Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 439
6
Diseases
21
Unique genes
0.229
Avg. similarity score
Asperger syndrome
Most-connected disease (5 links)
Disease
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Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Asperger syndrome
Epileptic encephalopathy with global cerebral demyelination
Epileptic encephalopathy, early infantile, 39
Hypomyelination, global cerebral
Behavior disorders
Fatigue syndrome
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Asperger syndrome | 5 | 5 | 9 |
| Epileptic encephalopathy with global cerebral demyelination | 3 | 3 | 1 |
| Epileptic encephalopathy, early infantile, 39 | 3 | 3 | 1 |
| Hypomyelination, global cerebral | 3 | 3 | 1 |
| Behavior disorders | 2 | 2 | 1 |
| Fatigue syndrome | 2 | 2 | 14 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| SLC25A12 | 4 / 6 | Asperger syndrome, Epileptic encephalopathy with global cerebral demyelination, Epileptic encephalopathy, early infantile, 39, Hypomyelination, global cerebral |
| SLC6A4 | 3 / 6 | Asperger syndrome, Behavior disorders, Fatigue syndrome |
| DISC1 | 2 / 6 | Asperger syndrome, Fatigue syndrome |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Serotonin clearance from the synaptic cleft | Reactome | 1 / 1 | 572× | 1.75e-3 | 1.73e-2 ✓ sig. |
| Graft-versus-host disease | KEGG | 2 / 45 | 25.4× | 2.76e-3 | 2.40e-2 ✓ sig. |
| Axon guidance | KEGG | 3 / 183 | 9.4× | 3.78e-3 | 3.00e-2 ✓ sig. |
| Antigen processing and presentation | KEGG | 2 / 81 | 14.1× | 8.68e-3 | 5.22e-2 |
| Aspartate and asparagine metabolism | Reactome | 1 / 12 | 47.7× | 2.08e-2 | 8.77e-2 |
| The activation of arylsulfatases | Reactome | 1 / 13 | 44.0× | 2.25e-2 | 9.16e-2 |
| Elevation of cytosolic Ca2+ levels | Reactome | 1 / 13 | 44.0× | 2.25e-2 | 9.16e-2 |
| Keratinization | Reactome | 2 / 152 | 7.5× | 2.86e-2 | 1.05e-1 |
| Cell adhesion molecules | KEGG | 2 / 160 | 7.1× | 3.14e-2 | 1.11e-1 |
| Translocation of ZAP-70 to Immunological synapse | Reactome | 1 / 19 | 30.1× | 3.27e-2 | 1.14e-1 |
| Effects of PIP2 hydrolysis | Reactome | 1 / 20 | 28.6× | 3.44e-2 | 1.17e-1 |
| EPHA-mediated growth cone collapse | Reactome | 1 / 20 | 28.6× | 3.44e-2 | 1.17e-1 |
| DAP12 interactions | Reactome | 1 / 21 | 27.2× | 3.61e-2 | 1.20e-1 |
| Phosphorylation of CD3 and TCR zeta chains | Reactome | 1 / 22 | 26.0× | 3.78e-2 | 1.23e-1 |
| EPH-Ephrin signaling | Reactome | 1 / 22 | 26.0× | 3.78e-2 | 1.23e-1 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of cell-matrix adhesion | GO:0001954 | 2 / 27 | 65.9× | 4.15e-4 | 8.41e-3 ✓ sig. |
| regulation of postsynapse organization | GO:0099175 | 2 / 34 | 52.3× | 6.60e-4 | 1.14e-2 ✓ sig. |
| positive regulation of BMP signaling pathway | GO:0030513 | 2 / 40 | 44.5× | 9.14e-4 | 1.39e-2 ✓ sig. |
| positive regulation of ion transmembrane transporter activity | GO:0032414 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| diadenosine triphosphate catabolic process | GO:0015964 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| positive regulation of serotonin secretion | GO:0014064 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| regulation of thalamus size | GO:0090067 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| tricuspid valve development | GO:0003175 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| embryonic heart tube elongation | GO:0036306 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| lateral mesoderm formation | GO:0048370 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| epinephrine secretion | GO:0048242 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| negative regulation of nervous system development | GO:0051961 | 1 / 1 | 890× | 1.12e-3 | 1.55e-2 ✓ sig. |
| regulation of protein autophosphorylation | GO:0031952 | 1 / 2 | 445× | 2.25e-3 | 2.24e-2 ✓ sig. |
| pulmonary vein morphogenesis | GO:0060577 | 1 / 2 | 445× | 2.25e-3 | 2.24e-2 ✓ sig. |
| negative regulation of cerebellar granule cell precursor proliferation | GO:0021941 | 1 / 2 | 445× | 2.25e-3 | 2.24e-2 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Asperger syndrome | Fatigue syndrome | 0.091 | 2 | 2.72e-5 | 1.41e-4 ✓ sig. |
| Epileptic encephalopathy with global cerebral demyelination | Epileptic encephalopathy, early infantile, 39 | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Epileptic encephalopathy with global cerebral demyelination | Hypomyelination, global cerebral | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Epileptic encephalopathy, early infantile, 39 | Hypomyelination, global cerebral | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Asperger syndrome | Behavior disorders | 0.100 | 1 | 5.81e-4 | 1.00e-3 ✓ sig. |
| Asperger syndrome | Epileptic encephalopathy, early infantile, 39 | 0.100 | 1 | 5.81e-4 | 1.00e-3 ✓ sig. |
| Asperger syndrome | Hypomyelination, global cerebral | 0.100 | 1 | 5.81e-4 | 1.00e-3 ✓ sig. |
| Asperger syndrome | Epileptic encephalopathy with global cerebral demyelination | 0.100 | 1 | 5.81e-4 | 1.00e-3 ✓ sig. |
| Behavior disorders | Fatigue syndrome | 0.067 | 1 | 9.04e-4 | 1.41e-3 ✓ sig. |