Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	9991
Gene name	Polypyrimidine tract binding protein 3
Gene symbol	PTBP3
Synonyms (NCBI Gene)	ROD1
Chromosome	9
Chromosome location	9q32
Summary	The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gen

152

Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022729	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT024160	hsa-miR-221-3p	Sequencing	20371350
MIRT030890	hsa-miR-21-5p	Microarray	18591254
MIRT048115	hsa-miR-197-3p	CLASH	23622248
MIRT047996	hsa-miR-30c-5p	CLASH	23622248
MIRT042966	hsa-miR-324-3p	CLASH	23622248
MIRT041782	hsa-miR-484	CLASH	23622248
MIRT036365	hsa-miR-1229-3p	CLASH	23622248
MIRT054186	hsa-miR-210-3p	MicroarrayqRT-PCRWestern blot	23024754
MIRT722100	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT722099	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT722098	hsa-miR-607	HITS-CLIP	19536157
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	19536157
MIRT630581	hsa-miR-4496	HITS-CLIP	19536157
MIRT630580	hsa-miR-1323	HITS-CLIP	19536157
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	19536157
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT323959	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT323960	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT630578	hsa-miR-4268	HITS-CLIP	19536157
MIRT630577	hsa-miR-4448	HITS-CLIP	19536157
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT106872	hsa-miR-181d-5p	HITS-CLIP	23824327
MIRT106868	hsa-miR-181a-5p	HITS-CLIP	23824327
MIRT106870	hsa-miR-181c-5p	HITS-CLIP	23824327
MIRT106869	hsa-miR-181b-5p	HITS-CLIP	23824327
MIRT106875	hsa-miR-4262	HITS-CLIP	23824327
MIRT666783	hsa-miR-8485	HITS-CLIP	23824327
MIRT666782	hsa-miR-603	HITS-CLIP	23824327
MIRT666781	hsa-miR-3941	HITS-CLIP	23824327
MIRT666780	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566243	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566242	hsa-miR-3714	PAR-CLIP	20371350
MIRT566241	hsa-miR-3910	PAR-CLIP	20371350
MIRT566240	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT566239	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566238	hsa-miR-4672	PAR-CLIP	20371350
MIRT555177	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT555176	hsa-miR-4728-3p	PAR-CLIP	21572407
MIRT555175	hsa-miR-8060	PAR-CLIP	21572407
MIRT555174	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT555173	hsa-miR-891b	PAR-CLIP	21572407
MIRT555172	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT555171	hsa-miR-548v	PAR-CLIP	21572407
MIRT024160	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT555170	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT106878	hsa-miR-7154-5p	PAR-CLIP	21572407
MIRT555169	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT555168	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT534943	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT534942	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT534941	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT534940	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT534939	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT534938	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT534937	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT364362	hsa-miR-205-3p	PAR-CLIP	22012620
MIRT393731	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT735604	hsa-miR-29a-3p	qRT-PCR	32117452
MIRT722100	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT722099	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT722098	hsa-miR-607	HITS-CLIP	19536157
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	19536157
MIRT630581	hsa-miR-4496	HITS-CLIP	19536157
MIRT630580	hsa-miR-1323	HITS-CLIP	19536157
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	19536157
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT323959	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT323960	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT630578	hsa-miR-4268	HITS-CLIP	19536157
MIRT630577	hsa-miR-4448	HITS-CLIP	19536157
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT106872	hsa-miR-181d-5p	HITS-CLIP	23824327
MIRT106868	hsa-miR-181a-5p	HITS-CLIP	23824327
MIRT106870	hsa-miR-181c-5p	HITS-CLIP	23824327
MIRT106869	hsa-miR-181b-5p	HITS-CLIP	23824327
MIRT106875	hsa-miR-4262	HITS-CLIP	23824327
MIRT666783	hsa-miR-8485	HITS-CLIP	23824327
MIRT666782	hsa-miR-603	HITS-CLIP	23824327
MIRT666781	hsa-miR-3941	HITS-CLIP	23824327
MIRT666780	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566243	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566242	hsa-miR-3714	PAR-CLIP	20371350
MIRT566241	hsa-miR-3910	PAR-CLIP	20371350
MIRT566240	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT566239	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566238	hsa-miR-4672	PAR-CLIP	20371350
MIRT555177	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT555176	hsa-miR-4728-3p	PAR-CLIP	21572407
MIRT555175	hsa-miR-8060	PAR-CLIP	21572407
MIRT555174	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT555173	hsa-miR-891b	PAR-CLIP	21572407
MIRT555172	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT555171	hsa-miR-548v	PAR-CLIP	21572407
MIRT024160	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT555170	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT106878	hsa-miR-7154-5p	PAR-CLIP	21572407
MIRT555169	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT555168	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT534943	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT534942	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT534941	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT534940	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT534939	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT534938	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT534937	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT364362	hsa-miR-205-3p	PAR-CLIP	22012620
MIRT393731	hsa-miR-3613-3p	PAR-CLIP	22012620

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	10207106
GO:0003729	Function	MRNA binding	IBA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	10207106
GO:0030154	Process	Cell differentiation	IEA
GO:0033119	Process	Negative regulation of RNA splicing	IDA	18335065
GO:0033119	Process	Negative regulation of RNA splicing	IEA
GO:0043249	Process	Erythrocyte maturation	IEA
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0045595	Process	Regulation of cell differentiation	IEA

MIM	HGNC	e!Ensembl
607527	10253	ENSG00000119314

O95758

Protein name

Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1)

Protein function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentia

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11835	RRM_8	171 → 258	RRM-like domain	Domain
PF13893	RRM_5	329 → 454		Domain
PF13893	RRM_5	472 → 552		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in several hematopoietic cell lines examined. {ECO:0000269|PubMed:10207106}.

Sequence

MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRV
LHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPH
LRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSP
VLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALD
GQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGI
ISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVL
LVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRL
YGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLS
NIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGEN
HHLRVSFSKSTI

Sequence length

552

Interactions

View interactions

PTBP3 (polypyrimidine tract binding protein 3)