Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 500

6 diseases · 11 shared-gene connections
6 Diseases
7 Unique genes
0.352 Avg. similarity score
Peritoneal solitary fibrous tumor Most-connected disease (5 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Peritoneal solitary fibrous tumor 5 5 5
Dedifferentiated solitary fibrous tumor 4 4 3
Hemangiopericytoma 4 4 3
Hyper-immunoglobulin e syndrome 6, autosomal dominant, with recurrent infections 4 4 1
Meninges hemangiopericytoma 4 4 2
Tarp syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
STAT6 5 / 6 Dedifferentiated solitary fibrous tumor, Hemangiopericytoma, Hyper-immunoglobulin e syndrome 6, autosomal dominant, with recurrent infections, Meninges hemangiopericytoma and 1 more
NAB2 4 / 6 Dedifferentiated solitary fibrous tumor, Hemangiopericytoma, Meninges hemangiopericytoma, Peritoneal solitary fibrous tumor
RBM10 2 / 6 Peritoneal solitary fibrous tumor, Tarp syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Colorectal cancer
CTNNB1, TP53, RHOA
 KEGG 3 / 87 59.2× 1.26e-5 3.53e-4 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
STAT6, BCL6, TP53
 Reactome 3 / 108 47.7× 2.41e-5 6.09e-4 ✓ sig.
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
BCL6, TP53
 Reactome 2 / 14 245× 2.64e-5 6.54e-4 ✓ sig.
Fluid shear stress and atherosclerosis
CTNNB1, TP53, RHOA
 KEGG 3 / 141 36.5× 5.36e-5 1.15e-3 ✓ sig.
Wnt signaling pathway
CTNNB1, TP53, RHOA
 KEGG 3 / 174 29.6× 1.00e-4 1.90e-3 ✓ sig.
Pathways in cancer
STAT6, CTNNB1, TP53, RHOA
 KEGG 4 / 533 12.9× 1.21e-4 2.20e-3 ✓ sig.
Proteoglycans in cancer
CTNNB1, TP53, RHOA
 KEGG 3 / 204 25.2× 1.61e-4 2.77e-3 ✓ sig.
Thyroid cancer
CTNNB1, TP53
 KEGG 2 / 37 92.7× 1.92e-4 3.18e-3 ✓ sig.
Transcriptional Regulation by VENTX
CTNNB1, TP53
 Reactome 2 / 38 90.3× 2.03e-4 3.32e-3 ✓ sig.
Ovarian tumor domain proteases
TP53, RHOA
 Reactome 2 / 38 90.3× 2.03e-4 3.32e-3 ✓ sig.
Human cytomegalovirus infection
CTNNB1, TP53, RHOA
 KEGG 3 / 226 22.8× 2.18e-4 3.51e-3 ✓ sig.
Endometrial cancer
CTNNB1, TP53
 KEGG 2 / 59 58.2× 4.90e-4 6.59e-3 ✓ sig.
Basal cell carcinoma
CTNNB1, TP53
 KEGG 2 / 63 54.5× 5.59e-4 7.29e-3 ✓ sig.
Bacterial invasion of epithelial cells
CTNNB1, RHOA
 KEGG 2 / 78 44.0× 8.56e-4 1.01e-2 ✓ sig.
Regulation of TP53 Expression
TP53
 Reactome 1 / 2 858× 1.17e-3 1.27e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
isotype switching to IgE isotypes
STAT6, BCL6
 GO:0048289 2 / 3 1,780× 3.61e-7 3.69e-5 ✓ sig.
regulation of cell population proliferation
STAT6, BCL6, CTNNB1, TP53
 GO:0042127 4 / 201 53.1× 4.43e-7 4.40e-5 ✓ sig.
negative regulation of type 2 immune response
STAT6, BCL6
 GO:0002829 2 / 7 763× 2.52e-6 1.83e-4 ✓ sig.
cell-matrix adhesion
BCL6, CTNNB1, RHOA
 GO:0007160 3 / 105 76.3× 5.94e-6 3.63e-4 ✓ sig.
negative regulation of transcription by RNA polymerase II
RBM10, STAT6, BCL6, CTNNB1, TP53
 GO:0000122 5 / 1,002 13.3× 8.42e-6 4.78e-4 ✓ sig.
cell morphogenesis
BCL6, CTNNB1, RHOA
 GO:0000902 3 / 119 67.3× 8.65e-6 4.86e-4 ✓ sig.
regulation of T cell proliferation
BCL6, CTNNB1
 GO:0042129 2 / 17 314× 1.63e-5 7.92e-4 ✓ sig.
intracellular protein localization
BCL6, CTNNB1, TP53
 GO:0008104 3 / 194 41.3× 3.74e-5 1.48e-3 ✓ sig.
negative regulation of DNA-templated transcription
BCL6, NAB2, CTNNB1, TP53
 GO:0045892 4 / 631 16.9× 4.16e-5 1.60e-3 ✓ sig.
regulation of transcription by RNA polymerase II
STAT6, BCL6, CTNNB1, TP53, RHOA
 GO:0006357 5 / 1,602 8.3× 8.34e-5 2.70e-3 ✓ sig.
regulation of apoptotic process
BCL6, CTNNB1, TP53
 GO:0042981 3 / 254 31.5× 8.34e-5 2.70e-3 ✓ sig.
cell population proliferation
BCL6, CTNNB1, TP53
 GO:0008283 3 / 263 30.5× 9.25e-5 2.92e-3 ✓ sig.
T cell differentiation in thymus
CTNNB1, TP53
 GO:0033077 2 / 41 130× 9.79e-5 3.04e-3 ✓ sig.
embryonic organ development
CTNNB1, TP53
 GO:0048568 2 / 42 127× 1.03e-4 3.16e-3 ✓ sig.
neuroblast proliferation
CTNNB1, TP53
 GO:0007405 2 / 48 111× 1.35e-4 3.82e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Dedifferentiated solitary fibrous tumor Meninges hemangiopericytoma 0.667 2 8.34e-9 6.60e-8 ✓ sig.
Dedifferentiated solitary fibrous tumor Hemangiopericytoma 0.500 2 2.50e-8 1.87e-7 ✓ sig.
Hemangiopericytoma Meninges hemangiopericytoma 0.500 2 2.50e-8 1.87e-7 ✓ sig.
Dedifferentiated solitary fibrous tumor Peritoneal solitary fibrous tumor 0.333 2 8.34e-8 5.85e-7 ✓ sig.
Meninges hemangiopericytoma Peritoneal solitary fibrous tumor 0.333 2 8.34e-8 5.85e-7 ✓ sig.
Hemangiopericytoma Peritoneal solitary fibrous tumor 0.286 2 2.50e-7 1.65e-6 ✓ sig.
Dedifferentiated solitary fibrous tumor Hyper-immunoglobulin e syndrome 6, autosomal dominant, with recurrent infections 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Hyper-immunoglobulin e syndrome 6, autosomal dominant, with recurrent infections Meninges hemangiopericytoma 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Hemangiopericytoma Hyper-immunoglobulin e syndrome 6, autosomal dominant, with recurrent infections 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Hyper-immunoglobulin e syndrome 6, autosomal dominant, with recurrent infections Peritoneal solitary fibrous tumor 0.167 1 3.23e-4 6.41e-4 ✓ sig.
Peritoneal solitary fibrous tumor Tarp syndrome 0.167 1 3.23e-4 6.41e-4 ✓ sig.