Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9988
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin D binding myb like transcription factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DMTF1
Synonyms (NCBI Gene) Gene synonyms aliases
DMP1, DMTF, MRUL, hDMP1
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q21.12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathwa
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002946 hsa-miR-15a-5p Luciferase reporter assay 15131085
MIRT027072 hsa-miR-103a-3p Sequencing 20371350
MIRT030806 hsa-miR-21-5p Microarray 18591254
MIRT031727 hsa-miR-16-5p Sequencing 20371350
MIRT002946 hsa-miR-15a-5p Reporter assay 15131085
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IEA
GO:0003700 Function DNA-binding transcription factor activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608491 14603 ENSG00000135164
Protein
UniProt ID Q9Y222
Protein name Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1)
Protein function Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 ma
PDB 2LLK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00249 Myb_DNA-binding 273 329 Myb-like DNA-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala,
Sequence
MSTVEEDSDTVTVETVNSVTLTQDTEGNLILHCPQNEADEIDSEDSIEPPHKRLCLSSED
DQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDEVTEGTVTQIQILQNEQLDEIS
PLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDA
TEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRI
KHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIV
TQGVSWAAVAERVGTRSEKQCRSKWLNYL
NWKQSGGTEWTKEDEINLILRIAELDVADEN
DINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPTLL
ENKSGSGVPNSNTNSSVQHVQIRVARLEDNTAISSSPMAALQIPVQITHVSSADSPATVD
SETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPAS
PEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDF
PEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDL
KQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPL
TTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH
Sequence length 760
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
30285260, 26198764
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 20351715 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 23045280, 33120969
Carcinoma Non Small Cell Lung Associate 33120969
Carcinoma Non Small Cell Lung Stimulate 33123591
Colorectal Neoplasms Associate 30592263
Neoplasms Inhibit 33367929, 36323260
Neoplasms Associate 34291726
Obesity Associate 37800791
Prostatic Neoplasms Associate 37143720
Urinary Bladder Neoplasms Associate 37800791