GOLGA5 (golgin A5)

Gene

• Entrez ID: 9950
• Gene name: Golgin A5
• Gene symbol: GOLGA5
• Synonyms (NCBI Gene): GOLIM5, RFG5, ret-II
• Chromosome: 14
• Chromosome location: 14q32.12
• Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000847	hsa-miR-15a-5p	Microarray	18362358
MIRT000846	hsa-miR-16-5p	Microarray	18362358
MIRT021619	hsa-miR-142-3p	Microarray	17612493
MIRT036073	hsa-miR-1296-5p	CLASH	23622248
MIRT697044	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT697043	hsa-miR-5683	HITS-CLIP	23313552
MIRT697042	hsa-miR-4257	HITS-CLIP	23313552
MIRT697041	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT697040	hsa-miR-4527	HITS-CLIP	23313552
MIRT697039	hsa-miR-6503-5p	HITS-CLIP	23313552
MIRT697038	hsa-miR-6753-3p	HITS-CLIP	23313552
MIRT697037	hsa-miR-7107-3p	HITS-CLIP	23313552
MIRT697036	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT697035	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT697034	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT697033	hsa-miR-6809-3p	HITS-CLIP	23313552
MIRT697032	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT697044	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT697043	hsa-miR-5683	HITS-CLIP	23313552
MIRT697042	hsa-miR-4257	HITS-CLIP	23313552
MIRT697041	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT697040	hsa-miR-4527	HITS-CLIP	23313552
MIRT697039	hsa-miR-6503-5p	HITS-CLIP	23313552
MIRT697038	hsa-miR-6753-3p	HITS-CLIP	23313552
MIRT697037	hsa-miR-7107-3p	HITS-CLIP	23313552
MIRT697036	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT697035	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT697034	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT697033	hsa-miR-6809-3p	HITS-CLIP	23313552
MIRT697032	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT1026290	hsa-miR-196a	CLIP-seq
MIRT1026291	hsa-miR-196b	CLIP-seq
MIRT1026292	hsa-miR-2053	CLIP-seq
MIRT1026293	hsa-miR-3160-3p	CLIP-seq
MIRT1026294	hsa-miR-331-5p	CLIP-seq
MIRT1026295	hsa-miR-338-5p	CLIP-seq
MIRT1026296	hsa-miR-3927	CLIP-seq
MIRT1026297	hsa-miR-4330	CLIP-seq
MIRT1026298	hsa-miR-4422	CLIP-seq
MIRT1026299	hsa-miR-4650-3p	CLIP-seq
MIRT1026300	hsa-miR-4663	CLIP-seq
MIRT1026301	hsa-miR-4666-3p	CLIP-seq
MIRT1026302	hsa-miR-4699-5p	CLIP-seq
MIRT1026303	hsa-miR-577	CLIP-seq
MIRT1026304	hsa-miR-668	CLIP-seq
MIRT1026305	hsa-miR-7	CLIP-seq
MIRT2004422	hsa-miR-1208	CLIP-seq
MIRT2004423	hsa-miR-2117	CLIP-seq
MIRT2004424	hsa-miR-4273	CLIP-seq
MIRT1026297	hsa-miR-4330	CLIP-seq
MIRT2004425	hsa-miR-4423-3p	CLIP-seq
MIRT2004426	hsa-miR-4803	CLIP-seq
MIRT2004427	hsa-miR-548ae	CLIP-seq
MIRT2004428	hsa-miR-548aj	CLIP-seq
MIRT2004429	hsa-miR-548am	CLIP-seq
MIRT2004430	hsa-miR-548x	CLIP-seq
MIRT2004431	hsa-miR-581	CLIP-seq
MIRT2004432	hsa-miR-590-3p	CLIP-seq
MIRT2004433	hsa-miR-656	CLIP-seq
MIRT1026304	hsa-miR-668	CLIP-seq
MIRT2004423	hsa-miR-2117	CLIP-seq
MIRT2237004	hsa-miR-34b	CLIP-seq
MIRT2004424	hsa-miR-4273	CLIP-seq
MIRT1026297	hsa-miR-4330	CLIP-seq
MIRT2004425	hsa-miR-4423-3p	CLIP-seq
MIRT2237005	hsa-miR-4705	CLIP-seq
MIRT2237006	hsa-miR-4772-3p	CLIP-seq
MIRT2004426	hsa-miR-4803	CLIP-seq
MIRT2004432	hsa-miR-590-3p	CLIP-seq
MIRT1026293	hsa-miR-3160-3p	CLIP-seq
MIRT1026297	hsa-miR-4330	CLIP-seq
MIRT1026298	hsa-miR-4422	CLIP-seq
MIRT1026300	hsa-miR-4663	CLIP-seq
MIRT1026303	hsa-miR-577	CLIP-seq
MIRT2540938	hsa-miR-3973	CLIP-seq
MIRT2540939	hsa-miR-520d-5p	CLIP-seq
MIRT2540940	hsa-miR-524-5p	CLIP-seq
MIRT2540941	hsa-miR-548a-5p	CLIP-seq
MIRT2540942	hsa-miR-548ab	CLIP-seq
MIRT2540943	hsa-miR-548ak	CLIP-seq
MIRT2540944	hsa-miR-548b-5p	CLIP-seq
MIRT2540945	hsa-miR-548c-5p	CLIP-seq
MIRT2540946	hsa-miR-548d-5p	CLIP-seq
MIRT2540947	hsa-miR-548h	CLIP-seq
MIRT2540948	hsa-miR-548i	CLIP-seq
MIRT2540949	hsa-miR-548j	CLIP-seq
MIRT2540950	hsa-miR-548w	CLIP-seq
MIRT2540951	hsa-miR-548y	CLIP-seq
MIRT2540952	hsa-miR-559	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0000301	Process	Retrograde transport, vesicle recycling within Golgi	IBA
GO:0005794	Component	Golgi apparatus	IDA	9915833
GO:0005794	Component	Golgi apparatus	IEA
GO:0005801	Component	Cis-Golgi network	IDA	12538640
GO:0007030	Process	Golgi organization	IBA
GO:0007030	Process	Golgi organization	IEA
GO:0007030	Process	Golgi organization	IMP	12538640
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	9915833
GO:0016020	Component	Membrane	IEA
GO:0030133	Component	Transport vesicle	TAS
GO:0031267	Function	Small GTPase binding	IDA	12538640
GO:0031985	Component	Golgi cisterna	IBA
GO:0031985	Component	Golgi cisterna	IDA	12538640
GO:0042803	Function	Protein homodimerization activity	IPI	9915833
GO:0048193	Process	Golgi vesicle transport	IMP	12538640

Other IDs

• MIM: 606918
• HGNC: 4428
• e!Ensembl: ENSG00000066455

Protein

• UniProt ID: Q8TBA6
• Protein name: Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein)
• Protein function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09787	Golgin_A5	420 → 725	Golgin subfamily A member 5	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa. {ECO:0000269|PubMed:9915833}.
• Sequence:

  MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKS
  TYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDD
  ELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQT
  HEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQS
  LNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQ
  LAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADAT
  LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLN
  LESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQRE
  EIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ
  EFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQ
  KQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFN
  DTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYT
  PEMHHDQPYGK

• Sequence length: 731

Pathways

Reactome:

Intra-Golgi traffic