HS3ST3A1 (heparan sulfate-glucosamine 3-sulfotransferase 3A1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID 9955
Gene name Heparan sulfate-glucosamine 3-sulfotransferase 3A1
Gene symbol HS3ST3A1
Synonyms (NCBI Gene)
3-OST-3A3OST3A1
Chromosome 17
Chromosome location 17p12
Summary Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme
miRNA miRNA information provided by mirtarbase database.
3
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all (3)
miRTarBase ID miRNA Experiments Reference
MIRT049250 hsa-miR-92a-3p CLASH 23622248
MIRT1054936 hsa-miR-3613-3p CLIP-seq
MIRT1054937 hsa-miR-4311 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0001658 Process Branching involved in ureteric bud morphogenesis IEA
GO:0005794 Component Golgi apparatus IEA
GO:0006024 Process Glycosaminoglycan biosynthetic process IDA 9988768, 15304505
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
604057 5196 ENSG00000153976
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y663
Protein name Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1) (3-OST-3A) (Heparan sulfate 3-O-sulfotransferase 3A1) (h3-OST-3A)
Protein function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:10608887, PubMe
PDB 1T8T , 1T8U , 6XKG , 6XL8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00685 Sulfotransfer_1 152 → 399 Sulfotransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney. {ECO:0000269|PubMed:9988767}.
Sequence
Sequence length 406
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways
  KEGG  Reactome
  Glycosaminoglycan biosynthesis - heparan sulfate / heparin   HS-GAG biosynthesis