Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9957
Gene name Gene Name - the full gene name approved by the HGNC.
Heparan sulfate-glucosamine 3-sulfotransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HS3ST1
Synonyms (NCBI Gene) Gene synonyms aliases
3OST, 3OST1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p15.33
Summary Summary of gene provided in NCBI Entrez Gene.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs16881446 T>C Risk-factor Intron variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT715339 hsa-miR-6801-3p HITS-CLIP 19536157
MIRT715338 hsa-miR-6810-3p HITS-CLIP 19536157
MIRT627148 hsa-miR-6075 HITS-CLIP 19536157
MIRT715337 hsa-miR-4772-3p HITS-CLIP 19536157
MIRT715336 hsa-miR-4313 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005796 Component Golgi lumen TAS
GO:0006024 Process Glycosaminoglycan biosynthetic process TAS
GO:0008146 Function Sulfotransferase activity TAS 9988767
GO:0008467 Function [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603244 5194 ENSG00000002587
Protein
UniProt ID O14792
Protein name Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1)
Protein function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768). Catalyzes the rate limiting step in
PDB 1ZRH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00685 Sulfotransfer_1 54 298 Sulfotransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. {ECO:0000269|PubMed:9988767}.
Sequence
Sequence length 307
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycosaminoglycan biosynthesis - heparan sulfate / heparin   HS-GAG biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 15266341
Unknown
Disease term Disease name Evidence References Source
Ankylosing Spondylitis Ankylosing Spondylitis GWAS
Crohn Disease Crohn Disease GWAS
Restless Legs Syndrome Restless Legs Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 33419465, 33627629
Brain Diseases Associate 33419465
Carcinogenesis Associate 35909476
Carcinoma Non Small Cell Lung Stimulate 35909476
Chondrosarcoma Associate 19812376
Endometriosis Associate 37555920
Glioma Associate 29104277
Hypoxia Associate 35309336
Inflammation Associate 35309336
Neoplasms Associate 22025563, 35909476