Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5566
Gene name	Protein kinase cAMP-activated catalytic subunit alpha
Gene symbol	PRKACA
Synonyms (NCBI Gene)	CAFD1PKACAPPNAD4
Chromosome	19
Chromosome location	19p13.12
Summary	This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dime

SNP ID	Visualize variation	Clinical significance	Consequence
rs386352352	A>C	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs724160013	->CAC	Pathogenic	Coding sequence variant, inframe insertion

391 Show/Hide all (391)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030635	hsa-miR-22-3p	Sequencing	20371350
MIRT044041	hsa-miR-365a-3p	CLASH	23622248
MIRT043455	hsa-miR-331-3p	CLASH	23622248
MIRT043455	hsa-miR-331-3p	CLASH	23622248
MIRT042660	hsa-miR-196b-5p	CLASH	23622248
MIRT037509	hsa-miR-744-5p	CLASH	23622248
MIRT732472	hsa-miR-1275	qRT-PCR	33910530
MIRT732472	hsa-miR-1275	qRT-PCR	33910530
MIRT1262219	hsa-miR-1225-3p	CLIP-seq
MIRT1262220	hsa-miR-1233	CLIP-seq
MIRT1262221	hsa-miR-1285	CLIP-seq
MIRT1262222	hsa-miR-1305	CLIP-seq
MIRT1262223	hsa-miR-15a	CLIP-seq
MIRT1262224	hsa-miR-15b	CLIP-seq
MIRT1262225	hsa-miR-16	CLIP-seq
MIRT1262226	hsa-miR-1915	CLIP-seq
MIRT1262227	hsa-miR-195	CLIP-seq
MIRT1262228	hsa-miR-2355-5p	CLIP-seq
MIRT1262229	hsa-miR-3074-5p	CLIP-seq
MIRT1262230	hsa-miR-3124-3p	CLIP-seq
MIRT1262231	hsa-miR-3126-3p	CLIP-seq
MIRT1262232	hsa-miR-3175	CLIP-seq
MIRT1262233	hsa-miR-3184	CLIP-seq
MIRT1262234	hsa-miR-3187-5p	CLIP-seq
MIRT1262235	hsa-miR-342-5p	CLIP-seq
MIRT1262236	hsa-miR-3671	CLIP-seq
MIRT1262237	hsa-miR-370	CLIP-seq
MIRT1262238	hsa-miR-378g	CLIP-seq
MIRT1262239	hsa-miR-423-5p	CLIP-seq
MIRT1262240	hsa-miR-424	CLIP-seq
MIRT1262241	hsa-miR-4254	CLIP-seq
MIRT1262242	hsa-miR-4307	CLIP-seq
MIRT1262243	hsa-miR-4308	CLIP-seq
MIRT1262244	hsa-miR-4424	CLIP-seq
MIRT1262245	hsa-miR-4447	CLIP-seq
MIRT1262246	hsa-miR-4472	CLIP-seq
MIRT1262247	hsa-miR-4486	CLIP-seq
MIRT1262248	hsa-miR-4514	CLIP-seq
MIRT1262249	hsa-miR-4524	CLIP-seq
MIRT1262250	hsa-miR-4530	CLIP-seq
MIRT1262251	hsa-miR-4532	CLIP-seq
MIRT1262252	hsa-miR-4651	CLIP-seq
MIRT1262253	hsa-miR-4653-3p	CLIP-seq
MIRT1262254	hsa-miR-4660	CLIP-seq
MIRT1262255	hsa-miR-4664-5p	CLIP-seq
MIRT1262256	hsa-miR-4692	CLIP-seq
MIRT1262257	hsa-miR-4706	CLIP-seq
MIRT1262258	hsa-miR-4719	CLIP-seq
MIRT1262259	hsa-miR-4728-5p	CLIP-seq
MIRT1262260	hsa-miR-4749-3p	CLIP-seq
MIRT1262261	hsa-miR-4749-5p	CLIP-seq
MIRT1262262	hsa-miR-4781-5p	CLIP-seq
MIRT1262263	hsa-miR-4796-3p	CLIP-seq
MIRT1262264	hsa-miR-497	CLIP-seq
MIRT1262265	hsa-miR-503	CLIP-seq
MIRT1262266	hsa-miR-516a-3p	CLIP-seq
MIRT1262267	hsa-miR-539	CLIP-seq
MIRT1262268	hsa-miR-607	CLIP-seq
MIRT1262269	hsa-miR-608	CLIP-seq
MIRT1262270	hsa-miR-612	CLIP-seq
MIRT1262271	hsa-miR-646	CLIP-seq
MIRT1262272	hsa-miR-1207-5p	CLIP-seq
MIRT1262273	hsa-miR-1231	CLIP-seq
MIRT1262274	hsa-miR-1271	CLIP-seq
MIRT1262222	hsa-miR-1305	CLIP-seq
MIRT1262275	hsa-miR-1321	CLIP-seq
MIRT1262276	hsa-miR-149	CLIP-seq
MIRT1262277	hsa-miR-1587	CLIP-seq
MIRT1262278	hsa-miR-182	CLIP-seq
MIRT1262226	hsa-miR-1915	CLIP-seq
MIRT1262279	hsa-miR-2110	CLIP-seq
MIRT1262280	hsa-miR-216b	CLIP-seq
MIRT1262281	hsa-miR-219-1-3p	CLIP-seq
MIRT1262282	hsa-miR-298	CLIP-seq
MIRT1262283	hsa-miR-3064-5p	CLIP-seq
MIRT1262284	hsa-miR-3119	CLIP-seq
MIRT1262285	hsa-miR-3125	CLIP-seq
MIRT1262286	hsa-miR-3151	CLIP-seq
MIRT1262287	hsa-miR-3159	CLIP-seq
MIRT1262288	hsa-miR-3165	CLIP-seq
MIRT1262289	hsa-miR-3173-3p	CLIP-seq
MIRT1262233	hsa-miR-3184	CLIP-seq
MIRT1262290	hsa-miR-330-3p	CLIP-seq
MIRT1262291	hsa-miR-3612	CLIP-seq
MIRT1262292	hsa-miR-3667-3p	CLIP-seq
MIRT1262236	hsa-miR-3671	CLIP-seq
MIRT1262293	hsa-miR-3916	CLIP-seq
MIRT1262239	hsa-miR-423-5p	CLIP-seq
MIRT1262294	hsa-miR-4270	CLIP-seq
MIRT1262295	hsa-miR-4271	CLIP-seq
MIRT1262296	hsa-miR-4288	CLIP-seq
MIRT1262242	hsa-miR-4307	CLIP-seq
MIRT1262297	hsa-miR-4417	CLIP-seq
MIRT1262298	hsa-miR-4419a	CLIP-seq
MIRT1262299	hsa-miR-4441	CLIP-seq
MIRT1262245	hsa-miR-4447	CLIP-seq
MIRT1262300	hsa-miR-4456	CLIP-seq
MIRT1262246	hsa-miR-4472	CLIP-seq
MIRT1262301	hsa-miR-4476	CLIP-seq
MIRT1262302	hsa-miR-4492	CLIP-seq
MIRT1262303	hsa-miR-4498	CLIP-seq
MIRT1262304	hsa-miR-4505	CLIP-seq
MIRT1262305	hsa-miR-4510	CLIP-seq
MIRT1262248	hsa-miR-4514	CLIP-seq
MIRT1262306	hsa-miR-4533	CLIP-seq
MIRT1262307	hsa-miR-4645-5p	CLIP-seq
MIRT1262252	hsa-miR-4651	CLIP-seq
MIRT1262308	hsa-miR-4656	CLIP-seq
MIRT1262309	hsa-miR-4673	CLIP-seq
MIRT1262310	hsa-miR-4675	CLIP-seq
MIRT1262311	hsa-miR-4688	CLIP-seq
MIRT1262256	hsa-miR-4692	CLIP-seq
MIRT1262258	hsa-miR-4719	CLIP-seq
MIRT1262312	hsa-miR-4725-3p	CLIP-seq
MIRT1262313	hsa-miR-4726-3p	CLIP-seq
MIRT1262259	hsa-miR-4728-5p	CLIP-seq
MIRT1262314	hsa-miR-4731-5p	CLIP-seq
MIRT1262315	hsa-miR-4736	CLIP-seq
MIRT1262316	hsa-miR-4739	CLIP-seq
MIRT1262317	hsa-miR-4741	CLIP-seq
MIRT1262318	hsa-miR-4756-5p	CLIP-seq
MIRT1262319	hsa-miR-4763-3p	CLIP-seq
MIRT1262320	hsa-miR-4779	CLIP-seq
MIRT1262321	hsa-miR-4794	CLIP-seq
MIRT1262322	hsa-miR-4795-5p	CLIP-seq
MIRT1262263	hsa-miR-4796-3p	CLIP-seq
MIRT1262323	hsa-miR-486-3p	CLIP-seq
MIRT1262324	hsa-miR-491-5p	CLIP-seq
MIRT1262267	hsa-miR-539	CLIP-seq
MIRT1262325	hsa-miR-548c-3p	CLIP-seq
MIRT1262326	hsa-miR-580	CLIP-seq
MIRT1262268	hsa-miR-607	CLIP-seq
MIRT1262269	hsa-miR-608	CLIP-seq
MIRT1262327	hsa-miR-632	CLIP-seq
MIRT1262328	hsa-miR-637	CLIP-seq
MIRT1262329	hsa-miR-650	CLIP-seq
MIRT1262330	hsa-miR-668	CLIP-seq
MIRT1262331	hsa-miR-762	CLIP-seq
MIRT1262332	hsa-miR-877	CLIP-seq
MIRT1262333	hsa-miR-9	CLIP-seq
MIRT1262334	hsa-miR-940	CLIP-seq
MIRT1262335	hsa-miR-96	CLIP-seq
MIRT1556845	hsa-miR-4723-5p	CLIP-seq
MIRT2077308	hsa-miR-1208	CLIP-seq
MIRT2077309	hsa-miR-1224-5p	CLIP-seq
MIRT2077310	hsa-miR-1246	CLIP-seq
MIRT2077311	hsa-miR-1290	CLIP-seq
MIRT2077312	hsa-miR-1304	CLIP-seq
MIRT2077313	hsa-miR-146a	CLIP-seq
MIRT2077314	hsa-miR-146b-5p	CLIP-seq
MIRT1262276	hsa-miR-149	CLIP-seq
MIRT1262277	hsa-miR-1587	CLIP-seq
MIRT1262226	hsa-miR-1915	CLIP-seq
MIRT1262280	hsa-miR-216b	CLIP-seq
MIRT2077315	hsa-miR-296-5p	CLIP-seq
MIRT1262283	hsa-miR-3064-5p	CLIP-seq
MIRT1262285	hsa-miR-3125	CLIP-seq
MIRT2077316	hsa-miR-3135b	CLIP-seq
MIRT2077317	hsa-miR-3148	CLIP-seq
MIRT2077318	hsa-miR-3150a-3p	CLIP-seq
MIRT2077319	hsa-miR-3157-3p	CLIP-seq
MIRT1262287	hsa-miR-3159	CLIP-seq
MIRT2077320	hsa-miR-3167	CLIP-seq
MIRT1262232	hsa-miR-3175	CLIP-seq
MIRT2077321	hsa-miR-3192	CLIP-seq
MIRT2077322	hsa-miR-335	CLIP-seq
MIRT2077323	hsa-miR-3662	CLIP-seq
MIRT1262292	hsa-miR-3667-3p	CLIP-seq
MIRT2077324	hsa-miR-3689a-3p	CLIP-seq
MIRT2077325	hsa-miR-3689c	CLIP-seq
MIRT2077326	hsa-miR-3915	CLIP-seq
MIRT1262293	hsa-miR-3916	CLIP-seq
MIRT2077327	hsa-miR-3928	CLIP-seq
MIRT2077328	hsa-miR-4251	CLIP-seq
MIRT2077329	hsa-miR-4259	CLIP-seq
MIRT2077330	hsa-miR-4260	CLIP-seq
MIRT2077331	hsa-miR-4283	CLIP-seq
MIRT1262242	hsa-miR-4307	CLIP-seq
MIRT2077332	hsa-miR-4324	CLIP-seq
MIRT1262244	hsa-miR-4424	CLIP-seq
MIRT1262245	hsa-miR-4447	CLIP-seq
MIRT1262300	hsa-miR-4456	CLIP-seq
MIRT1262246	hsa-miR-4472	CLIP-seq
MIRT1262301	hsa-miR-4476	CLIP-seq
MIRT2077333	hsa-miR-4489	CLIP-seq
MIRT1262302	hsa-miR-4492	CLIP-seq
MIRT1262303	hsa-miR-4498	CLIP-seq
MIRT1262248	hsa-miR-4514	CLIP-seq
MIRT2077334	hsa-miR-451b	CLIP-seq
MIRT1262251	hsa-miR-4532	CLIP-seq
MIRT1262306	hsa-miR-4533	CLIP-seq
MIRT1262307	hsa-miR-4645-5p	CLIP-seq
MIRT2077335	hsa-miR-4650-5p	CLIP-seq
MIRT1262252	hsa-miR-4651	CLIP-seq
MIRT1262253	hsa-miR-4653-3p	CLIP-seq
MIRT2077336	hsa-miR-4665-5p	CLIP-seq
MIRT1262309	hsa-miR-4673	CLIP-seq
MIRT2077337	hsa-miR-4674	CLIP-seq
MIRT2077338	hsa-miR-4689	CLIP-seq
MIRT1262256	hsa-miR-4692	CLIP-seq
MIRT2077339	hsa-miR-4694-3p	CLIP-seq
MIRT1262313	hsa-miR-4726-3p	CLIP-seq
MIRT1262259	hsa-miR-4728-5p	CLIP-seq
MIRT1262314	hsa-miR-4731-5p	CLIP-seq
MIRT1262260	hsa-miR-4749-3p	CLIP-seq
MIRT2077340	hsa-miR-4753-3p	CLIP-seq
MIRT2077341	hsa-miR-4758-3p	CLIP-seq
MIRT1262321	hsa-miR-4794	CLIP-seq
MIRT1262266	hsa-miR-516a-3p	CLIP-seq
MIRT2077342	hsa-miR-548u	CLIP-seq
MIRT2077343	hsa-miR-571	CLIP-seq
MIRT2077344	hsa-miR-579	CLIP-seq
MIRT2077345	hsa-miR-589	CLIP-seq
MIRT1262269	hsa-miR-608	CLIP-seq
MIRT2077346	hsa-miR-622	CLIP-seq
MIRT2077347	hsa-miR-625	CLIP-seq
MIRT2077348	hsa-miR-635	CLIP-seq
MIRT1262328	hsa-miR-637	CLIP-seq
MIRT1262331	hsa-miR-762	CLIP-seq
MIRT2077349	hsa-miR-874	CLIP-seq
MIRT2077350	hsa-miR-876-5p	CLIP-seq
MIRT1262332	hsa-miR-877	CLIP-seq
MIRT2077351	hsa-miR-938	CLIP-seq
MIRT1262334	hsa-miR-940	CLIP-seq
MIRT2077352	hsa-miR-942	CLIP-seq
MIRT2303762	hsa-miR-1207-3p	CLIP-seq
MIRT2077308	hsa-miR-1208	CLIP-seq
MIRT1262219	hsa-miR-1225-3p	CLIP-seq
MIRT1262220	hsa-miR-1233	CLIP-seq
MIRT2303763	hsa-miR-1262	CLIP-seq
MIRT2303764	hsa-miR-138	CLIP-seq
MIRT1262277	hsa-miR-1587	CLIP-seq
MIRT2303765	hsa-miR-2392	CLIP-seq
MIRT1262230	hsa-miR-3124-3p	CLIP-seq
MIRT1262285	hsa-miR-3125	CLIP-seq
MIRT2077316	hsa-miR-3135b	CLIP-seq
MIRT1262287	hsa-miR-3159	CLIP-seq
MIRT1262289	hsa-miR-3173-3p	CLIP-seq
MIRT1262233	hsa-miR-3184	CLIP-seq
MIRT2077321	hsa-miR-3192	CLIP-seq
MIRT2303766	hsa-miR-320e	CLIP-seq
MIRT2077322	hsa-miR-335	CLIP-seq
MIRT2303767	hsa-miR-3652	CLIP-seq
MIRT2077324	hsa-miR-3689a-3p	CLIP-seq
MIRT2077325	hsa-miR-3689c	CLIP-seq
MIRT1262293	hsa-miR-3916	CLIP-seq
MIRT1262239	hsa-miR-423-5p	CLIP-seq
MIRT2303768	hsa-miR-4286	CLIP-seq
MIRT2303769	hsa-miR-4290	CLIP-seq
MIRT1262298	hsa-miR-4419a	CLIP-seq
MIRT2303770	hsa-miR-4430	CLIP-seq
MIRT1262245	hsa-miR-4447	CLIP-seq
MIRT1262300	hsa-miR-4456	CLIP-seq
MIRT2303771	hsa-miR-4459	CLIP-seq
MIRT1262246	hsa-miR-4472	CLIP-seq
MIRT1262301	hsa-miR-4476	CLIP-seq
MIRT1262302	hsa-miR-4492	CLIP-seq
MIRT1262303	hsa-miR-4498	CLIP-seq
MIRT1262305	hsa-miR-4510	CLIP-seq
MIRT1262248	hsa-miR-4514	CLIP-seq
MIRT2303772	hsa-miR-4525	CLIP-seq
MIRT1262252	hsa-miR-4651	CLIP-seq
MIRT1262253	hsa-miR-4653-3p	CLIP-seq
MIRT2077336	hsa-miR-4665-5p	CLIP-seq
MIRT1262256	hsa-miR-4692	CLIP-seq
MIRT2303773	hsa-miR-4701-3p	CLIP-seq
MIRT2303774	hsa-miR-4716-3p	CLIP-seq
MIRT2303775	hsa-miR-4722-5p	CLIP-seq
MIRT1556845	hsa-miR-4723-5p	CLIP-seq
MIRT1262259	hsa-miR-4728-5p	CLIP-seq
MIRT1262314	hsa-miR-4731-5p	CLIP-seq
MIRT1262260	hsa-miR-4749-3p	CLIP-seq
MIRT1262320	hsa-miR-4779	CLIP-seq
MIRT1262263	hsa-miR-4796-3p	CLIP-seq
MIRT1262323	hsa-miR-486-3p	CLIP-seq
MIRT2303776	hsa-miR-512-5p	CLIP-seq
MIRT2303777	hsa-miR-541	CLIP-seq
MIRT2303778	hsa-miR-587	CLIP-seq
MIRT1262269	hsa-miR-608	CLIP-seq
MIRT2077347	hsa-miR-625	CLIP-seq
MIRT1262271	hsa-miR-646	CLIP-seq
MIRT2303779	hsa-miR-654-5p	CLIP-seq
MIRT2303780	hsa-miR-658	CLIP-seq
MIRT1262331	hsa-miR-762	CLIP-seq
MIRT2303781	hsa-miR-939	CLIP-seq
MIRT1262334	hsa-miR-940	CLIP-seq
MIRT2303762	hsa-miR-1207-3p	CLIP-seq
MIRT1262233	hsa-miR-3184	CLIP-seq
MIRT1262239	hsa-miR-423-5p	CLIP-seq
MIRT1262242	hsa-miR-4307	CLIP-seq
MIRT1262298	hsa-miR-4419a	CLIP-seq
MIRT1262305	hsa-miR-4510	CLIP-seq
MIRT1262260	hsa-miR-4749-3p	CLIP-seq
MIRT1262268	hsa-miR-607	CLIP-seq
MIRT1262271	hsa-miR-646	CLIP-seq
MIRT1262272	hsa-miR-1207-5p	CLIP-seq
MIRT1262273	hsa-miR-1231	CLIP-seq
MIRT2600659	hsa-miR-1267	CLIP-seq
MIRT1262274	hsa-miR-1271	CLIP-seq
MIRT1262276	hsa-miR-149	CLIP-seq
MIRT1262278	hsa-miR-182	CLIP-seq
MIRT1262226	hsa-miR-1915	CLIP-seq
MIRT1262279	hsa-miR-2110	CLIP-seq
MIRT1262280	hsa-miR-216b	CLIP-seq
MIRT1262283	hsa-miR-3064-5p	CLIP-seq
MIRT1262284	hsa-miR-3119	CLIP-seq
MIRT2600660	hsa-miR-3147	CLIP-seq
MIRT2077317	hsa-miR-3148	CLIP-seq
MIRT2077318	hsa-miR-3150a-3p	CLIP-seq
MIRT1262287	hsa-miR-3159	CLIP-seq
MIRT1262233	hsa-miR-3184	CLIP-seq
MIRT2600661	hsa-miR-3188	CLIP-seq
MIRT1262290	hsa-miR-330-3p	CLIP-seq
MIRT1262292	hsa-miR-3667-3p	CLIP-seq
MIRT1262239	hsa-miR-423-5p	CLIP-seq
MIRT1262294	hsa-miR-4270	CLIP-seq
MIRT1262295	hsa-miR-4271	CLIP-seq
MIRT1262296	hsa-miR-4288	CLIP-seq
MIRT2600662	hsa-miR-4311	CLIP-seq
MIRT2600663	hsa-miR-4425	CLIP-seq
MIRT1262299	hsa-miR-4441	CLIP-seq
MIRT1262301	hsa-miR-4476	CLIP-seq
MIRT2600664	hsa-miR-4509	CLIP-seq
MIRT1262248	hsa-miR-4514	CLIP-seq
MIRT1262307	hsa-miR-4645-5p	CLIP-seq
MIRT2600665	hsa-miR-4668-5p	CLIP-seq
MIRT1262309	hsa-miR-4673	CLIP-seq
MIRT1262311	hsa-miR-4688	CLIP-seq
MIRT1262256	hsa-miR-4692	CLIP-seq
MIRT1262312	hsa-miR-4725-3p	CLIP-seq
MIRT1262313	hsa-miR-4726-3p	CLIP-seq
MIRT1262315	hsa-miR-4736	CLIP-seq
MIRT1262319	hsa-miR-4763-3p	CLIP-seq
MIRT1262321	hsa-miR-4794	CLIP-seq
MIRT1262323	hsa-miR-486-3p	CLIP-seq
MIRT1262266	hsa-miR-516a-3p	CLIP-seq
MIRT1262325	hsa-miR-548c-3p	CLIP-seq
MIRT1262268	hsa-miR-607	CLIP-seq
MIRT1262327	hsa-miR-632	CLIP-seq
MIRT2303780	hsa-miR-658	CLIP-seq
MIRT1262330	hsa-miR-668	CLIP-seq
MIRT1262333	hsa-miR-9	CLIP-seq
MIRT1262334	hsa-miR-940	CLIP-seq
MIRT1262335	hsa-miR-96	CLIP-seq
MIRT1262272	hsa-miR-1207-5p	CLIP-seq
MIRT1262273	hsa-miR-1231	CLIP-seq
MIRT2600659	hsa-miR-1267	CLIP-seq
MIRT1262274	hsa-miR-1271	CLIP-seq
MIRT1262276	hsa-miR-149	CLIP-seq
MIRT1262278	hsa-miR-182	CLIP-seq
MIRT1262226	hsa-miR-1915	CLIP-seq
MIRT1262279	hsa-miR-2110	CLIP-seq
MIRT1262280	hsa-miR-216b	CLIP-seq
MIRT1262283	hsa-miR-3064-5p	CLIP-seq
MIRT1262284	hsa-miR-3119	CLIP-seq
MIRT2600660	hsa-miR-3147	CLIP-seq
MIRT2077317	hsa-miR-3148	CLIP-seq
MIRT2077318	hsa-miR-3150a-3p	CLIP-seq
MIRT1262287	hsa-miR-3159	CLIP-seq
MIRT1262233	hsa-miR-3184	CLIP-seq
MIRT2600661	hsa-miR-3188	CLIP-seq
MIRT1262290	hsa-miR-330-3p	CLIP-seq
MIRT1262292	hsa-miR-3667-3p	CLIP-seq
MIRT1262239	hsa-miR-423-5p	CLIP-seq
MIRT1262294	hsa-miR-4270	CLIP-seq
MIRT1262295	hsa-miR-4271	CLIP-seq
MIRT1262296	hsa-miR-4288	CLIP-seq
MIRT2600662	hsa-miR-4311	CLIP-seq
MIRT2600663	hsa-miR-4425	CLIP-seq
MIRT1262299	hsa-miR-4441	CLIP-seq
MIRT1262248	hsa-miR-4514	CLIP-seq
MIRT1262307	hsa-miR-4645-5p	CLIP-seq
MIRT2600665	hsa-miR-4668-5p	CLIP-seq
MIRT1262309	hsa-miR-4673	CLIP-seq
MIRT1262311	hsa-miR-4688	CLIP-seq
MIRT1262256	hsa-miR-4692	CLIP-seq
MIRT1262312	hsa-miR-4725-3p	CLIP-seq
MIRT1262313	hsa-miR-4726-3p	CLIP-seq
MIRT1262315	hsa-miR-4736	CLIP-seq
MIRT1262319	hsa-miR-4763-3p	CLIP-seq
MIRT1262321	hsa-miR-4794	CLIP-seq
MIRT1262323	hsa-miR-486-3p	CLIP-seq
MIRT1262266	hsa-miR-516a-3p	CLIP-seq
MIRT1262325	hsa-miR-548c-3p	CLIP-seq
MIRT1262268	hsa-miR-607	CLIP-seq
MIRT1262327	hsa-miR-632	CLIP-seq
MIRT2303780	hsa-miR-658	CLIP-seq
MIRT1262330	hsa-miR-668	CLIP-seq
MIRT1262333	hsa-miR-9	CLIP-seq
MIRT1262334	hsa-miR-940	CLIP-seq
MIRT1262335	hsa-miR-96	CLIP-seq

127 Show/Hide all (127)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0001669	Component	Acrosomal vesicle	ISS
GO:0001707	Process	Mesoderm formation	IEA
GO:0001843	Process	Neural tube closure	IEA
GO:0002027	Process	Regulation of heart rate	TAS	23507255
GO:0003091	Process	Renal water homeostasis	TAS
GO:0004672	Function	Protein kinase activity	IDA	12475942
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	21085490
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IMP	26537248
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004691	Function	CAMP-dependent protein kinase activity	IBA
GO:0004691	Function	CAMP-dependent protein kinase activity	IDA	11029056, 21812984, 31112131, 38503280
GO:0004691	Function	CAMP-dependent protein kinase activity	IEA
GO:0004691	Function	CAMP-dependent protein kinase activity	ISS
GO:0004691	Function	CAMP-dependent protein kinase activity	NAS	2843813
GO:0004691	Function	CAMP-dependent protein kinase activity	TAS
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IDA	22797923
GO:0005515	Function	Protein binding	IPI	11035810, 12475942, 15630084, 15655353, 16376338, 16387847, 17148597, 17911601, 18836454, 21085490, 21812984, 23455922, 23602568, 24351927, 24464040, 24605759, 24700472, 24855271, 24860872, 25477193, 26496610, 27107012, 29568061, 31980649, 32296183, 32707033, 32814053, 33058759, 339
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21085490
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IC	22797923
GO:0005737	Component	Cytoplasm	IDA	21085490
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	15569306
GO:0005886	Component	Plasma membrane	IEA
GO:0005929	Component	Cilium	IEA
GO:0005930	Component	Axoneme	IDA	12475942
GO:0005952	Component	CAMP-dependent protein kinase complex	IBA
GO:0005952	Component	CAMP-dependent protein kinase complex	IDA	12475942
GO:0005952	Component	CAMP-dependent protein kinase complex	IEA
GO:0005952	Component	CAMP-dependent protein kinase complex	NAS	2843813
GO:0006397	Process	MRNA processing	IDA	17594903
GO:0006468	Process	Protein phosphorylation	IDA	12475942
GO:0006468	Process	Protein phosphorylation	NAS	2843813
GO:0006611	Process	Protein export from nucleus	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	38503280
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	TAS	23507255
GO:0016020	Component	Membrane	IEA
GO:0016241	Process	Regulation of macroautophagy	TAS	26046386
GO:0016301	Function	Kinase activity	IEA
GO:0016607	Component	Nuclear speck	IDA	17594903
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	10805756, 11029056
GO:0018105	Process	Peptidyl-serine phosphorylation	IMP	26537248
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019901	Function	Protein kinase binding	IPI	11035810, 17911601
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030007	Process	Intracellular potassium ion homeostasis	IDA	10636900, 22797923
GO:0030007	Process	Intracellular potassium ion homeostasis	IDA	22797923
GO:0030145	Function	Manganese ion binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0031588	Component	Nucleotide-activated protein kinase complex	IDA	21812984
GO:0031594	Component	Neuromuscular junction	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	21423175
GO:0031669	Process	Cellular response to nutrient levels	IDA	12747827, 29750193
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032703	Process	Negative regulation of interleukin-2 production	ISS	29457279
GO:0034237	Function	Protein kinase A regulatory subunit binding	IBA
GO:0034237	Function	Protein kinase A regulatory subunit binding	IEA
GO:0034237	Function	Protein kinase A regulatory subunit binding	IPI	17911601, 21812984
GO:0034380	Process	High-density lipoprotein particle assembly	TAS
GO:0034605	Process	Cellular response to heat	IDA	21085490
GO:0034704	Component	Calcium channel complex	TAS	23507255
GO:0035694	Process	Mitochondrial protein catabolic process	TAS
GO:0036126	Component	Sperm flagellum	IEA
GO:0038110	Process	Interleukin-2-mediated signaling pathway	IDA	22844114
GO:0038202	Process	TORC1 signaling	IDA	12747827, 29750193
GO:0042995	Component	Cell projection	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IC	22797923
GO:0044853	Component	Plasma membrane raft	IDA	17911601
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IDA	38503280
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IDA	38503280
GO:0045667	Process	Regulation of osteoblast differentiation	IDA	19949837
GO:0045722	Process	Positive regulation of gluconeogenesis	IEA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	IEA
GO:0046827	Process	Positive regulation of protein export from nucleus	IEA
GO:0048240	Process	Sperm capacitation	IEA
GO:0048240	Process	Sperm capacitation	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21085490
GO:0050766	Process	Positive regulation of phagocytosis	IDA	27994074
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	TAS	23507255
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	ISS
GO:0055117	Process	Regulation of cardiac muscle contraction	TAS	23507255
GO:0061136	Process	Regulation of proteasomal protein catabolic process	IDA	17565987
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070417	Process	Cellular response to cold	IEA
GO:0070613	Process	Regulation of protein processing	IEA
GO:0071333	Process	Cellular response to glucose stimulus	IDA	19949837
GO:0071374	Process	Cellular response to parathyroid hormone stimulus	IEA
GO:0071377	Process	Cellular response to glucagon stimulus	IEA
GO:0071872	Process	Cellular response to epinephrine stimulus	TAS	23507255
GO:0086064	Process	Cell communication by electrical coupling involved in cardiac conduction	TAS	23507255
GO:0097225	Component	Sperm midpiece	IDA	10906071
GO:0097546	Component	Ciliary base	IEA
GO:0097546	Component	Ciliary base	TAS
GO:0097700	Process	Vascular endothelial cell response to laminar fluid shear stress	TAS
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099103	Function	Channel activator activity	TAS	23507255
GO:0099170	Process	Postsynaptic modulation of chemical synaptic transmission	IEA
GO:0106310	Function	Protein serine kinase activity	IDA	22797923
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0141156	Process	CAMP/PKA signal transduction	IDA	21812984
GO:1903779	Process	Regulation of cardiac conduction	TAS
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	31112131
GO:1904539	Process	Negative regulation of glycolytic process through fructose-6-phosphate	IEA
GO:1990044	Process	Protein localization to lipid droplet	IEA
GO:2000810	Process	Regulation of bicellular tight junction assembly	IDA	15905176

MIM	HGNC	e!Ensembl
601639	9380	ENSG00000072062

P17612

Protein name

cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)

Protein function

Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:2108549

PDB

2GU8 , 3AGL , 3AGM , 3AMA , 3AMB , 3L9L , 3L9M , 3L9N , 3MVJ , 3NX8 , 3OOG , 3OVV , 3OWP , 3OXT , 3P0M , 3POO , 3VQH , 4AE6 , 4AE9 , 4UJ1 , 4UJ2 , 4UJ9 , 4UJA , 4UJB , 4WB5 , 4WB6 , 4WB7 , 4WB8 , 5BX6 , 5BX7 , 5IZF , 5IZJ , 5J5X , 5N23 , 5UZK , 6BYR , 6BYS , 6C0U , 6FRX , 6NO7 , 6QJ7 , 6WJF , 6WJG , 7Y1G , 8FE2 , 8FE5 , 8FEC , 8X5L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	44 → 298	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is ubiquitous. Isoform 2 is sperm-specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. {ECO:0000269|PubMed:10906071, ECO:0000269|PubMed:21812984}.

Sequence

MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF

Sequence length

351

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocrine resistance	PKA activation
MAPK signaling pathway	PKA activation in glucagon signalling
Ras signaling pathway	DARPP-32 events
Calcium signaling pathway	Regulation of PLK1 Activity at G2/M Transition
cAMP signaling pathway	Loss of Nlp from mitotic centrosomes
Chemokine signaling pathway	Recruitment of mitotic centrosome proteins and complexes
Hormone signaling	Loss of proteins required for interphase microtubule organization from the centrosome
Oocyte meiosis	Recruitment of NuMA to mitotic centrosomes
Autophagy - animal	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Longevity regulating pathway	Rap1 signalling
Longevity regulating pathway - multiple species	Regulation of insulin secretion
Adrenergic signaling in cardiomyocytes	Vasopressin regulates renal water homeostasis via Aquaporins
Vascular smooth muscle contraction	VEGFA-VEGFR2 Pathway
Wnt signaling pathway	CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog signaling pathway	Interleukin-3, Interleukin-5 and GM-CSF signaling
Apelin signaling pathway	Ion homeostasis
Tight junction	GLI3 is processed to GLI3R by the proteasome
Gap junction	Hedgehog 'off' state
Platelet activation	Anchoring of the basal body to the plasma membrane
Circadian entrainment	CD209 (DC-SIGN) signaling
Thermogenesis	MAPK6/MAPK4 signaling
Long-term potentiation	RET signaling
Retrograde endocannabinoid signaling	AURKA Activation by TPX2
Glutamatergic synapse	HDL assembly
Cholinergic synapse	ADORA2B mediated anti-inflammatory cytokines production
Serotonergic synapse	FCGR3A-mediated IL10 synthesis
GABAergic synapse	Factors involved in megakaryocyte development and platelet production
Dopaminergic synapse
Olfactory transduction
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Aldosterone synthesis and secretion
Relaxin signaling pathway
Cortisol synthesis and secretion
Parathyroid hormone synthesis, secretion and action
Cushing syndrome
Growth hormone synthesis, secretion and action
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Parkinson disease
Prion disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Amoebiasis
Human cytomegalovirus infection
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Chemical carcinogenesis - receptor activation
Dilated cardiomyopathy

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
ACTH-independent adrenal Cushing syndrome, somatic	Likely pathogenic; Pathogenic	rs386352352	RCV002508139	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Adrenal cortex neoplasm	Likely pathogenic; Pathogenic	rs386352352	RCV006253780	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cardioacrofacial dysplasia 1	Likely pathogenic; Pathogenic	rs148280386	RCV001271119	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Pigmented nodular adrenocortical disease, primary, 4	Pathogenic; Likely pathogenic	rs724160013, rs386352352	RCV000149856 RCV000119834	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (11)
CHOLANGIOCARCINOMA	—	CTD	26258846	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGESTIVE HEART FAILURE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ELLIS VAN CREVELD SYNDROME	—	Orphanet	33058759	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ELLIS-VAN CREVELD SYNDROME	—	Disgenet, HPO Disgenet, HPO	33058759	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	29341352	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRKACA-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PRKACB	3	["Cardiofacial dysplasia","Cholangiocarcinoma","Ellis-van creveld syndrome"]	86	["Endocrine resistance","MAPK signaling pathway","Ras signaling pathway","Calcium signaling pathway","cAMP signaling pathway","Chemokine signaling pathway","Hormone signaling","Oocyte meiosis","Autophagy - animal","Longevity regulating pathway","Longevity regulating pathway - multiple species","Adrenergic signaling in cardiomyocytes"]	6	["ClinVar (Cardiofacial dysplasia)","Disgenet (Cardiofacial dysplasia)","HPO (Cardiofacial dysplasia)","CTD (Cholangiocarcinoma)","Orphanet (Ellis-van creveld syndrome)","Disgenet (Ellis-van creveld syndrome)"]
PRKACG	0	[]	86	["Endocrine resistance","MAPK signaling pathway","Ras signaling pathway","Calcium signaling pathway","cAMP signaling pathway","Chemokine signaling pathway","Hormone signaling","Oocyte meiosis","Autophagy - animal","Longevity regulating pathway","Longevity regulating pathway - multiple species","Adrenergic signaling in cardiomyocytes"]	0	[]
ADCY5	0	[]	56	["Endocrine resistance","cAMP signaling pathway","Chemokine signaling pathway","Hormone signaling","Oocyte meiosis","Longevity regulating pathway","Longevity regulating pathway - multiple species","Adrenergic signaling in cardiomyocytes","Vascular smooth muscle contraction","Apelin signaling pathway","Gap junction","Platelet activation"]	0	[]
ADCY6	0	[]	53	["Endocrine resistance","cAMP signaling pathway","Chemokine signaling pathway","Hormone signaling","Oocyte meiosis","Longevity regulating pathway","Longevity regulating pathway - multiple species","Adrenergic signaling in cardiomyocytes","Vascular smooth muscle contraction","Apelin signaling pathway","Gap junction","Platelet activation"]	0	[]
ADCY8	0	[]	52	["Endocrine resistance","Calcium signaling pathway","cAMP signaling pathway","Chemokine signaling pathway","Hormone signaling","Oocyte meiosis","Longevity regulating pathway","Longevity regulating pathway - multiple species","Adrenergic signaling in cardiomyocytes","Vascular smooth muscle contraction","Apelin signaling pathway","Gap junction"]	0	[]

PRKACA (protein kinase cAMP-activated catalytic subunit alpha)

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