Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 409

6 diseases · 13 shared-gene connections
6 Diseases
21 Unique genes
0.243 Avg. similarity score
Adrenal adenoma Most-connected disease (5 links)
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Disease Searched: Adrenal adenoma Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Adrenal adenoma 5 5 1
Familial hyperaldosteronism type III 5 5 1
Hyperaldosteronism, familial, 3 5 5 1
Adrenal cortex neoplasm 4 4 10
Aldosterone-producing adenoma 4 4 14
Andersen-tawil syndrome 3 3 2

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
KCNJ5 6 / 6 Adrenal adenoma, Adrenal cortex neoplasm, Aldosterone-producing adenoma, Andersen-tawil syndrome and 2 more
CTNNB1 2 / 6 Adrenal cortex neoplasm, Aldosterone-producing adenoma
GNAS 2 / 6 Adrenal cortex neoplasm, Aldosterone-producing adenoma
TP53 2 / 6 Adrenal cortex neoplasm, Aldosterone-producing adenoma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Aldosterone synthesis and secretion
CACNA1D, KCNJ5, ATP2B3, ATP1A1, PRKACA, GNAS, GNA11
 KEGG 7 / 98 40.9× 2.05e-10 2.22e-8 ✓ sig.
Oxytocin signaling pathway
CACNA1D, KCNJ2, KCNJ5, PRKACA, NRAS, GNAS
 KEGG 6 / 154 22.3× 1.87e-7 9.64e-6 ✓ sig.
Cushing syndrome
CACNA1D, CTNNB1, PRKACA, GNAS, GNA11, ARNT
 KEGG 6 / 155 22.1× 1.94e-7 9.97e-6 ✓ sig.
Insulin secretion
CACNA1D, ATP1A1, PRKACA, GNAS, GNA11
 KEGG 5 / 86 33.3× 3.11e-7 1.51e-5 ✓ sig.
GnRH signaling pathway
CACNA1D, PRKACA, NRAS, GNAS, GNA11
 KEGG 5 / 93 30.7× 4.61e-7 2.13e-5 ✓ sig.
Cholinergic synapse
CACNA1D, KCNJ2, PRKACA, NRAS, GNA11
 KEGG 5 / 115 24.9× 1.33e-6 5.33e-5 ✓ sig.
Serotonergic synapse
CACNA1D, KCNJ5, PRKACA, NRAS, GNAS
 KEGG 5 / 115 24.9× 1.33e-6 5.33e-5 ✓ sig.
Thyroid hormone signaling pathway
ATP1A1, CTNNB1, TP53, PRKACA, NRAS
 KEGG 5 / 122 23.4× 1.78e-6 6.85e-5 ✓ sig.
Growth hormone synthesis, secretion and action
CACNA1D, PRKACA, NRAS, GNAS, GNA11
 KEGG 5 / 122 23.4× 1.78e-6 6.85e-5 ✓ sig.
Human cytomegalovirus infection
CTNNB1, TP53, PRKACA, NRAS, GNAS, GNA11
 KEGG 6 / 226 15.2× 1.78e-6 6.85e-5 ✓ sig.
Endocrine and other factor-regulated calcium reabsorption
ATP2B3, ATP1A1, PRKACA, GNAS
 KEGG 4 / 53 43.2× 1.91e-6 7.29e-5 ✓ sig.
Cortisol synthesis and secretion
CACNA1D, PRKACA, GNAS, GNA11
 KEGG 4 / 65 35.2× 4.36e-6 1.47e-4 ✓ sig.
GnRH secretion
CACNA1D, KCNJ5, NRAS, GNA11
 KEGG 4 / 65 35.2× 4.36e-6 1.47e-4 ✓ sig.
Renin secretion
CACNA1D, KCNJ2, PRKACA, GNAS
 KEGG 4 / 69 33.2× 5.55e-6 1.79e-4 ✓ sig.
Adrenergic signaling in cardiomyocytes
CACNA1D, ATP2B3, ATP1A1, PRKACA, GNAS
 KEGG 5 / 154 18.6× 5.60e-6 1.80e-4 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
intracellular potassium ion homeostasis
KCNJ2, ATP1A1, PRKACA
 GO:0030007 3 / 18 148× 9.87e-7 8.51e-5 ✓ sig.
cardiac muscle cell action potential involved in contraction
CACNA1D, KCNJ2, ATP1A1
 GO:0086002 3 / 24 111× 2.44e-6 1.78e-4 ✓ sig.
hair follicle placode formation
CTNNB1, GNAS
 GO:0060789 2 / 5 356× 1.20e-5 6.26e-4 ✓ sig.
regulation of heart rate by cardiac conduction
CACNA1D, KCNJ2, KCNJ5
 GO:0086091 3 / 43 62.1× 1.47e-5 7.31e-4 ✓ sig.
potassium ion import across plasma membrane
KCNJ2, KCNJ5, ATP1A1
 GO:1990573 3 / 46 58.0× 1.80e-5 8.55e-4 ✓ sig.
neuroblast proliferation
CTNNB1, TP53, NBN
 GO:0007405 3 / 48 55.6× 2.05e-5 9.42e-4 ✓ sig.
vascular endothelial cell response to laminar fluid shear stress
PRKACA, GNAS
 GO:0097700 2 / 9 198× 4.31e-5 1.65e-3 ✓ sig.
membrane repolarization during cardiac muscle cell action potential
KCNJ2, ATP1A1
 GO:0086013 2 / 10 178× 5.38e-5 1.95e-3 ✓ sig.
positive regulation of endothelial cell proliferation
RICTOR, NRAS, ARNT
 GO:0001938 3 / 69 38.7× 6.11e-5 2.15e-3 ✓ sig.
cellular response to glucagon stimulus
PRKACA, GNAS
 GO:0071377 2 / 11 162× 6.58e-5 2.26e-3 ✓ sig.
membrane depolarization during cardiac muscle cell action potential
CACNA1D, KCNJ2
 GO:0086012 2 / 12 148× 7.88e-5 2.60e-3 ✓ sig.
cell communication by electrical coupling involved in cardiac conduction
ATP1A1, PRKACA
 GO:0086064 2 / 12 148× 7.88e-5 2.60e-3 ✓ sig.
relaxation of cardiac muscle
KCNJ2, ATP1A1
 GO:0055119 2 / 13 137× 9.31e-5 2.93e-3 ✓ sig.
type II interferon-mediated signaling pathway
TP53, CIITA
 GO:0060333 2 / 15 119× 1.25e-4 3.63e-3 ✓ sig.
response to xenobiotic stimulus
ATP1A1, CTNNB1, TP53, DNMT3A
 GO:0009410 4 / 248 14.4× 1.52e-4 4.18e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Adrenal cortex neoplasm Aldosterone-producing adenoma 0.150 3 3.87e-8 2.87e-7 ✓ sig.
Adrenal adenoma Familial hyperaldosteronism type III 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Adrenal adenoma Hyperaldosteronism, familial, 3 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Familial hyperaldosteronism type III Hyperaldosteronism, familial, 3 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Adrenal adenoma Andersen-tawil syndrome 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Andersen-tawil syndrome Familial hyperaldosteronism type III 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Andersen-tawil syndrome Hyperaldosteronism, familial, 3 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Adrenal adenoma Adrenal cortex neoplasm 0.100 1 5.81e-4 1.00e-3 ✓ sig.
Adrenal cortex neoplasm Familial hyperaldosteronism type III 0.100 1 5.81e-4 1.00e-3 ✓ sig.
Adrenal cortex neoplasm Hyperaldosteronism, familial, 3 0.100 1 5.81e-4 1.00e-3 ✓ sig.
Adrenal adenoma Aldosterone-producing adenoma 0.071 1 8.39e-4 1.34e-3 ✓ sig.
Aldosterone-producing adenoma Familial hyperaldosteronism type III 0.071 1 8.39e-4 1.34e-3 ✓ sig.
Aldosterone-producing adenoma Hyperaldosteronism, familial, 3 0.071 1 8.39e-4 1.34e-3 ✓ sig.