Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 120

11 diseases · 17 shared-gene connections
11 Diseases
35 Unique genes
0.152 Avg. similarity score
Colchicine resistance Most-connected disease (6 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Colchicine resistance 6 6 1
Familial mediterranean fever 6 6 2
Antisocial personality disorder 5 5 4
Orthostatic hypotension 4 4 3
Congenital dyserythropoietic anemia 3 3 10
Hematologic neoplasms 3 3 5
Hyperpituitarism 3 3 15
Brunner syndrome 1 1 1
Dopamine beta-hydroxy­lase deficiency 1 1 2
Separation anxiety disorder 1 1 1
anemia, congenital dyserythropoietic, type 1a 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
ABCB1 7 / 11 Antisocial personality disorder, Colchicine resistance, Congenital dyserythropoietic anemia, Familial mediterranean fever and 3 more
CDAN1 2 / 11 anemia, congenital dyserythropoietic, type 1a, Congenital dyserythropoietic anemia
DRD4 2 / 11 Antisocial personality disorder, Separation anxiety disorder
HSPA5 2 / 11 Dopamine beta-hydroxy­lase deficiency, Hematologic neoplasms
MAOA 2 / 11 Antisocial personality disorder, Brunner syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Defective MAOA causes Brunner syndrome (BRUNS)
MAOA
 Reactome 1 / 1 343× 2.91e-3 3.01e-2 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
MAOA, OPRD1, OPRM1
 Reactome 3 / 108 9.5× 3.75e-3 3.60e-2 ✓ sig.
Tyrosine metabolism
MAOA, DBH
 KEGG 2 / 36 19.1× 4.88e-3 4.32e-2 ✓ sig.
G alpha (i) signalling events
DRD4, HTR1B, OPRD1, OPRM1
 Reactome 4 / 249 5.5× 5.70e-3 4.78e-2 ✓ sig.
Enzymatic degradation of Dopamine by monoamine oxidase
MAOA
 Reactome 1 / 2 172× 5.82e-3 4.84e-2 ✓ sig.
Metabolism of serotonin
MAOA
 Reactome 1 / 2 172× 5.82e-3 4.84e-2 ✓ sig.
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
MAOA
 Reactome 1 / 2 172× 5.82e-3 4.84e-2 ✓ sig.
Tryptophan metabolism
MAOA, GCDH
 KEGG 2 / 42 16.3× 6.60e-3 5.27e-2
Mitotic Telophase/Cytokinesis
KIF23
 Reactome 1 / 3 114× 8.72e-3 6.31e-2
Enzymatic degradation of dopamine by COMT
MAOA
 Reactome 1 / 3 114× 8.72e-3 6.31e-2
IRE1alpha activates chaperones
HSPA5
 Reactome 1 / 3 114× 8.72e-3 6.31e-2
Opioid Signalling
OPRM1
 Reactome 1 / 3 114× 8.72e-3 6.31e-2
Catecholamine biosynthesis
DBH
 Reactome 1 / 4 85.8× 1.16e-2 7.50e-2
ATF6 (ATF6-alpha) activates chaperones
HSPA5
 Reactome 1 / 4 85.8× 1.16e-2 7.50e-2
IRAK4 deficiency (TLR5)
IRAK4
 Reactome 1 / 4 85.8× 1.16e-2 7.50e-2

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
behavioral response to ethanol
DRD4, DBH, OPRM1
 GO:0048149 3 / 10 160× 7.16e-7 6.34e-5 ✓ sig.
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
DRD4, HTR1B, OPRD1, OPRM1
 GO:0007187 4 / 54 39.5× 3.05e-6 2.02e-4 ✓ sig.
cellular response to alkaloid
ABCB1, HTR1B
 GO:0071312 2 / 6 178× 5.09e-5 1.82e-3 ✓ sig.
fear response
DRD4, DBH
 GO:0042596 2 / 8 133× 9.48e-5 2.90e-3 ✓ sig.
G protein-coupled opioid receptor signaling pathway
OPRD1, OPRM1
 GO:0038003 2 / 9 119× 1.22e-4 3.51e-3 ✓ sig.
mitotic spindle midzone assembly
KIF23, RACGAP1
 GO:0051256 2 / 11 97.1× 1.85e-4 4.79e-3 ✓ sig.
dopamine catabolic process
MAOA, DBH
 GO:0042420 2 / 11 97.1× 1.85e-4 4.79e-3 ✓ sig.
cerebellar Purkinje cell layer development
HSPA5, FAIM2
 GO:0021680 2 / 12 89.0× 2.22e-4 5.43e-3 ✓ sig.
erythrocyte differentiation
CDIN1, RACGAP1, KLF1
 GO:0030218 3 / 65 24.6× 2.43e-4 5.79e-3 ✓ sig.
maternal behavior
DBH, BRINP1
 GO:0042711 2 / 14 76.3× 3.06e-4 6.81e-3 ✓ sig.
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
HTR1B, OPRD1, OPRM1
 GO:0007193 3 / 73 21.9× 3.42e-4 7.35e-3 ✓ sig.
vasoconstriction
HTR1B, DBH
 GO:0042310 2 / 18 59.3× 5.12e-4 9.70e-3 ✓ sig.
hematopoietic stem cell proliferation
ETV6, MECOM
 GO:0071425 2 / 25 42.7× 9.95e-4 1.50e-2 ✓ sig.
acyl-CoA metabolic process
GCDH, ACSM2A
 GO:0006637 2 / 28 38.1× 1.25e-3 1.73e-2 ✓ sig.
interleukin-1-mediated signaling pathway
IRAK4, IL1R1
 GO:0070498 2 / 28 38.1× 1.25e-3 1.73e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Colchicine resistance Familial mediterranean fever 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Colchicine resistance Orthostatic hypotension 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Antisocial personality disorder Brunner syndrome 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Antisocial personality disorder Separation anxiety disorder 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Antisocial personality disorder Colchicine resistance 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Colchicine resistance Hematologic neoplasms 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Familial mediterranean fever Orthostatic hypotension 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Antisocial personality disorder Familial mediterranean fever 0.167 1 5.19e-4 1.04e-3 ✓ sig.
Dopamine beta-hydroxy­lase deficiency Hematologic neoplasms 0.143 1 6.49e-4 1.22e-3 ✓ sig.
Familial mediterranean fever Hematologic neoplasms 0.143 1 6.49e-4 1.22e-3 ✓ sig.
anemia, congenital dyserythropoietic, type 1a Congenital dyserythropoietic anemia 0.091 1 6.49e-4 1.22e-3 ✓ sig.
Colchicine resistance Congenital dyserythropoietic anemia 0.091 1 6.49e-4 1.22e-3 ✓ sig.
Antisocial personality disorder Orthostatic hypotension 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Colchicine resistance Hyperpituitarism 0.063 1 9.74e-4 1.64e-3 ✓ sig.
Congenital dyserythropoietic anemia Familial mediterranean fever 0.083 1 1.30e-3 2.04e-3 ✓ sig.
Familial mediterranean fever Hyperpituitarism 0.059 1 1.95e-3 2.81e-3 ✓ sig.
Hyperpituitarism Orthostatic hypotension 0.056 1 2.92e-3 3.87e-3 ✓ sig.