013 1 4.91e-3 5.89e-3 ✓ sig.
Cone-rod dystrophy X-linked retinitis pigmentosa 0.013 1 4.91e-3 5.89e-3 ✓ sig.
Retinopathy X-linked retinitis pigmentosa 0.011 1 5.75e-3 6.78e-3 ✓ sig.
Optic atrophy Retinitis pigmentosa 9 0.005 1 1.22e-2 1.35e-2 ✓ sig.
Optic atrophy Retinitis pigmentosa 65 0.005 1 1.22e-2 1.35e-2 ✓ sig.
Optic atrophy Optic atrophy 11 0.005 1 1.22e-2 1.35e-2 ✓ sig.
Multiple mitochondrial dysfunctions syndrome 4 Optic atrophy 0.005 1 1.22e-2 1.35e-2 ✓ sig.
Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facies Optic atrophy 0.005 1 1.22e-2 1.35e-2 ✓ sig.
Retinitis pigmentosa Retinitis pigmentosa 9 0.003 1 2.36e-2 2.52e-2 ✓ sig.
Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facies Retinitis pigmentosa 0.003 1 2.36e-2 2.52e-2 ✓ sig.
Retinitis pigmentosa Retinitis pigmentosa 27 0.003 1 2.36e-2 2.52e-2 ✓ sig.