Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 82

12 diseases · 22 shared-gene connections
12 Diseases
12 Unique genes
0.248 Avg. similarity score
Growth hormone-secreting pituitary adenoma Most-connected disease (8 links)
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Disease Searched: Growth hormone-secreting pituitary adenoma Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Growth hormone-secreting pituitary adenoma 8 8 5
Acromegaly 5 5 2
Pituitary neoplasms 5 5 6
Ateleiotic dwarfism 4 4 1
Congenital isolated growth hormone deficiency 4 4 2
Isolated somatotropin deficiency 4 4 1
Pituitary gigantism 4 4 2
Chromosome xq26.3 duplication syndrome 3 3 1
X-linked acrogigantism due to xq26 microduplication 3 3 1
Pituitary adenoma 2 2 2
multiple endocrine neoplasia type 1 1 1 1
multiple endocrine neoplasia type 4 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
GH1 5 / 12 Ateleiotic dwarfism, Congenital isolated growth hormone deficiency, Growth hormone-secreting pituitary adenoma, Isolated somatotropin deficiency and 1 more
AIP 4 / 12 Acromegaly, Growth hormone-secreting pituitary adenoma, Pituitary adenoma, Pituitary gigantism
GPR101 4 / 12 Acromegaly, Chromosome xq26.3 duplication syndrome, Growth hormone-secreting pituitary adenoma, X-linked acrogigantism due to xq26 microduplication
CDKN1B 2 / 12 multiple endocrine neoplasia type 4, Pituitary neoplasms
MEN1 2 / 12 multiple endocrine neoplasia type 1, Pituitary gigantism
PRL 2 / 12 Growth hormone-secreting pituitary adenoma, Pituitary neoplasms
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Hormone signaling
GH1, GHRHR, GNAS, PRL, AGTR1, DRD2, IGF1
 KEGG 7 / 219 32.0× 4.47e-10 5.65e-8 ✓ sig.
Cushing syndrome
AIP, GNAS, MEN1, AGTR1, CDKN1B
 KEGG 5 / 155 32.3× 2.47e-7 1.54e-5 ✓ sig.
Growth hormone synthesis, secretion and action
GH1, GHRHR, GNAS, IGF1
 KEGG 4 / 122 32.8× 4.71e-6 1.94e-4 ✓ sig.
Neuroactive ligand-receptor interaction
GH1, GHRHR, PRL, AGTR1, DRD2
 KEGG 5 / 370 13.5× 1.79e-5 5.73e-4 ✓ sig.
Prolactin receptor signaling
GH1, PRL
 Reactome 2 / 12 167× 6.01e-5 1.55e-3 ✓ sig.
Growth hormone receptor signaling
GH1, PRL
 Reactome 2 / 14 143× 8.27e-5 2.00e-3 ✓ sig.
Endocrine resistance
GNAS, CDKN1B, IGF1
 KEGG 3 / 99 30.3× 1.13e-4 2.56e-3 ✓ sig.
Synthesis, secretion, and deacylation of Ghrelin
GH1, IGF1
 Reactome 2 / 19 105× 1.55e-4 3.28e-3 ✓ sig.
PI3K-Akt signaling pathway
GH1, PRL, CDKN1B, IGF1
 KEGG 4 / 361 11.1× 3.28e-4 5.94e-3 ✓ sig.
Glucagon-type ligand receptors
GHRHR, GNAS
 Reactome 2 / 33 60.7× 4.75e-4 7.97e-3 ✓ sig.
Transcriptional misregulation in cancer
MEN1, CDKN1B, IGF1
 KEGG 3 / 198 15.2× 8.70e-4 1.26e-2 ✓ sig.
Rap1 signaling pathway
GNAS, DRD2, IGF1
 KEGG 3 / 211 14.2× 1.05e-3 1.46e-2 ✓ sig.
Cocaine addiction
GNAS, DRD2
 KEGG 2 / 49 40.9× 1.05e-3 1.46e-2 ✓ sig.
Ovarian steroidogenesis
GNAS, IGF1
 KEGG 2 / 52 38.5× 1.18e-3 1.59e-2 ✓ sig.
Pathways in cancer
GNAS, AGTR1, CDKN1B, IGF1
 KEGG 4 / 533 7.5× 1.43e-3 1.85e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of insulin-like growth factor receptor signaling pathway
GH1, GHRHR, IGF1
 GO:0043568 3 / 13 359× 5.77e-8 7.67e-6 ✓ sig.
positive regulation of multicellular organism growth
GH1, GHRHR, DRD2
 GO:0040018 3 / 34 137× 1.20e-6 9.82e-5 ✓ sig.
mammary gland development
GHRHR, PRL, IGF1
 GO:0030879 3 / 37 126× 1.55e-6 1.22e-4 ✓ sig.
inner ear development
CDH23, CDKN1B, IGF1
 GO:0048839 3 / 54 86.5× 4.93e-6 3.05e-4 ✓ sig.
positive regulation of growth hormone secretion
GHRHR, DRD2
 GO:0060124 2 / 9 346× 1.36e-5 6.87e-4 ✓ sig.
negative regulation of cyclin-dependent protein serine/threonine kinase activity
MEN1, CDKN1B
 GO:0045736 2 / 9 346× 1.36e-5 6.87e-4 ✓ sig.
adenohypophysis development
GHRHR, DRD2
 GO:0021984 2 / 9 346× 1.36e-5 6.87e-4 ✓ sig.
adenylate cyclase-activating adrenergic receptor signaling pathway
GPR101, GNAS
 GO:0071880 2 / 14 222× 3.43e-5 1.40e-3 ✓ sig.
growth hormone receptor signaling pathway
GH1, IGF1
 GO:0060396 2 / 16 195× 4.51e-5 1.72e-3 ✓ sig.
regulation of protein metabolic process
GHRHR, IGF1
 GO:0051246 2 / 24 130× 1.04e-4 3.21e-3 ✓ sig.
postsynaptic modulation of chemical synaptic transmission
DRD2, IGF1
 GO:0099170 2 / 25 125× 1.12e-4 3.41e-3 ✓ sig.
positive regulation of receptor internalization
GH1, DRD2
 GO:0002092 2 / 26 120× 1.22e-4 3.61e-3 ✓ sig.
negative regulation of cell population proliferation
MEN1, CDKN1B, DRD2, IGF1
 GO:0008285 4 / 444 14.0× 1.34e-4 3.87e-3 ✓ sig.
cell surface receptor signaling pathway via STAT
GH1, IGF1
 GO:0097696 2 / 28 111× 1.42e-4 4.04e-3 ✓ sig.
G protein-coupled receptor signaling pathway
GPR101, GHRHR, GNAS, AGTR1, DRD2
 GO:0007186 5 / 1,031 7.6× 2.89e-4 6.78e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Acromegaly Growth hormone-secreting pituitary adenoma 0.333 2 8.44e-8 5.94e-7 ✓ sig.
Growth hormone-secreting pituitary adenoma Pituitary neoplasms 0.200 2 1.26e-6 7.29e-6 ✓ sig.
Ateleiotic dwarfism Isolated somatotropin deficiency 0.500 1 6.49e-5 2.33e-4 ✓ sig.
Chromosome xq26.3 duplication syndrome X-linked acrogigantism due to xq26 microduplication 0.500 1 6.49e-5 2.33e-4 ✓ sig.
Acromegaly Chromosome xq26.3 duplication syndrome 0.333 1 1.30e-4 3.93e-4 ✓ sig.
multiple endocrine neoplasia type 1 Pituitary gigantism 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Congenital isolated growth hormone deficiency Isolated somatotropin deficiency 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Ateleiotic dwarfism Congenital isolated growth hormone deficiency 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Acromegaly X-linked acrogigantism due to xq26 microduplication 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Acromegaly Pituitary gigantism 0.250 1 2.60e-4 6.51e-4 ✓ sig.
Acromegaly Pituitary adenoma 0.250 1 2.60e-4 6.51e-4 ✓ sig.
Pituitary adenoma Pituitary gigantism 0.250 1 2.60e-4 6.51e-4 ✓ sig.
Ateleiotic dwarfism Growth hormone-secreting pituitary adenoma 0.167 1 3.25e-4 7.71e-4 ✓ sig.
Chromosome xq26.3 duplication syndrome Growth hormone-secreting pituitary adenoma 0.167 1 3.25e-4 7.71e-4 ✓ sig.
Growth hormone-secreting pituitary adenoma X-linked acrogigantism due to xq26 microduplication 0.167 1 3.25e-4 7.71e-4 ✓ sig.
Growth hormone-secreting pituitary adenoma Isolated somatotropin deficiency 0.167 1 3.25e-4 7.71e-4 ✓ sig.
Ateleiotic dwarfism Pituitary neoplasms 0.143 1 3.90e-4 8.67e-4 ✓ sig.
Isolated somatotropin deficiency Pituitary neoplasms 0.143 1 3.90e-4 8.67e-4 ✓ sig.
multiple endocrine neoplasia type 4 Pituitary neoplasms 0.143 1 3.90e-4 8.67e-4 ✓ sig.
Congenital isolated growth hormone deficiency Growth hormone-secreting pituitary adenoma 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Growth hormone-secreting pituitary adenoma Pituitary gigantism 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Congenital isolated growth hormone deficiency Pituitary neoplasms 0.125 1 7.79e-4 1.41e-3 ✓ sig.