Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 87

12 diseases · 21 shared-gene connections
12 Diseases
84 Unique genes
0.129 Avg. similarity score
Antisocial personality disorder Most-connected disease (7 links)
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Disease Searched: Conduct disorder Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Antisocial personality disorder 7 7 4
Colchicine resistance 6 6 1
Familial mediterranean fever 6 6 2
Orthostatic hypotension 5 5 3
Congenital dyserythropoietic anemia 4 4 10
Conduct disorder 3 3 52
Hematologic neoplasms 3 3 5
Hyperpituitarism 3 3 15
Separation anxiety disorder 2 2 1
Brunner syndrome 1 1 1
Dopamine beta-hydroxy­lase deficiency 1 1 2
severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
ABCB1 7 / 12 Antisocial personality disorder, Colchicine resistance, Congenital dyserythropoietic anemia, Familial mediterranean fever and 3 more
DRD4 3 / 12 Antisocial personality disorder, Conduct disorder, Separation anxiety disorder
GATAD2B 2 / 12 Conduct disorder, severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
HSPA5 2 / 12 Dopamine beta-hydroxy­lase deficiency, Hematologic neoplasms
HTR1B 2 / 12 Antisocial personality disorder, Conduct disorder
MAD1L1 2 / 12 Conduct disorder, Hyperpituitarism
MAOA 2 / 12 Antisocial personality disorder, Brunner syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Tyrosine metabolism
MAOA, ADH1B, ADH1C, DBH
 KEGG 4 / 36 15.9× 1.11e-4 2.37e-3 ✓ sig.
Ethanol oxidation
ADH1B, ADH1C
 Reactome 2 / 12 23.8× 3.05e-3 3.09e-2 ✓ sig.
Fatty acid degradation
ADH1B, ADH1C, GCDH
 KEGG 3 / 43 10.0× 3.33e-3 3.29e-2 ✓ sig.
Defective MAOA causes Brunner syndrome (BRUNS)
MAOA
 Reactome 1 / 1 143× 6.99e-3 5.47e-2
Receptor-type tyrosine-protein phosphatases
PTPRD, PTPRF
 Reactome 2 / 20 14.3× 8.46e-3 6.23e-2
Synaptic adhesion-like molecules
PTPRD, PTPRF
 Reactome 2 / 21 13.6× 9.31e-3 6.62e-2
Enzymatic degradation of Dopamine by monoamine oxidase
MAOA
 Reactome 1 / 2 71.5× 1.39e-2 8.48e-2
Metabolism of serotonin
MAOA
 Reactome 1 / 2 71.5× 1.39e-2 8.48e-2
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
MAOA
 Reactome 1 / 2 71.5× 1.39e-2 8.48e-2
NOTCH4 Activation and Transmission of Signal to the Nucleus
YWHAZ
 Reactome 1 / 2 71.5× 1.39e-2 8.48e-2
Drug metabolism - cytochrome P450
MAOA, ADH1B, ADH1C
 KEGG 3 / 73 5.9× 1.44e-2 8.68e-2
Mitotic Telophase/Cytokinesis
KIF23
 Reactome 1 / 3 47.7× 2.08e-2 1.07e-1
Enzymatic degradation of dopamine by COMT
MAOA
 Reactome 1 / 3 47.7× 2.08e-2 1.07e-1
IRE1alpha activates chaperones
HSPA5
 Reactome 1 / 3 47.7× 2.08e-2 1.07e-1
RUNX2 regulates osteoblast differentiation
AR
 Reactome 1 / 3 47.7× 2.08e-2 1.07e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
DRD4, HTR1B, CNR1, OPRD1, OPRM1
 GO:0007187 5 / 54 20.6× 4.33e-6 2.69e-4 ✓ sig.
behavioral response to ethanol
DRD4, DBH, OPRM1
 GO:0048149 3 / 10 66.7× 1.03e-5 5.37e-4 ✓ sig.
regulation of chloride transport
ABCB1, ATP8B1
 GO:2001225 2 / 4 111× 1.19e-4 3.45e-3 ✓ sig.
erythrocyte differentiation
CDIN1, RACGAP1, KLF1, MFHAS1
 GO:0030218 4 / 65 13.7× 2.09e-4 5.22e-3 ✓ sig.
cellular response to alkaloid
ABCB1, HTR1B
 GO:0071312 2 / 6 74.2× 2.96e-4 6.69e-3 ✓ sig.
cell surface receptor protein tyrosine phosphatase signaling pathway
PTPRD, PTPRF
 GO:0007185 2 / 7 63.6× 4.13e-4 8.45e-3 ✓ sig.
fear response
DRD4, DBH
 GO:0042596 2 / 8 55.6× 5.49e-4 1.03e-2 ✓ sig.
chemical synaptic transmission
DRD4, HTR1B, ACP1, RIT2, SLC6A1, DBH
 GO:0007268 6 / 236 5.7× 6.81e-4 1.19e-2 ✓ sig.
G protein-coupled opioid receptor signaling pathway
OPRD1, OPRM1
 GO:0038003 2 / 9 49.4× 7.04e-4 1.21e-2 ✓ sig.
negative regulation of cytosolic calcium ion concentration
KCNA5, OPRM1
 GO:0051481 2 / 11 40.4× 1.07e-3 1.58e-2 ✓ sig.
mitotic spindle midzone assembly
KIF23, RACGAP1
 GO:0051256 2 / 11 40.4× 1.07e-3 1.58e-2 ✓ sig.
dopamine catabolic process
MAOA, DBH
 GO:0042420 2 / 11 40.4× 1.07e-3 1.58e-2 ✓ sig.
cerebellar Purkinje cell layer development
HSPA5, FAIM2
 GO:0021680 2 / 12 37.1× 1.28e-3 1.76e-2 ✓ sig.
maternal behavior
DBH, BRINP1
 GO:0042711 2 / 14 31.8× 1.75e-3 2.14e-2 ✓ sig.
detection of mechanical stimulus
PKD1L2, PKD1L3
 GO:0050982 2 / 15 29.7× 2.02e-3 2.31e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Antisocial personality disorder Conduct disorder 0.036 2 6.68e-5 2.39e-4 ✓ sig.
Colchicine resistance Familial mediterranean fever 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Colchicine resistance Orthostatic hypotension 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Antisocial personality disorder Separation anxiety disorder 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Antisocial personality disorder Colchicine resistance 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Antisocial personality disorder Brunner syndrome 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Colchicine resistance Hematologic neoplasms 0.167 1 3.25e-4 7.70e-4 ✓ sig.
Familial mediterranean fever Orthostatic hypotension 0.200 1 3.90e-4 8.66e-4 ✓ sig.
Antisocial personality disorder Familial mediterranean fever 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Familial mediterranean fever Hematologic neoplasms 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Dopamine beta-hydroxy­lase deficiency Hematologic neoplasms 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Colchicine resistance Congenital dyserythropoietic anemia 0.091 1 6.49e-4 1.24e-3 ✓ sig.
Antisocial personality disorder Orthostatic hypotension 0.143 1 7.79e-4 1.40e-3 ✓ sig.
Colchicine resistance Hyperpituitarism 0.063 1 9.74e-4 1.66e-3 ✓ sig.
Congenital dyserythropoietic anemia Familial mediterranean fever 0.083 1 1.30e-3 2.06e-3 ✓ sig.
Congenital dyserythropoietic anemia Orthostatic hypotension 0.077 1 1.95e-3 2.83e-3 ✓ sig.
Familial mediterranean fever Hyperpituitarism 0.059 1 1.95e-3 2.83e-3 ✓ sig.
Antisocial personality disorder Congenital dyserythropoietic anemia 0.071 1 2.60e-3 3.51e-3 ✓ sig.
Hyperpituitarism Orthostatic hypotension 0.056 1 2.92e-3 3.87e-3 ✓ sig.
Conduct disorder Separation anxiety disorder 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Conduct disorder severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome 0.019 1 3.38e-3 4.37e-3 ✓ sig.