Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 443

6 diseases · 7 shared-gene connections
6 Diseases
17 Unique genes
0.205 Avg. similarity score
Congenital microvillous atrophy Most-connected disease (3 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Congenital microvillous atrophy 3 3 1
Diarrhea 2, with microvillus atrophy 3 3 1
Intestinal disease 3 3 15
Microvillus inclusion disease 3 3 3
Diarrhea 12, with microvillus atrophy 1 1 1
Intestinal dysmotility syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
MYO5B 4 / 6 Congenital microvillous atrophy, Diarrhea 2, with microvillus atrophy, Intestinal disease, Microvillus inclusion disease
ANO1 2 / 6 Intestinal disease, Intestinal dysmotility syndrome
STX3 2 / 6 Diarrhea 12, with microvillus atrophy, Microvillus inclusion disease
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Toxoplasmosis
MAPK14, NOS2, PPIF
 KEGG 3 / 112 18.9× 4.88e-4 6.56e-3 ✓ sig.
activated TAK1 mediates p38 MAPK activation
MAPK14, NOD2
 Reactome 2 / 24 58.9× 5.11e-4 6.78e-3 ✓ sig.
Other interleukin signaling
STX3, STXBP2
 Reactome 2 / 24 58.9× 5.11e-4 6.78e-3 ✓ sig.
NOD1/2 Signaling Pathway
MAPK14, NOD2
 Reactome 2 / 36 39.2× 1.15e-3 1.27e-2 ✓ sig.
Tuberculosis
MAPK14, NOD2, NOS2
 KEGG 3 / 181 11.7× 1.96e-3 1.88e-2 ✓ sig.
SDK interactions
SDK2
 Reactome 1 / 2 353× 2.83e-3 2.44e-2 ✓ sig.
Peroxisomal protein import
ACOT8, NOS2
 Reactome 2 / 63 22.4× 3.50e-3 2.83e-2 ✓ sig.
Pathways of neurodegeneration - multiple diseases
MAPK14, DDIT3, NOS2, PPIF
 KEGG 4 / 480 5.9× 3.96e-3 3.11e-2 ✓ sig.
Inhibition of nitric oxide production
NOS2
 Reactome 1 / 3 235× 4.24e-3 3.26e-2 ✓ sig.
Nitric oxide stimulates guanylate cyclase
NOS2
 Reactome 1 / 3 235× 4.24e-3 3.26e-2 ✓ sig.
Pertussis
MAPK14, NOS2
 KEGG 2 / 78 18.1× 5.32e-3 3.80e-2 ✓ sig.
Leishmaniasis
MAPK14, NOS2
 KEGG 2 / 78 18.1× 5.32e-3 3.80e-2 ✓ sig.
Peroxisome
ACOT8, NOS2
 KEGG 2 / 83 17.0× 6.00e-3 4.10e-2 ✓ sig.
Prion disease
MAPK14, DDIT3, PPIF
 KEGG 3 / 275 7.7× 6.37e-3 4.28e-2 ✓ sig.
Chagas disease
MAPK14, NOS2
 KEGG 2 / 103 13.7× 9.11e-3 5.37e-2

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of interleukin-8 production
DDIT3, NOD2, NOS2
 GO:0032757 3 / 65 50.7× 2.64e-5 1.13e-3 ✓ sig.
regulation of cytokine production involved in inflammatory response
MAPK14, NOS2
 GO:1900015 2 / 11 200× 4.26e-5 1.63e-3 ✓ sig.
response to muramyl dipeptide
MAPK14, NOD2
 GO:0032495 2 / 13 169× 6.04e-5 2.13e-3 ✓ sig.
p38MAPK cascade
MAPK14, NOD2
 GO:0038066 2 / 26 84.6× 2.50e-4 5.95e-3 ✓ sig.
positive regulation of cardiac muscle cell proliferation
MAPK14, BMPR1A
 GO:0060045 2 / 32 68.7× 3.80e-4 7.89e-3 ✓ sig.
cell surface receptor protein serine/threonine kinase signaling pathway
MAPK14, BMPR1A
 GO:0007178 2 / 33 66.6× 4.05e-4 8.24e-3 ✓ sig.
cellular response to lipopolysaccharide
MAPK14, NOD2, NOS2
 GO:0071222 3 / 187 17.6× 6.05e-4 1.08e-2 ✓ sig.
cell redox homeostasis
DDIT3, NOS2
 GO:0045454 2 / 44 50.0× 7.21e-4 1.21e-2 ✓ sig.
intrinsic apoptotic signaling pathway in response to nitrosative stress
DDIT3
 GO:1990442 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.
detection of muramyl dipeptide
NOD2
 GO:0032498 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.
positive regulation of gamma-delta T cell activation
NOD2
 GO:0046645 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.
neural plate mediolateral regionalization
BMPR1A
 GO:0021998 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.
paraxial mesoderm structural organization
BMPR1A
 GO:0048352 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.
neural plate pattern specification
BMPR1A
 GO:0060896 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.
positive regulation of cardiac ventricle development
BMPR1A
 GO:1904414 1 / 1 1,099× 9.10e-4 1.39e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Congenital microvillous atrophy Diarrhea 2, with microvillus atrophy 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Congenital microvillous atrophy Microvillus inclusion disease 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Diarrhea 12, with microvillus atrophy Microvillus inclusion disease 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Diarrhea 2, with microvillus atrophy Microvillus inclusion disease 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Congenital microvillous atrophy Intestinal disease 0.063 1 9.68e-4 1.50e-3 ✓ sig.
Diarrhea 2, with microvillus atrophy Intestinal disease 0.063 1 9.68e-4 1.50e-3 ✓ sig.
Intestinal disease Intestinal dysmotility syndrome 0.063 1 9.68e-4 1.50e-3 ✓ sig.