Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	9953
Gene name	Heparan sulfate-glucosamine 3-sulfotransferase 3B1
Gene symbol	HS3ST3B1
Synonyms (NCBI Gene)	3-OST-3B3OST3B1h3-OST-3B
Chromosome	17
Chromosome location	17p12
Summary	The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specific

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026649	hsa-miR-192-5p	Microarray	19074876
MIRT030947	hsa-miR-21-5p	Sequencing	20371350
MIRT657278	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT657277	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT657276	hsa-miR-548ax	HITS-CLIP	23824327
MIRT657274	hsa-miR-5585-5p	HITS-CLIP	23824327
MIRT657275	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT657273	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT657272	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT657271	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT506948	hsa-miR-132-3p	PAR-CLIP	22012620
MIRT506947	hsa-miR-212-3p	PAR-CLIP	22012620
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	22012620
MIRT506945	hsa-miR-4477a	PAR-CLIP	22012620
MIRT506948	hsa-miR-132-3p	PAR-CLIP	23446348
MIRT506947	hsa-miR-212-3p	PAR-CLIP	23446348
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT506945	hsa-miR-4477a	PAR-CLIP	23446348
MIRT506948	hsa-miR-132-3p	PAR-CLIP	23446348
MIRT506947	hsa-miR-212-3p	PAR-CLIP	23446348
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT506945	hsa-miR-4477a	PAR-CLIP	23446348
MIRT506948	hsa-miR-132-3p	PAR-CLIP	26701625
MIRT506948	hsa-miR-132-3p	PAR-CLIP	26701625
MIRT506948	hsa-miR-132-3p	PAR-CLIP	26701625
MIRT506948	hsa-miR-132-3p	PAR-CLIP	26701625
MIRT506948	hsa-miR-132-3p	PAR-CLIP	26701625
MIRT506948	hsa-miR-132-3p	PAR-CLIP	26701625
MIRT506947	hsa-miR-212-3p	PAR-CLIP	26701625
MIRT506947	hsa-miR-212-3p	PAR-CLIP	26701625
MIRT506947	hsa-miR-212-3p	PAR-CLIP	26701625
MIRT506947	hsa-miR-212-3p	PAR-CLIP	26701625
MIRT506947	hsa-miR-212-3p	PAR-CLIP	26701625
MIRT506947	hsa-miR-212-3p	PAR-CLIP	26701625
MIRT506945	hsa-miR-4477a	PAR-CLIP	26701625
MIRT506945	hsa-miR-4477a	PAR-CLIP	26701625
MIRT506945	hsa-miR-4477a	PAR-CLIP	26701625
MIRT506945	hsa-miR-4477a	PAR-CLIP	26701625
MIRT506945	hsa-miR-4477a	PAR-CLIP	26701625
MIRT506945	hsa-miR-4477a	PAR-CLIP	26701625
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT506948	hsa-miR-132-3p	PAR-CLIP	27292025
MIRT506947	hsa-miR-212-3p	PAR-CLIP	27292025
MIRT506945	hsa-miR-4477a	PAR-CLIP	27292025
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	27292025
MIRT657278	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT657277	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT657276	hsa-miR-548ax	HITS-CLIP	23824327
MIRT657274	hsa-miR-5585-5p	HITS-CLIP	23824327
MIRT657275	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT657273	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT657272	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT657271	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT506948	hsa-miR-132-3p	PAR-CLIP	22012620
MIRT506947	hsa-miR-212-3p	PAR-CLIP	22012620
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	22012620
MIRT506945	hsa-miR-4477a	PAR-CLIP	22012620
MIRT506948	hsa-miR-132-3p	PAR-CLIP	23446348
MIRT506947	hsa-miR-212-3p	PAR-CLIP	23446348
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT506945	hsa-miR-4477a	PAR-CLIP	23446348
MIRT506948	hsa-miR-132-3p	PAR-CLIP	23446348
MIRT506947	hsa-miR-212-3p	PAR-CLIP	23446348
MIRT506946	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT506945	hsa-miR-4477a	PAR-CLIP	23446348
MIRT1054938	hsa-miR-1	CLIP-seq
MIRT1054939	hsa-miR-146a	CLIP-seq
MIRT1054940	hsa-miR-146b-5p	CLIP-seq
MIRT1054941	hsa-miR-1827	CLIP-seq
MIRT1054942	hsa-miR-206	CLIP-seq
MIRT1054943	hsa-miR-216a	CLIP-seq
MIRT1054944	hsa-miR-216b	CLIP-seq
MIRT1054945	hsa-miR-3173-3p	CLIP-seq
MIRT1054946	hsa-miR-320e	CLIP-seq
MIRT1054947	hsa-miR-3612	CLIP-seq
MIRT1054948	hsa-miR-3673	CLIP-seq
MIRT1054949	hsa-miR-3686	CLIP-seq
MIRT1054950	hsa-miR-4434	CLIP-seq
MIRT1054951	hsa-miR-4516	CLIP-seq
MIRT1054952	hsa-miR-4531	CLIP-seq
MIRT1054953	hsa-miR-4652-3p	CLIP-seq
MIRT1054954	hsa-miR-4695-5p	CLIP-seq
MIRT1054955	hsa-miR-577	CLIP-seq
MIRT1054956	hsa-miR-613	CLIP-seq
MIRT1054957	hsa-miR-650	CLIP-seq
MIRT1054938	hsa-miR-1	CLIP-seq
MIRT1054942	hsa-miR-206	CLIP-seq
MIRT1054946	hsa-miR-320e	CLIP-seq
MIRT1054948	hsa-miR-3673	CLIP-seq
MIRT1054956	hsa-miR-613	CLIP-seq
MIRT1054938	hsa-miR-1	CLIP-seq
MIRT1054941	hsa-miR-1827	CLIP-seq
MIRT1054942	hsa-miR-206	CLIP-seq
MIRT1054945	hsa-miR-3173-3p	CLIP-seq
MIRT1054946	hsa-miR-320e	CLIP-seq
MIRT1054947	hsa-miR-3612	CLIP-seq
MIRT1054948	hsa-miR-3673	CLIP-seq
MIRT2244830	hsa-miR-4514	CLIP-seq
MIRT2244831	hsa-miR-4692	CLIP-seq
MIRT1054954	hsa-miR-4695-5p	CLIP-seq
MIRT1054956	hsa-miR-613	CLIP-seq
MIRT1054957	hsa-miR-650	CLIP-seq
MIRT2244832	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001658	Process	Branching involved in ureteric bud morphogenesis	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9988767
GO:0006024	Process	Glycosaminoglycan biosynthetic process	IDA	9988768
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IBA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IDA	9988768
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase activity	TAS	9988767
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	TAS	9988767, 9988768
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA

MIM	HGNC	e!Ensembl
604058	5198	ENSG00000125430

Q9Y662

Protein name

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (h3-OST-3B)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:9988768). Catal

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	137 → 384	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney. {ECO:0000269|PubMed:9988767}.

Sequence

MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWLYMFLYSCAGSCAAAPG
LLLLGSGSRAAHDPPALATAPDGTPPRLPFRAPPATPLASGKEMAEGAASPEEQSPEVPD
SPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKG
LAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQ
TLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERL
ISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEI
DREVVRRLREFYRPFNLKFYQMTGHDFGWD

Sequence length

390

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - heparan sulfate / heparin		HS-GAG biosynthesis

HS3ST3B1 (heparan sulfate-glucosamine 3-sulfotransferase 3B1)