Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	9963
Gene name	Solute carrier family 23 member 1
Gene symbol	SLC23A1
Synonyms (NCBI Gene)	SLC23A2SVCT1YSPL3
Chromosome	5
Chromosome location	5q31.2
Summary	The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial su

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miRTarBase ID	miRNA	Experiments	Reference
MIRT569658	hsa-miR-3662	PAR-CLIP	20371350
MIRT569657	hsa-miR-224-3p	PAR-CLIP	20371350
MIRT569656	hsa-miR-522-3p	PAR-CLIP	20371350
MIRT569655	hsa-miR-5009-3p	PAR-CLIP	20371350
MIRT569653	hsa-miR-3650	PAR-CLIP	20371350
MIRT569654	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569652	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT534243	hsa-miR-4781-5p	PAR-CLIP	22012620
MIRT534242	hsa-miR-5193	PAR-CLIP	22012620
MIRT534241	hsa-miR-660-3p	PAR-CLIP	22012620
MIRT534240	hsa-miR-3653-5p	PAR-CLIP	22012620
MIRT534239	hsa-miR-4321	PAR-CLIP	22012620
MIRT497593	hsa-miR-1179	PAR-CLIP	22291592
MIRT497592	hsa-miR-877-3p	PAR-CLIP	22291592
MIRT497591	hsa-miR-1185-5p	PAR-CLIP	22291592
MIRT497590	hsa-miR-3679-5p	PAR-CLIP	22291592
MIRT497589	hsa-miR-3605-5p	PAR-CLIP	22291592
MIRT497588	hsa-miR-6881-3p	PAR-CLIP	22291592
MIRT497587	hsa-miR-526b-5p	PAR-CLIP	22291592
MIRT497586	hsa-miR-203a-3p	PAR-CLIP	22291592
MIRT497585	hsa-miR-3915	PAR-CLIP	22291592
MIRT497584	hsa-miR-1224-5p	PAR-CLIP	22291592
MIRT497583	hsa-miR-4689	PAR-CLIP	22291592
MIRT497582	hsa-miR-6858-5p	PAR-CLIP	22291592
MIRT497581	hsa-miR-510-3p	PAR-CLIP	22291592
MIRT467873	hsa-miR-562	PAR-CLIP	23592263
MIRT467872	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT467872	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT467871	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT467869	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT467870	hsa-miR-3649	PAR-CLIP	23592263
MIRT569658	hsa-miR-3662	PAR-CLIP	20371350
MIRT569657	hsa-miR-224-3p	PAR-CLIP	20371350
MIRT569656	hsa-miR-522-3p	PAR-CLIP	20371350
MIRT569655	hsa-miR-5009-3p	PAR-CLIP	20371350
MIRT569653	hsa-miR-3650	PAR-CLIP	20371350
MIRT569654	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569652	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT534243	hsa-miR-4781-5p	PAR-CLIP	22012620
MIRT534242	hsa-miR-5193	PAR-CLIP	22012620
MIRT534241	hsa-miR-660-3p	PAR-CLIP	22012620
MIRT534240	hsa-miR-3653-5p	PAR-CLIP	22012620
MIRT534239	hsa-miR-4321	PAR-CLIP	22012620
MIRT497593	hsa-miR-1179	PAR-CLIP	22291592
MIRT497592	hsa-miR-877-3p	PAR-CLIP	22291592
MIRT497591	hsa-miR-1185-5p	PAR-CLIP	22291592
MIRT497590	hsa-miR-3679-5p	PAR-CLIP	22291592
MIRT497589	hsa-miR-3605-5p	PAR-CLIP	22291592
MIRT497588	hsa-miR-6881-3p	PAR-CLIP	22291592
MIRT497587	hsa-miR-526b-5p	PAR-CLIP	22291592
MIRT497586	hsa-miR-203a-3p	PAR-CLIP	22291592
MIRT497585	hsa-miR-3915	PAR-CLIP	22291592
MIRT497584	hsa-miR-1224-5p	PAR-CLIP	22291592
MIRT497583	hsa-miR-4689	PAR-CLIP	22291592
MIRT497582	hsa-miR-6858-5p	PAR-CLIP	22291592
MIRT497581	hsa-miR-510-3p	PAR-CLIP	22291592
MIRT467873	hsa-miR-562	PAR-CLIP	23592263
MIRT467872	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT467872	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT467871	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT467869	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT467870	hsa-miR-3649	PAR-CLIP	23592263
MIRT1354608	hsa-miR-1207-5p	CLIP-seq
MIRT1354609	hsa-miR-1305	CLIP-seq
MIRT1354610	hsa-miR-1343	CLIP-seq
MIRT1354611	hsa-miR-2115	CLIP-seq
MIRT1354612	hsa-miR-3074-5p	CLIP-seq
MIRT1354613	hsa-miR-3124-3p	CLIP-seq
MIRT1354614	hsa-miR-3155	CLIP-seq
MIRT1354615	hsa-miR-3155b	CLIP-seq
MIRT1354616	hsa-miR-3167	CLIP-seq
MIRT1354617	hsa-miR-3690	CLIP-seq
MIRT1354618	hsa-miR-4254	CLIP-seq
MIRT1354619	hsa-miR-4278	CLIP-seq
MIRT1354620	hsa-miR-4290	CLIP-seq
MIRT1354621	hsa-miR-4446-3p	CLIP-seq
MIRT1354622	hsa-miR-4474-5p	CLIP-seq
MIRT1354623	hsa-miR-4492	CLIP-seq
MIRT1354624	hsa-miR-4498	CLIP-seq
MIRT1354625	hsa-miR-4505	CLIP-seq
MIRT1354626	hsa-miR-4688	CLIP-seq
MIRT1354627	hsa-miR-4763-3p	CLIP-seq
MIRT1354628	hsa-miR-484	CLIP-seq
MIRT1354629	hsa-miR-486-3p	CLIP-seq
MIRT1354630	hsa-miR-491-3p	CLIP-seq
MIRT1354631	hsa-miR-516a-3p	CLIP-seq
MIRT1354632	hsa-miR-586	CLIP-seq
MIRT1354633	hsa-miR-656	CLIP-seq
MIRT1354634	hsa-miR-762	CLIP-seq
MIRT1354635	hsa-miR-876-5p	CLIP-seq
MIRT1354636	hsa-miR-889	CLIP-seq
MIRT1354612	hsa-miR-3074-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147, 23599041, 25416956, 29892012, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IDA	10631088, 36749388
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10395795
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IDA	18094143
GO:0006814	Process	Sodium ion transport	IEA
GO:0007420	Process	Brain development	IEA
GO:0007420	Process	Brain development	ISS
GO:0008520	Function	L-ascorbate:sodium symporter activity	IDA	10556483
GO:0008520	Function	L-ascorbate:sodium symporter activity	IDA	10556483, 10631088, 11895172, 15993839, 18094143, 36749388
GO:0008520	Function	L-ascorbate:sodium symporter activity	IEA
GO:0009636	Process	Response to toxic substance	IDA	17575980
GO:0009925	Component	Basal plasma membrane	IEA
GO:0015081	Function	Sodium ion transmembrane transporter activity	IDA	18094143
GO:0015143	Function	Urate transmembrane transporter activity	IDA	36749388
GO:0015143	Function	Urate transmembrane transporter activity	IEA
GO:0015205	Function	Nucleobase transmembrane transporter activity	TAS	10395795
GO:0015229	Function	L-ascorbic acid transmembrane transporter activity	IBA
GO:0015229	Function	L-ascorbic acid transmembrane transporter activity	IDA	10631088, 11895172, 18247577, 18417304, 19216494
GO:0015229	Function	L-ascorbic acid transmembrane transporter activity	IEA
GO:0015229	Function	L-ascorbic acid transmembrane transporter activity	TAS
GO:0015293	Function	Symporter activity	IEA
GO:0015747	Process	Urate transport	IEA
GO:0015851	Process	Nucleobase transport	TAS	10395795
GO:0015882	Process	L-ascorbic acid transmembrane transport	IDA	10556483
GO:0015882	Process	L-ascorbic acid transmembrane transport	IDA	10556483, 10631088, 11895172, 18247577, 18417304, 19216494
GO:0015882	Process	L-ascorbic acid transmembrane transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IBA
GO:0016324	Component	Apical plasma membrane	IDA	15993839, 18094143, 18247577, 18417304, 19216494
GO:0019852	Process	L-ascorbic acid metabolic process	TAS
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030324	Process	Lung development	IEA
GO:0033300	Function	Dehydroascorbic acid transmembrane transporter activity	IMP	18247577
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0043229	Component	Intracellular organelle	IDA	15993839
GO:0055085	Process	Transmembrane transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070837	Process	Dehydroascorbic acid transport	IMP	18247577

MIM	HGNC	e!Ensembl
603790	10974	ENSG00000170482

Q9UHI7

Protein name

Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)

Protein function

Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucle

PDB

8JEW , 8JEZ , 8JF0 , 8JF1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00860	Xan_ur_permease	43 → 477	Permease family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus. {ECO:0000269|PubMed:10556483}.

Sequence

MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTI
AVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKA
ILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALL
NYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRW
GKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIA
PWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGI
FTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALF
SSLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPG
AINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSS
LKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV

Sequence length

598

Interactions

View interactions

	KEGG		Reactome
	Vitamin digestion and absorption		Vitamin C (ascorbate) metabolism

SLC23A1 (solute carrier family 23 member 1)