Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 565
5
Diseases
46
Unique genes
0.169
Avg. similarity score
Erythematosquamous dermatosis
Most-connected disease (3 links)
Disease
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Erythematosquamous dermatosis
Sebaceous gland disease
Seborrheic dermatitis
Pityriasis rubra pilaris
Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Erythematosquamous dermatosis | 3 | 3 | 22 |
| Sebaceous gland disease | 3 | 3 | 14 |
| Seborrheic dermatitis | 3 | 3 | 37 |
| Pityriasis rubra pilaris | 2 | 2 | 1 |
| Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| CARD14 | 3 / 5 | Erythematosquamous dermatosis, Pityriasis rubra pilaris, Seborrheic dermatitis |
| HERC2 | 3 / 5 | Erythematosquamous dermatosis, Sebaceous gland disease, Seborrheic dermatitis |
| IRF4 | 3 / 5 | Erythematosquamous dermatosis, Sebaceous gland disease, Seborrheic dermatitis |
| MC1R | 3 / 5 | Erythematosquamous dermatosis, Sebaceous gland disease, Seborrheic dermatitis |
| RALY | 3 / 5 | Erythematosquamous dermatosis, Sebaceous gland disease, Seborrheic dermatitis |
| SLC45A2 | 3 / 5 | Erythematosquamous dermatosis, Sebaceous gland disease, Seborrheic dermatitis |
| TYR | 3 / 5 | Erythematosquamous dermatosis, Sebaceous gland disease, Seborrheic dermatitis |
| FAM8A1 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| FLYWCH2 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| FOXP1 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| IL23R | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| IL2RA | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| KLK6 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| KLK7 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| POLI | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| PRSS22 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| SPINK5 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| TAP2 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| TYK2 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| ZBTB7A | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| ZMIZ1 | 2 / 5 | Erythematosquamous dermatosis, Seborrheic dermatitis |
| ZNF668 | 2 / 5 | Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies, Sebaceous gland disease |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Interleukin-4 and Interleukin-13 signaling | Reactome | 5 / 108 | 12.1× | 5.48e-5 | 1.17e-3 ✓ sig. |
| Melanin biosynthesis | Reactome | 2 / 5 | 104× | 1.42e-4 | 2.51e-3 ✓ sig. |
| Interleukin-23 signaling | Reactome | 2 / 9 | 58.0× | 5.08e-4 | 6.75e-3 ✓ sig. |
| Th17 cell differentiation | KEGG | 4 / 109 | 9.6× | 7.81e-4 | 9.37e-3 ✓ sig. |
| Measles | KEGG | 4 / 139 | 7.5× | 1.92e-3 | 1.85e-2 ✓ sig. |
| Inflammatory bowel disease | KEGG | 3 / 66 | 11.9× | 2.03e-3 | 1.92e-2 ✓ sig. |
| Interferon alpha/beta signaling | Reactome | 3 / 67 | 11.7× | 2.12e-3 | 1.99e-2 ✓ sig. |
| JAK-STAT signaling pathway | KEGG | 4 / 168 | 6.2× | 3.82e-3 | 3.02e-2 ✓ sig. |
| Herpes simplex virus 1 infection | KEGG | 4 / 182 | 5.7× | 5.07e-3 | 3.68e-2 ✓ sig. |
| Th1 and Th2 cell differentiation | KEGG | 3 / 93 | 8.4× | 5.36e-3 | 3.82e-2 ✓ sig. |
| ER-Phagosome pathway | Reactome | 2 / 30 | 17.4× | 5.83e-3 | 4.04e-2 ✓ sig. |
| Epstein-Barr virus infection | KEGG | 4 / 204 | 5.1× | 7.56e-3 | 4.77e-2 ✓ sig. |
| Regulation of TP53 Expression | Reactome | 1 / 2 | 131× | 7.65e-3 | 4.81e-2 ✓ sig. |
| Transcriptional activation of cell cycle inhibitor p21 | Reactome | 1 / 4 | 65.3× | 1.52e-2 | 7.32e-2 |
| Toll Like Receptor TLR6:TLR2 Cascade | Reactome | 1 / 4 | 65.3× | 1.52e-2 | 7.32e-2 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| melanin biosynthetic process | GO:0042438 | 3 / 14 | 87.1× | 4.99e-6 | 3.17e-4 ✓ sig. |
| type II interferon-mediated signaling pathway | GO:0060333 | 3 / 15 | 81.2× | 6.22e-6 | 3.77e-4 ✓ sig. |
| melanin biosynthetic process from tyrosine | GO:0006583 | 2 / 4 | 203× | 3.55e-5 | 1.42e-3 ✓ sig. |
| interleukin-23-mediated signaling pathway | GO:0038155 | 2 / 6 | 135× | 8.84e-5 | 2.82e-3 ✓ sig. |
| positive regulation of interleukin-12 production | GO:0032735 | 3 / 43 | 28.3× | 1.61e-4 | 4.35e-3 ✓ sig. |
| positive regulation of natural killer cell proliferation | GO:0032819 | 2 / 12 | 67.7× | 3.85e-4 | 7.96e-3 ✓ sig. |
| apoptotic process | GO:0006915 | 8 / 747 | 4.4× | 4.26e-4 | 8.53e-3 ✓ sig. |
| positive regulation of T-helper 17 type immune response | GO:2000318 | 2 / 13 | 62.5× | 4.54e-4 | 8.91e-3 ✓ sig. |
| positive regulation of calcium ion-dependent exocytosis | GO:0045956 | 2 / 14 | 58.0× | 5.29e-4 | 9.88e-3 ✓ sig. |
| positive regulation of T cell proliferation | GO:0042102 | 3 / 67 | 18.2× | 5.99e-4 | 1.07e-2 ✓ sig. |
| negative regulation of androgen receptor signaling pathway | GO:0060766 | 2 / 17 | 47.8× | 7.87e-4 | 1.27e-2 ✓ sig. |
| inflammatory response | GO:0006954 | 6 / 467 | 5.2× | 9.47e-4 | 1.42e-2 ✓ sig. |
| positive regulation of NF-kappaB transcription factor activity | GO:0051092 | 3 / 80 | 15.2× | 1.00e-3 | 1.47e-2 ✓ sig. |
| macrophage activation | GO:0042116 | 2 / 23 | 35.3× | 1.45e-3 | 1.80e-2 ✓ sig. |
| protein autoprocessing | GO:0016540 | 2 / 25 | 32.5× | 1.72e-3 | 1.96e-2 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Erythematosquamous dermatosis | Seborrheic dermatitis | 0.538 | 21 | 1.50e-57 | 4.38e-56 ✓ sig. |
| Erythematosquamous dermatosis | Sebaceous gland disease | 0.200 | 6 | 6.64e-15 | 7.99e-14 ✓ sig. |
| Sebaceous gland disease | Seborrheic dermatitis | 0.133 | 6 | 2.06e-13 | 2.30e-12 ✓ sig. |
| Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies | Sebaceous gland disease | 0.071 | 1 | 8.39e-4 | 1.34e-3 ✓ sig. |
| Erythematosquamous dermatosis | Pityriasis rubra pilaris | 0.043 | 1 | 1.42e-3 | 2.04e-3 ✓ sig. |
| Pityriasis rubra pilaris | Seborrheic dermatitis | 0.026 | 1 | 2.39e-3 | 3.12e-3 ✓ sig. |